5MFW
Crystal structure of the GluK1 ligand-binding domain in complex with kainate and BPAM-121 at 2.10 A resolution
Summary for 5MFW
Entry DOI | 10.2210/pdb5mfw/pdb |
Descriptor | Glutamate receptor ionotropic, kainate 1,Glutamate receptor ionotropic, kainate 1, 7-chloro-4-(2-fluoroethyl)-2,3-dihydro-1,2,4-benzothiadiazine 1,1-dioxide, CHLORIDE ION, ... (8 entities in total) |
Functional Keywords | ionotropic glutamate receptor, gluk1 ligand-binding domain, membrane protein, positive allosteric modulator |
Biological source | Rattus norvegicus (Rat) More |
Cellular location | Cell membrane; Multi-pass membrane protein: P22756 |
Total number of polymer chains | 2 |
Total formula weight | 59931.77 |
Authors | Larsen, A.P.,Frydenvang, K.,Kastrup, J.S. (deposition date: 2016-11-18, release date: 2017-04-12, Last modification date: 2024-01-17) |
Primary citation | Larsen, A.P.,Fievre, S.,Frydenvang, K.,Francotte, P.,Pirotte, B.,Kastrup, J.S.,Mulle, C. Identification and Structure-Function Study of Positive Allosteric Modulators of Kainate Receptors. Mol. Pharmacol., 91:576-585, 2017 Cited by PubMed: 28360094DOI: 10.1124/mol.116.107599 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
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