6XLV
Crystal structure of leukemia-associated N196K mutant of U2AF65 bound to AdML splice site
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Splicing factor U2AF 65 kDa subunit | polymer | 204 | 22252.4 | 1 | UniProt (P26368) Pfam (PF00076) In PDB | Homo sapiens (Human) | U2 auxiliary factor 65 kDa subunit,hU2AF65,U2 snRNP auxiliary factor large subunit |
2 | B | DNA/RNA (5'-R(P*UP*UP*(UD)P*UP*U)-D(P*(BRU))-R(P*CP*C)-3') | polymer | 8 | 2449.3 | 1 | synthetic construct | ||
3 | water | water | 18.0 | 275 | Chemie (HOH) |
Sequence modifications
A: 141 - 341 (UniProt: P26368)
PDB | External Database | Details |
---|---|---|
Gly 138 | - | expression tag |
Pro 139 | - | expression tag |
Leu 140 | - | expression tag |
Lys 196 | Asn 196 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 24701.7 | |
All* | Total formula weight | 24701.7 |