PDB: 435 件ウェブページステータス検索Chemie searchBIRD

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6QQ7	Bovine insulin at ambient pressure 分子名称: Insulin 著者 Kurpiewska, K, Milaczewska, A, Lewinski, K. 登録日 2019-02-18 公開日 2019-02-27 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.65 Å) 主引用文献 Insulin conformational changes under high pressure in structural studies and molecular dynamics simulations J.Mol.Struct., 2020
6HN5	Leucine-zippered human insulin receptor ectodomain with single bound insulin - "upper" membrane-distal part 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Insulin, ... 著者 Weis, F, Menting, J.G, Margetts, M.B, Chan, S.J, Xu, Y, Tennagels, N, Wohlfart, P, Langer, T, Mueller, C.W, Dreyer, M.K, Lawrence, M.C. 登録日 2018-09-14 公開日 2018-11-21 最終更新日 2022-03-30 実験手法 ELECTRON MICROSCOPY (3.2 Å) 主引用文献 The signalling conformation of the insulin receptor ectodomain. Nat Commun, 9, 2018
6FF3	Crystal structure of Drosophila neural ectodermal development factor Imp-L1 with Human IGF-I 分子名称: Insulin-like growth factor I, Neural/ectodermal development factor IMP-L2 著者 Brzozowski, A.M, Kulahin, N, Kristensen, O, Schluckebier, G, Meyts, P.D, Viola, C.M. 登録日 2018-01-03 公開日 2018-09-26 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.57 Å) 主引用文献 Structures of insect Imp-L2 suggest an alternative strategy for regulating the bioavailability of insulin-like hormones. Nat Commun, 9, 2018
6FEY	Crystal structure of Drosophila neural ectodermal development factor Imp-L2 with Drosophila DILP5 insulin 分子名称: Neural/ectodermal development factor IMP-L2, Probable insulin-like peptide 5 著者 Brzozowski, A.M, Kulahin, N, Kristensen, O, Schluckebier, G, Meyts, P.D. 登録日 2018-01-03 公開日 2018-09-26 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (3.48 Å) 主引用文献 Structures of insect Imp-L2 suggest an alternative strategy for regulating the bioavailability of insulin-like hormones. Nat Commun, 9, 2018
6CK2	Insulin analog containing a YB26W mutation 分子名称: CHLORIDE ION, Insulin A chain, Insulin B chain, ... 著者 Rege, N.K, Yee, V.C, Weiss, M.A. 登録日 2018-02-27 公開日 2018-06-13 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.25 Å) 主引用文献 Structure-based stabilization of insulin as a therapeutic protein assembly via enhanced aromatic-aromatic interactions. J. Biol. Chem., 293, 2018
6CE9	Insulin Receptor ectodomain in complex with two insulin molecules 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... 著者 Scapin, G, Dandey, V.P, Zhang, Z, Strickland, C, Potter, C.S, Carragher, B. 登録日 2018-02-11 公開日 2018-03-14 最終更新日 2020-07-29 実験手法 ELECTRON MICROSCOPY (4.3 Å) 主引用文献 Structure of the insulin receptor-insulin complex by single-particle cryo-EM analysis. Nature, 556, 2018
6CEB	Insulin Receptor ectodomain in complex with two insulin molecules - C1 symmetry 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... 著者 Scapin, G, Dandey, V.P, Zhang, Z, Strickland, C, Potter, C.S, Carragher, B. 登録日 2018-02-11 公開日 2018-03-14 最終更新日 2020-07-29 実験手法 ELECTRON MICROSCOPY (4.7 Å) 主引用文献 Structure of the insulin receptor-insulin complex by single-particle cryo-EM analysis. Nature, 556, 2018
