5MFV

Crystal structure of the GluK1 ligand-binding domain in complex with kainate and BPAM-521 at 2.18 A resolution

Summary for 5MFV

• Entry DOI: 10.2210/pdb5mfv/pdb
• Descriptor: Glutamate receptor ionotropic, kainate 1,Glutamate receptor ionotropic, kainate 1, 4-Cyclopropyl-3,4-dihydro-7-hydroxy-2H-1,2,4-benzothiadiazine 1,1-dioxide, 3-(CARBOXYMETHYL)-4-ISOPROPENYLPROLINE, ... (8 entities in total)
• Functional Keywords: ionotropic glutamate receptor, gluk1 ligand-binding domain, membrane protein, positive allosteric modulator
• Biological source: Rattus norvegicus (Rat); More
• Cellular location: Cell membrane; Multi-pass membrane protein: P22756
• Total number of polymer chains: 2
• Total formula weight: 59598.70

Authors

Larsen, A.P.,Frydenvang, K.,Kastrup, J.S. (deposition date: 2016-11-18, release date: 2017-04-12, Last modification date: 2024-01-17)

• Primary citation: Larsen, A.P.,Fievre, S.,Frydenvang, K.,Francotte, P.,Pirotte, B.,Kastrup, J.S.,Mulle, C.; Identification and Structure-Function Study of Positive Allosteric Modulators of Kainate Receptors.; Mol. Pharmacol., 91:576-585, 2017; PubMed: 28360094; DOI: 10.1124/mol.116.107599

Experimental method

X-RAY DIFFRACTION (2.181 Å)