PDB: 657 件ウェブページステータス検索Chemie searchBIRD

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7YSJ	GluK1-1a in nanodisc captured in SYM2081 bound desensitized state 分子名称: Glutamate receptor 著者 Dhingra, S, Kumar, J. 登録日 2022-08-12 公開日 2023-08-16 最終更新日 2024-03-13 実験手法 ELECTRON MICROSCOPY (5.2 Å) 主引用文献 Functional Implications of the Exon 9 Splice Insert in GluK1 Kainate Receptors Elife, 2023
5MFW	Crystal structure of the GluK1 ligand-binding domain in complex with kainate and BPAM-121 at 2.10 A resolution 分子名称: 3-(CARBOXYMETHYL)-4-ISOPROPENYLPROLINE, 7-chloro-4-(2-fluoroethyl)-2,3-dihydro-1,2,4-benzothiadiazine 1,1-dioxide, ACETATE ION, ... 著者 Larsen, A.P, Frydenvang, K, Kastrup, J.S. 登録日 2016-11-18 公開日 2017-04-12 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Identification and Structure-Function Study of Positive Allosteric Modulators of Kainate Receptors. Mol. Pharmacol., 91, 2017
5MFQ	Crystal structure of the GluK1 ligand-binding domain in complex with kainate and BPAM-344 at 1.90 A resolution 分子名称: 3-(CARBOXYMETHYL)-4-ISOPROPENYLPROLINE, 4-cyclopropyl-7-fluoro-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide, CHLORIDE ION, ... 著者 Larsen, A.P, Frydenvang, K, Kastrup, J.S. 登録日 2016-11-18 公開日 2017-04-12 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Identification and Structure-Function Study of Positive Allosteric Modulators of Kainate Receptors. Mol. Pharmacol., 91, 2017
5M2V	Structure of GluK1 ligand-binding domain (S1S2) in complex with (2S,4R)-4-(2-carboxyphenoxy)pyrrolidine-2-carboxylic acid at 3.18 A resolution 分子名称: (2~{S},4~{R})-4-(2-carboxyphenoxy)pyrrolidine-2-carboxylic acid, CHLORIDE ION, Glutamate receptor ionotropic, ... 著者 Frydenvang, K, Kastrup, J.S, Kristensen, C.M. 登録日 2016-10-13 公開日 2017-01-11 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (3.18 Å) 主引用文献 Design and Synthesis of a Series of l-trans-4-Substituted Prolines as Selective Antagonists for the Ionotropic Glutamate Receptors Including Functional and X-ray Crystallographic Studies of New Subtype Selective Kainic Acid Receptor Subtype 1 (GluK1) Antagonist (2S,4R)-4-(2-Carboxyphenoxy)pyrrolidine-2-carboxylic Acid. J. Med. Chem., 60, 2017
7Z2R	Differences between the GluD1 and GluD2 receptors revealed by GluD1 X-ray crystallography, binding studies and molecular dynamics 分子名称: Glutamate receptor ionotropic, delta-1, SULFATE ION 著者 Masternak, M, Laulumaa, S, Kastrup, J.S. 登録日 2022-02-28 公開日 2023-01-11 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.574 Å) 主引用文献 Differences between the GluD1 and GluD2 receptors revealed by GluD1 X-ray crystallography, binding studies and molecular dynamics. Febs J., 290, 2023
8C1S	Transmembrane domain of resting state homomeric GluA2 F231A mutant AMPA receptor in complex with TARP gamma 2 分子名称: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, Glutamate receptor 2, ... 著者 Zhang, D, Ivica, J, Krieger, J.M, Ho, H, Yamashita, K, Cais, O, Greger, I. 登録日 2022-12-21 公開日 2023-08-30 最終更新日 2023-10-11 実験手法 ELECTRON MICROSCOPY (3 Å) 主引用文献 Structural mobility tunes signalling of the GluA1 AMPA glutamate receptor. Nature, 621, 2023
