6SJ7

Structure of the human DDB1-DDA1-DCAF15 E3 ubiquitin ligase bound to RBM39 and Indisulam

Summary for 6SJ7

Entry DOI	10.2210/pdb6sj7/pdb
EMDB information	10213
Descriptor	DDB1- and CUL4-associated factor 15, DNA damage-binding protein 1, RNA binding protein 39, ... (5 entities in total)
Functional Keywords	ddb1, oncoprotein
Biological source	Homo sapiens (Human) More
Total number of polymer chains	4
Total formula weight	214856.12
Authors	Srinivas, H. (deposition date: 2019-08-12, release date: 2019-12-18, Last modification date: 2019-12-25)
Primary citation	Bussiere, D.E.,Xie, L.,Srinivas, H.,Shu, W.,Burke, A.,Be, C.,Zhao, J.,Godbole, A.,King, D.,Karki, R.G.,Hornak, V.,Xu, F.,Cobb, J.,Carte, N.,Frank, A.O.,Frommlet, A.,Graff, P.,Knapp, M.,Fazal, A.,Okram, B.,Jiang, S.,Michellys, P.Y.,Beckwith, R.,Voshol, H.,Wiesmann, C.,Solomon, J.M.,Paulk, J. Structural basis of indisulam-mediated RBM39 recruitment to DCAF15 E3 ligase complex. Nat.Chem.Biol., 16:15-23, 2020 Cited by PubMed: 31819272 DOI: 10.1038/s41589-019-0411-6 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.54 Å)

Structure validation