PDB: 435 件ウェブページステータス検索Chemie searchBIRD

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5BOQ	Human insulin with intra-chain chemical crosslink between modified B24 and B29 分子名称: Insulin, SULFATE ION 著者 Brzozowski, A.M, Turkenburg, J.P, Jiracek, J, Zakova, L. 登録日 2015-05-27 公開日 2016-02-03 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Rational steering of insulin binding specificity by intra-chain chemical crosslinking. Sci Rep, 6, 2016
3INC	Crystal structure of human insulin with Ni+2 complex 分子名称: Insulin A chain, Insulin B chain, NICKEL (II) ION 著者 Raghavendra, N, Pattabhi, V, Rajan, S.S. 登録日 2009-08-12 公開日 2010-08-18 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 Metal induced conformational changes in human insulin: Crystal structures of Sr+2, Ni+2 and Cu+2 complexes of human insulin To be Published
3INS	STRUCTURE OF INSULIN. RESULTS OF JOINT NEUTRON AND X-RAY REFINEMENT 分子名称: INSULIN (CHAIN A), INSULIN (CHAIN B), ZINC ION 著者 Wlodawer, A, Savage, H. 登録日 1988-10-14 公開日 1989-01-09 最終更新日 2017-11-29 実験手法 NEUTRON DIFFRACTION (1.5 Å), X-RAY DIFFRACTION 主引用文献 Structure of insulin: results of joint neutron and X-ray refinement. Acta Crystallogr.,Sect.B, 45, 1989
3IR0	Crystal Structure of Human Insulin complexed with Cu+2 metal ion 分子名称: COPPER (II) ION, Insulin A chain, Insulin B chain 著者 Raghavendra, N, Pattabhi, V, Rajan, S.S. 登録日 2009-08-21 公開日 2010-09-01 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Metal induced structural changes observed in Human insulin To be Published
3ILG	Crystal structure of humnan insulin Sr+2 complex 分子名称: Insulin A chain, Insulin B chain, STRONTIUM ION 著者 Raghavendra, N, Pattabhi, V, Rajan, S.S. 登録日 2009-08-07 公開日 2010-08-11 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Metal induced conformational changes in human insulin: Crystal structures of Sr+2, Ni+2 and Cu+2 complexes of human insulin To be Published
6S4J	Crystal structure of zinc free A14E, B25H, B29K(N(eps)-[2-(2-[2-(2-[2-(Octadecandioyl-gamma-Glu)amino]ethoxy)ethoxy]acetylamino)ethoxy]ethoxy)acetyl]), desB27, desB30 human insulin 分子名称: IMIDAZOLE, Insulin, KUT [2-(2-[2-(2-[2-(Octadecandioyl-gamma-Glu)amino]ethoxy)ethoxy]acetylamino)ethoxy]ethoxy)acetyl] 著者 Johansson, E. 登録日 2019-06-28 公開日 2020-07-15 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 Molecular engineering of safe and efficacious oral basal insulin. Nat Commun, 11, 2020
6S4I	Crystal structure of zinc free A14E, B25H, B29K(N(eps)-[2-(2-[2-(2-[2-(Octadecandioyl-gamma-Glu)amino]ethoxy)ethoxy]acetylamino)ethoxy]ethoxy)acetyl]), desB30 human insulin 分子名称: Insulin, NITRATE ION 著者 Johansson, E. 登録日 2019-06-28 公開日 2020-07-15 最終更新日 2020-08-12 実験手法 X-RAY DIFFRACTION (1.511 Å) 主引用文献 Molecular engineering of safe and efficacious oral basal insulin. Nat Commun, 11, 2020
6RVA	STRUCTURE OF [ASP58]-IGF-I ANALOGUE 分子名称: Insulin-like growth factor I 著者 Jiracek, J, Zakova, L, Socha, O. 登録日 2019-05-31 公開日 2019-10-02 最終更新日 2023-06-14 実験手法 SOLUTION NMR 主引用文献 Mutations at hypothetical binding site 2 in insulin and insulin-like growth factors 1 and 2 result in receptor- and hormone-specific responses. J.Biol.Chem., 294, 2019