6CE7	Insulin Receptor ectodomain in complex with one insulin molecule 分子名称: Insulin A chain, Insulin B chain, Insulin receptor, ... 著者 Scapin, G, Dandey, V.P, Zhang, Z, Strickland, C, Potter, C.S, Carragher, B. 登録日 2018-02-11 公開日 2018-03-14 最終更新日 2019-12-18 実験手法 ELECTRON MICROSCOPY (7.4 Å) 主引用文献 Structure of the insulin receptor-insulin complex by single-particle cryo-EM analysis. Nature, 556, 2018
5U8Q	Structure of the ectodomain of the human Type 1 insulin-like growth factor receptor in complex with IGF-I 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, D-MALATE, ... 著者 Lawrence, M, Xu, Y. 登録日 2016-12-14 公開日 2018-02-28 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (3.2710402 Å) 主引用文献 How ligand binds to the type 1 insulin-like growth factor receptor. Nat Commun, 9, 2018
5USP	Insulin with proline analog Pip at position B28 in the T2 state 分子名称: Insulin Chain A, Insulin Chain B, SODIUM ION 著者 Lieblich, S.A, Fang, K.Y, Tirrell, D.A. 登録日 2017-02-13 公開日 2018-02-21 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (1.174 Å) 主引用文献 Insulin with proline analog Pip at position B28 in the T2 state To Be Published
5USS	Insulin with proline analog PiP at position B28 in the R6 state 分子名称: CHLORIDE ION, Insulin Chain A, Insulin Chain B, ... 著者 Lieblich, S.A, Fang, K.Y, Tirrell, D.A. 登録日 2017-02-13 公開日 2018-02-21 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2.061 Å) 主引用文献 Insulin with proline analog PiP at position B28 in the R6 state To Be Published
5UU2	Insulin with proline analog ThioP at position B28 in the T2 state 分子名称: Insulin Chain A, Insulin Chain B 著者 Lieblich, S.A, Fang, K.Y, Tirrell, D.A. 登録日 2017-02-15 公開日 2018-02-21 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.223 Å) 主引用文献 Insulin with proline analog ThioP at position B28 in the T2 state To Be Published
5UU4	Insulin with proline analog ThioP at position B28 in the R6 state 分子名称: CHLORIDE ION, Insulin A Chain, Insulin B Chain, ... 著者 Lieblich, S.A, Fang, K.Y, Tirrell, D.A. 登録日 2017-02-16 公開日 2018-02-21 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.973 Å) 主引用文献 Insulin with proline analog ThioP at position B28 in the R6 state To Be Published
5USV	Insulin with proline analog AzeP at position B28 in the T2 state 分子名称: Insulin Chain A, Insulin Chain B, SODIUM ION 著者 Lieblich, S.A, Fang, K.Y, Tirrell, D.A. 登録日 2017-02-14 公開日 2018-02-21 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (1.3 Å) 主引用文献 Insulin with proline analog AzeP at position B28 in the T2 state To Be Published
5URU	Insulin with proline analog DhP at position B28 in the R6 state 分子名称: CHLORIDE ION, Insulin Chain A, Insulin Chain B, ... 著者 Lieblich, S.A, Fang, K.Y, Tirrell, D.A. 登録日 2017-02-13 公開日 2018-02-21 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2.41 Å) 主引用文献 Insulin with proline analog DhP at position B28 in the R6 state To Be Published
5UQA	Insulin with proline analog FzP at position B28 in the R6 state 分子名称: ACETONE, CHLORIDE ION, GLYCEROL, ... 著者 Lieblich, S.A, Fang, K.Y, Tirrell, D.A. 登録日 2017-02-07 公開日 2018-02-21 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (1.31000245 Å) 主引用文献 Insulin with proline analog FzP at position B28 in the R6 state To Be Published
5UU3	Insulin with proline analog DfP at position B28 in the R6 state 分子名称: CHLORIDE ION, Insulin, chain A, ... 著者 Lieblich, S.A, Fang, K.Y, Tirrell, D.A. 登録日 2017-02-16 公開日 2018-02-21 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2.25 Å) 主引用文献 Insulin with proline analog DfP at position B28 in the R6 state To Be Published