8C1R	Resting state homomeric GluA2 F231A mutant AMPA receptor in complex with TARP gamma-2 分子名称: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, Glutamate receptor 2, ... 著者 Zhang, D, Ivica, J, Krieger, J.M, Ho, H, Yamashita, K, Cais, O, Greger, I. 登録日 2022-12-21 公開日 2023-08-30 最終更新日 2023-10-11 実験手法 ELECTRON MICROSCOPY (3.2 Å) 主引用文献 Structural mobility tunes signalling of the GluA1 AMPA glutamate receptor. Nature, 621, 2023
8C1Q	Resting state homomeric GluA1 AMPA receptor in complex with TARP gamma 3 分子名称: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, Glutamate receptor 1 flip isoform, ... 著者 Zhang, D, Ivica, J, Krieger, J.M, Ho, H, Yamashita, K, Cais, O, Greger, I. 登録日 2022-12-21 公開日 2023-08-30 最終更新日 2023-10-11 実験手法 ELECTRON MICROSCOPY (2.82 Å) 主引用文献 Structural mobility tunes signalling of the GluA1 AMPA glutamate receptor. Nature, 621, 2023
8C2H	Transmembrane domain of active state homomeric GluA1 AMPA receptor in tandem with TARP gamma 3 分子名称: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, Glutamate receptor 1 flip isoform, ... 著者 Zhang, D, Ivica, J, Krieger, J.M, Ho, H, Yamashita, K, Cais, O, Greger, I. 登録日 2022-12-22 公開日 2023-08-30 最終更新日 2023-10-11 実験手法 ELECTRON MICROSCOPY (2.64 Å) 主引用文献 Structural mobility tunes signalling of the GluA1 AMPA glutamate receptor. Nature, 621, 2023
8C1P	Active state homomeric GluA1 AMPA receptor in complex with TARP gamma 3 分子名称: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, CYCLOTHIAZIDE, ... 著者 Zhang, D, Ivica, J, Krieger, J.M, Ho, H, Yamashita, K, Cais, O, Greger, I. 登録日 2022-12-21 公開日 2023-08-30 最終更新日 2023-10-11 実験手法 ELECTRON MICROSCOPY (2.9 Å) 主引用文献 Structural mobility tunes signalling of the GluA1 AMPA glutamate receptor. Nature, 621, 2023
2UXA	Crystal structure of the GluR2-flip ligand binding domain, r/g unedited. 分子名称: GLUTAMATE RECEPTOR SUBUNIT GLUR2-FLIP, GLUTAMIC ACID, ZINC ION 著者 Greger, I.H, Akamine, P, Khatri, L, Ziff, E.B. 登録日 2007-03-27 公開日 2007-04-10 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2.38 Å) 主引用文献 Developmentally Regulated, Combinatorial RNA Processing Modulates Ampa Receptor Biogenesis. Neuron, 51, 2006
8C2I	Transmembrane domain of resting state homomeric GluA1 AMPA receptor in complex with TARP gamma 3 分子名称: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, Glutamate receptor 1 flip isoform, ... 著者 Zhang, D, Ivica, J, Krieger, J.M, Ho, H, Yamashita, K, Cais, O, Greger, I. 登録日 2022-12-22 公開日 2023-08-30 最終更新日 2023-10-11 実験手法 ELECTRON MICROSCOPY (2.7 Å) 主引用文献 Structural mobility tunes signalling of the GluA1 AMPA glutamate receptor. Nature, 621, 2023