5AIY	R6 HUMAN INSULIN HEXAMER (SYMMETRIC), NMR, 'RED' SUBSTATE, AVERAGE STRUCTURE 分子名称: PHENOL, PROTEIN (INSULIN) 著者 O'Donoghue, S.I, Chang, X, Abseher, R, Nilges, M, Led, J.J. 登録日 1998-12-29 公開日 2000-02-28 最終更新日 2023-12-27 実験手法 SOLUTION NMR 主引用文献 Unraveling the symmetry ambiguity in a hexamer: calculation of the R6 human insulin structure. J.Biomol.NMR, 16, 2000
6QRH	High pressure structure of bovine insulin (100 MPa) 分子名称: Insulin 著者 Kurpiewska, K, Milaczewska, A, Lewinski, K. 登録日 2019-02-19 公開日 2019-02-27 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.152 Å) 主引用文献 Insulin conformational changes under high pressure in structural studies and molecular dynamics simulations J.Mol.Struct., 2020
6QRK	High pressure structure of bovine insulin (200 MPa) 分子名称: Insulin 著者 Kurpiewska, K, Milaczewska, A, Lewinski, K. 登録日 2019-02-19 公開日 2019-03-06 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.102 Å) 主引用文献 Insulin conformational changes under high pressure in structural studies and molecular dynamics simulations J.Mol.Struct., 2020
5CO6	Crystal structure of human zinc insulin at pH 6.5 分子名称: CHLORIDE ION, Insulin, MAGNESIUM ION, ... 著者 Lima, L.M.T.R, PALMIERI, L.C. 登録日 2015-07-19 公開日 2015-08-26 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Crystal structure of human zinc insulin at pH 6.5 To Be Published
6QQG	High pressure structure of bovine insulin (60 MPa) 分子名称: Insulin 著者 Kurpiewska, K, Milaczewska, A, Lewinski, K. 登録日 2019-02-18 公開日 2019-03-06 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.149 Å) 主引用文献 Insulin conformational changes under high pressure in structural studies and molecular dynamics simulations J.Mol.Struct., 2020
5AZZ	Crystal structure of seleno-insulin 分子名称: Insulin A chain, Insulin B chain 著者 Watanabe, S, Okumura, M, Arai, K, Takei, T, Asahina, Y, Hojo, H, Iwaoka, M, Inaba, K. 登録日 2015-10-23 公開日 2017-05-03 最終更新日 2017-06-14 実験手法 X-RAY DIFFRACTION (1.45 Å) 主引用文献 Preparation of Selenoinsulin as a Long-Lasting Insulin Analogue. Angew. Chem. Int. Ed. Engl., 56, 2017
6S34	Zinc free, dimeric human insulin determined to 1.35 Angstrom resolution 分子名称: 1,2-ETHANEDIOL, Insulin A chain, Insulin B chain 著者 Johansson, E. 登録日 2019-06-24 公開日 2019-07-03 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.35 Å) 主引用文献 Zinc free, dimeric human insulin determined to 1.35 Angstrom resolution Not Published
5CO2	Crystalization of human zinc insulin at pH 5.5 分子名称: CHLORIDE ION, Insulin, ZINC ION 著者 Lima, L.M.T.R, Palmieri, L.C. 登録日 2015-07-19 公開日 2015-08-26 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Crystal structure of human zinc insulin at pH 5.5 To Be Published
5BPO	Human insulin with intra-chain chemical crosslink between modified B27 and B29 分子名称: Insulin 著者 Brzozowski, A.M, Turkenburg, J.P, Jiracek, J, Zakova, L. 登録日 2015-05-28 公開日 2016-02-03 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Rational steering of insulin binding specificity by intra-chain chemical crosslinking. Sci Rep, 6, 2016
