1YCJ

Crystal structure of the kainate receptor GluR5 ligand-binding core in complex with (S)-glutamate

Summary for 1YCJ

• Entry DOI: 10.2210/pdb1ycj/pdb
• Related: 1FTJ
• Descriptor: Ionotropic glutamate receptor 5, SULFATE ION, GLUTAMIC ACID, ... (4 entities in total)
• Functional Keywords: ionotropic glutamate receptor, kainate receptor, glur5 ligand-binding core, membrane protein
• Biological source: Rattus norvegicus (Norway rat); More
• Total number of polymer chains: 2
• Total formula weight: 59183.61

Authors

Naur, P.,Vestergaard, B.,Skov, L.K.,Egebjerg, J.,Gajhede, M.,Kastrup, J.S. (deposition date: 2004-12-22, release date: 2005-02-01, Last modification date: 2024-11-13)

Primary citation

Naur, P.,Vestergaard, B.,Skov, L.K.,Egebjerg, J.,Gajhede, M.,Kastrup, J.S.
Crystal structure of the kainate receptor GluR5 ligand-binding core in complex with (S)-glutamate
Febs Lett., 579:1154-1160, 2005

PubMed Abstract: The X-ray structure of the ligand-binding core of the kainate receptor GluR5 (GluR5-S1S2) in complex with (S)-glutamate was determined to 1.95 A resolution. The overall GluR5-S1S2 structure comprises two domains and is similar to the related AMPA receptor GluR2-S1S2J. (S)-glutamate binds as in GluR2-S1S2J. Distinct features are observed for Ser741, which stabilizes a highly coordinated network of water molecules and forms an interdomain bridge. The GluR5 complex exhibits a high degree of domain closure (26 degrees) relative to apo GluR2-S1S2J. In addition, GluR5-S1S2 forms a novel dimer interface with a different arrangement of the two protomers compared to GluR2-S1S2J.

PubMed: 15710405
DOI: 10.1016/j.febslet.2005.01.012

Experimental method

X-RAY DIFFRACTION (1.95 Å)