2WKY

Crystal structure of the ligand-binding core of GluR5 in complex with the agonist 4-AHCP

Summary for 2WKY

• Entry DOI: 10.2210/pdb2wky/pdb
• Related: 1TXF 1YCJ 2F34 2F35 2F36
• Descriptor: GLUTAMATE RECEPTOR, IONOTROPIC KAINATE 1, CHLORIDE ION, 3-(3-HYDROXY-7,8-DIHYDRO-6H-CYCLOHEPTA[D]ISOXAZOL-4-YL)-L-ALANINE, ... (4 entities in total)
• Functional Keywords: membrane protein, synapse, membrane, receptor, transport, ion channel, rna editing, glycoprotein, cell junction, ionotropic glutamate receptor, alternative splicing, postsynaptic cell membrane, ionic channel, cell membrane, ion transport, transmembrane, phosphoprotein, ligand-binding core
• Biological source: RATTUS NORVEGICUS (RAT)
• Cellular location: Cell membrane; Multi-pass membrane protein: P22756
• Total number of polymer chains: 2
• Total formula weight: 59022.52

Authors

Naur, P.,Gajhede, M.,Kastrup, J.S. (deposition date: 2009-06-18, release date: 2009-07-21, Last modification date: 2023-12-13)

• Primary citation: Clausen, R.P.,Naur, P.,Kristensen, A.S.,Greenwood, J.R.,Strange, M.,Brauner-Osborne, H.,Jensen, A.A.,Nielsen, A.S.,Geneser, U.,Ringgaard, L.M.,Nielsen, B.,Pickering, D.S.,Brehm, L.,Gajhede, M.,Krogsgaard-Larsen, P.,Kastrup, J.S.; The Glutamate Receptor Glur5 Agonist (S)-2-Amino-3-(3-Hydroxy-7,8-Dihydro-6H-Cyclohepta[D]Isoxazol-4-Yl)Propionic Acid and the 8-Methyl Analogue: Synthesis, Molecular Pharmacology, and Biostructural Characterization; J.Med.Chem., 52:4911-, 2009; PubMed: 19588945; DOI: 10.1021/JM900565C

Experimental method

X-RAY DIFFRACTION (2.2 Å)