5MFV	Crystal structure of the GluK1 ligand-binding domain in complex with kainate and BPAM-521 at 2.18 A resolution 分子名称: 3-(CARBOXYMETHYL)-4-ISOPROPENYLPROLINE, 4-Cyclopropyl-3,4-dihydro-7-hydroxy-2H-1,2,4-benzothiadiazine 1,1-dioxide, ACETATE ION, ... 著者 Larsen, A.P, Frydenvang, K, Kastrup, J.S. 登録日 2016-11-18 公開日 2017-04-12 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.181 Å) 主引用文献 Identification and Structure-Function Study of Positive Allosteric Modulators of Kainate Receptors. Mol. Pharmacol., 91, 2017
2V3T	Structure of the ligand-binding core of the ionotropic glutamate receptor-like GluRdelta2 in the apo form 分子名称: CALCIUM ION, GLUTAMATE RECEPTOR DELTA-2 SUBUNIT SYNONYM GLURDELTA2, GLUR DELTA-2 著者 Naur, P, Vestergaard, B, Gajhede, M, Kastrup, J.S. 登録日 2007-06-22 公開日 2007-08-07 最終更新日 2019-07-24 実験手法 X-RAY DIFFRACTION (2.75 Å) 主引用文献 Ionotropic Glutamate-Like Receptor {Delta}2 Binds D-Serine and Glycine. Proc.Natl.Acad.Sci.USA, 104, 2007
5NF6	Structure of GluK3 ligand-binding domain (S1S2) in complex with CIP-AS at 2.55 A resolution 分子名称: (3~{a}~{S},4~{S},6~{a}~{R})-4,5,6,6~{a}-tetrahydro-3~{a}~{H}-pyrrolo[3,4-d][1,2]oxazole-3,4-dicarboxylic acid, ACETATE ION, CHLORIDE ION, ... 著者 Frydenvang, K, Venskutonyte, R, Thorsen, T.S, Kastrup, J.S. 登録日 2017-03-13 公開日 2017-07-26 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.55 Å) 主引用文献 Structure and Affinity of Two Bicyclic Glutamate Analogues at AMPA and Kainate Receptors. ACS Chem Neurosci, 8, 2017
7YFG	Structure of the Rat GluN1-GluN2C NMDA receptor in complex with glycine and glutamate (major class in asymmetry) 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, GLUTAMIC ACID, ... 著者 Zhang, M, Zhang, J, Guo, F, Li, Y, Zhu, S. 登録日 2022-07-08 公開日 2023-03-29 最終更新日 2023-05-31 実験手法 ELECTRON MICROSCOPY (3.6 Å) 主引用文献 Distinct structure and gating mechanism in diverse NMDA receptors with GluN2C and GluN2D subunits. Nat.Struct.Mol.Biol., 30, 2023
7YFM	Structure of GluN1b-GluN2D NMDA receptor in complex with agonists glycine and glutamate. 分子名称: Glutamate receptor ionotropic, NMDA 2D, Isoform 6 of Glutamate receptor ionotropic, ... 著者 Zhang, J.L, Zhu, S.J, Zhang, M. 登録日 2022-07-08 公開日 2023-03-29 最終更新日 2023-08-02 実験手法 ELECTRON MICROSCOPY (5.1 Å) 主引用文献 Distinct structure and gating mechanism in diverse NMDA receptors with GluN2C and GluN2D subunits. Nat.Struct.Mol.Biol., 30, 2023
2V3U	Structure of the ligand-binding core of the ionotropic glutamate receptor-like GluRdelta2 in complex with D-serine 分子名称: CHLORIDE ION, D-SERINE, GLUTAMATE RECEPTOR DELTA-2 SUBUNIT, ... 著者 Naur, P, Vestergaard, B, Gajhede, M, Kastrup, J.S. 登録日 2007-06-22 公開日 2007-08-07 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (1.74 Å) 主引用文献 Ionotropic Glutamate-Like Receptor {Delta}2 Binds D-Serine and Glycine. Proc.Natl.Acad.Sci.USA, 104, 2007