5MWQ	Biosynthetic engineered A21K-B31K-B32R human insulin monomer structure in water/acetonitrile solution 分子名称: Insulin 著者 Bocian, W, Kozerski, L. 登録日 2017-01-19 公開日 2018-02-14 最終更新日 2023-06-14 実験手法 SOLUTION NMR 主引用文献 Lysine mis-incorporation at asparagine position during recombinant proteins production in E. coli To Be Published
5URT	Insulin with proline analog DhP at position B28 in the T2 state 分子名称: Insulin Chain A, Insulin Chain B, SODIUM ION 著者 Lieblich, S.A, Fang, K.Y, Tirrell, D.A. 登録日 2017-02-12 公開日 2018-02-14 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (1.18 Å) 主引用文献 Insulin with proline analog DhP at position B28 in the T2 state To Be Published
5UOZ	Insulin with proline analog FyP at position B28 in the T2 state 分子名称: Insulin Chain A, Insulin Chain B 著者 Lieblich, S.A, Fang, K.Y, Tirrell, D.A. 登録日 2017-02-01 公開日 2018-02-07 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (1.17463875 Å) 主引用文献 Insulin with proline analog FyP at position B28 in the T2 state To Be Published
6B70	Cryo-EM structure of human insulin degrading enzyme in complex with FAB H11-E heavy chain, FAB H11-E light chain and insulin 分子名称: FAB H11-E heavy chain, FAB H11-E light chain, Insulin, ... 著者 Liang, W.G, Zhang, Z, Bailey, L.J, Kossiakoff, A.A, Tan, Y.Z, Wei, H, Carragher, B, Potter, S.C, Tang, W.J. 登録日 2017-10-03 公開日 2017-12-27 最終更新日 2021-04-28 実験手法 ELECTRON MICROSCOPY (3.7 Å) 主引用文献 Ensemble cryoEM elucidates the mechanism of insulin capture and degradation by human insulin degrading enzyme. Elife, 7, 2018
6BFC	Cryo-EM structure of human insulin degrading enzyme in complex with insulin 分子名称: Insulin, Insulin-degrading enzyme 著者 Liang, W.G, Zhang, Z, Bailey, L.J, Kossiakoff, A.A, Tan, Y.Z, Wei, H, Carragher, B, Potter, S.C, Tang, W.J. 登録日 2017-10-26 公開日 2017-12-27 最終更新日 2021-04-28 実験手法 ELECTRON MICROSCOPY (3.7 Å) 主引用文献 Ensemble cryoEM elucidates the mechanism of insulin capture and degradation by human insulin degrading enzyme. Elife, 7, 2018
5T7R	A6-A11 trans-dicarba human insulin 分子名称: Insulin A chain, Insulin B chain 著者 Menting, J.G, Lawrence, M.C, Robinson, A.J, Forbes, B.E. 登録日 2016-09-05 公開日 2017-12-06 最終更新日 2019-06-19 実験手法 X-RAY DIFFRACTION (1.55 Å) 主引用文献 Insulin in motion: The A6-A11 disulfide bond allosterically modulates structural transitions required for insulin activity. Sci Rep, 7, 2017
6B3Q	Cryo-EM structure of human insulin degrading enzyme in complex with insulin 分子名称: Insulin, Insulin-degrading enzyme 著者 Liang, W.G, Zhang, Z, Bailey, L.J, Kossiakoff, A.A, Tan, Y.Z, Wei, H, Carragher, B, Potter, S.C, Tang, W.J. 登録日 2017-09-22 公開日 2017-11-22 最終更新日 2021-04-28 実験手法 ELECTRON MICROSCOPY (3.7 Å) 主引用文献 Ensemble cryoEM elucidates the mechanism of insulin capture and degradation by human insulin degrading enzyme. Elife, 7, 2018
5WBT	Solution Structure and Dynamics of an Ultra-Stable Single-Chain Insulin Analog STUDIES OF AN ENGINEERED MONOMER AND IMPLICATIONS FOR RECEPTOR BINDING 分子名称: Insulin 著者 Glidden, M.D, Yang, Y, Wickramasinghe, N.P, Weiss, M.A. 登録日 2017-06-29 公開日 2017-11-15 最終更新日 2023-06-14 実験手法 SOLUTION NMR 主引用文献 Solution structure of an ultra-stable single-chain insulin analog connects protein dynamics to a novel mechanism of receptor binding. J. Biol. Chem., 293, 2018

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