2WKY	Crystal structure of the ligand-binding core of GluR5 in complex with the agonist 4-AHCP 分子名称: 3-(3-HYDROXY-7,8-DIHYDRO-6H-CYCLOHEPTA[D]ISOXAZOL-4-YL)-L-ALANINE, CHLORIDE ION, GLUTAMATE RECEPTOR, ... 著者 Naur, P, Gajhede, M, Kastrup, J.S. 登録日 2009-06-18 公開日 2009-07-21 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 The Glutamate Receptor Glur5 Agonist (S)-2-Amino-3-(3-Hydroxy-7,8-Dihydro-6H-Cyclohepta[D]Isoxazol-4-Yl)Propionic Acid and the 8-Methyl Analogue: Synthesis, Molecular Pharmacology, and Biostructural Characterization J.Med.Chem., 52, 2009
6DM0	Open state GluA2 in complex with STZ and blocked by IEM-1460, after micelle signal subtraction 分子名称: CYCLOTHIAZIDE, GLUTAMIC ACID, Glutamate receptor 2,Voltage-dependent calcium channel gamma-2 subunit, ... 著者 Twomey, E.C, Yelshanskaya, M.V, Vassilevski, A.A, Sobolevsky, A.I. 登録日 2018-06-04 公開日 2018-08-22 最終更新日 2019-12-18 実験手法 ELECTRON MICROSCOPY (4.4 Å) 主引用文献 Mechanisms of Channel Block in Calcium-Permeable AMPA Receptors. Neuron, 99, 2018
6HCB	STRUCTURE OF GLUA2 LIGAND-BINDING DOMAIN (S1S2J-N775S) IN COMPLEX WITH GLUTAMATE AND TDPAM01 AT 1.9 A RESOLUTION. 分子名称: 6,6'-(Ethane-1,2-diyl)bis(4-methyl-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide), CHLORIDE ION, DI(HYDROXYETHYL)ETHER, ... 著者 Laulumaa, S, Masternak, M, Frydenvang, K, Kastrup, J.S. 登録日 2018-08-14 公開日 2019-04-03 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Crystal Structures of Potent Dimeric Positive Allosteric Modulators at the Ligand-Binding Domain of the GluA2 Receptor. Acs Med.Chem.Lett., 10, 2019
6DLZ	Open state GluA2 in complex with STZ after micelle signal subtraction 分子名称: CYCLOTHIAZIDE, GLUTAMIC ACID, Glutamate receptor 2,Voltage-dependent calcium channel gamma-2 subunit 著者 Twomey, E.C, Yelshanskaya, M.V, Vassilevski, A.A, Sobolevsky, A.I. 登録日 2018-06-04 公開日 2018-08-22 最終更新日 2019-12-18 実験手法 ELECTRON MICROSCOPY (3.9 Å) 主引用文献 Mechanisms of Channel Block in Calcium-Permeable AMPA Receptors. Neuron, 99, 2018
6IRA	Structure of the human GluN1/GluN2A NMDA receptor in the glutamate/glycine-bound state at pH 7.8 分子名称: Glutamate receptor ionotropic, NMDA 1, NMDA 2A 著者 Zhang, J, Chang, S, Zhang, X, Zhu, S. 登録日 2018-11-12 公開日 2019-01-16 最終更新日 2019-06-05 実験手法 ELECTRON MICROSCOPY (4.5 Å) 主引用文献 Structural Basis of the Proton Sensitivity of Human GluN1-GluN2A NMDA Receptors Cell Rep, 25, 2018
6IRF	Structure of the human GluN1/GluN2A NMDA receptor in the glutamate/glycine-bound state at pH 6.3, Class I 分子名称: Glutamate receptor ionotropic, NMDA 1, NMDA 2A 著者 Zhang, J, Chang, S, Zhang, X, Zhu, S. 登録日 2018-11-12 公開日 2019-01-16 最終更新日 2019-06-05 実験手法 ELECTRON MICROSCOPY (5.1 Å) 主引用文献 Structural Basis of the Proton Sensitivity of Human GluN1-GluN2A NMDA Receptors Cell Rep, 25, 2018
6IRH	Structure of the human GluN1/GluN2A NMDA receptor in the glutamate/glycine-bound state at pH 6.3, Class III 分子名称: Glutamate receptor ionotropic, NMDA 1, NMDA 2A 著者 Zhang, J, Chang, S, Zhang, X, Zhu, S. 登録日 2018-11-12 公開日 2019-01-16 最終更新日 2019-06-05 実験手法 ELECTRON MICROSCOPY (7.8 Å) 主引用文献 Structural Basis of the Proton Sensitivity of Human GluN1-GluN2A NMDA Receptors Cell Rep, 25, 2018

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