6QQ7	Bovine insulin at ambient pressure 分子名称: Insulin 著者 Kurpiewska, K, Milaczewska, A, Lewinski, K. 登録日 2019-02-18 公開日 2019-02-27 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.65 Å) 主引用文献 Insulin conformational changes under high pressure in structural studies and molecular dynamics simulations J.Mol.Struct., 2020
5CNY	Crystal Structure of human zinc insulin at pH 5.5 分子名称: CHLORIDE ION, Insulin, ZINC ION 著者 Palmieri, L.C, Lima, L.M.T.R. 登録日 2015-07-18 公開日 2015-08-26 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Crystal Structure of human zinc insulin at pH 5.5 To Be Published
5BTS	Structural and biophysical characterization of a covalent insulin dimer formed during storage of neutral formulation of human insulin 分子名称: Insulin A chain, Insulin B chain 著者 Norrman, M, Hjorth, C.F. 登録日 2015-06-03 公開日 2016-03-09 最終更新日 2019-02-20 実験手法 X-RAY DIFFRACTION (1.77 Å) 主引用文献 Structure, Aggregation, and Activity of a Covalent Insulin Dimer Formed During Storage of Neutral Formulation of Human Insulin. J.Pharm.Sci., 105, 2016
3JSD	Insulin's biosynthesis and activity have opposing structural requirements: a new factor in neonatal diabetes mellitus 分子名称: CHLORIDE ION, Insulin A chain, Insulin B chain, ... 著者 Weiss, M.A, Wan, Z.L, Dodson, E.J, Liu, M, Xu, B, Hua, Q.X, Turkenburg, M, Whittingham, J, Nakagawa, S.H, Huang, K, Hu, S.Q, Jia, W.H, Wang, S.H, Brange, J, Whittaker, J, Arvan, P, Katsoyannis, P.G, Dodson, G.G. 登録日 2009-09-10 公開日 2010-09-15 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Insulin's biosynthesis and activity have opposing structural requirements: a new factor in neonatal diabetes mellitus To be Published
5CO9	Crystal structure of human zinc insulin at pH 6.5 分子名称: CHLORIDE ION, Insulin, ZINC ION 著者 Lima, L.M.T.R, Palmieri, L.C. 登録日 2015-07-20 公開日 2015-08-26 実験手法 X-RAY DIFFRACTION (1.92 Å) 主引用文献 Crystal structure of human zinc insulin at pH 6.5 To Be Published
3GF1	SOLUTION STRUCTURE OF HUMAN INSULIN-LIKE GROWTH FACTOR 1: A NUCLEAR MAGNETIC RESONANCE AND RESTRAINED MOLECULAR DYNAMICS STUDY 分子名称: INSULIN-LIKE GROWTH FACTOR I 著者 Cooke, R.M, Harvey, T.S, Campbell, I.D. 登録日 1991-01-24 公開日 1993-04-15 最終更新日 2022-03-16 実験手法 SOLUTION NMR 主引用文献 Solution structure of human insulin-like growth factor 1: a nuclear magnetic resonance and restrained molecular dynamics study. Biochemistry, 30, 1991
1MHI	THREE-DIMENSIONAL SOLUTION STRUCTURE OF AN INSULIN DIMER. A STUDY OF THE B9(ASP) MUTANT OF HUMAN INSULIN USING NUCLEAR MAGNETIC RESONANCE DISTANCE GEOMETRY AND RESTRAINED MOLECULAR DYNAMICS 分子名称: INSULIN 著者 Jorgensen, A.M.M, Kristensen, S.M, Led, J.J, Balschmidt, P. 登録日 1994-11-30 公開日 1995-10-15 最終更新日 2017-11-29 実験手法 SOLUTION NMR 主引用文献 Three-dimensional solution structure of an insulin dimer. A study of the B9(Asp) mutant of human insulin using nuclear magnetic resonance, distance geometry and restrained molecular dynamics. J.Mol.Biol., 227, 1992
1MPJ	X-RAY CRYSTALLOGRAPHIC STUDIES ON HEXAMERIC INSULINS IN THE PRESENCE OF HELIX-STABILIZING AGENTS, THIOCYANATE, METHYLPARABEN AND PHENOL 分子名称: CHLORIDE ION, PHENOL, PHENOL INSULIN, ... 著者 Whittingham, J.L, Dodson, E.J, Moody, P.C.E, Dodson, G.G. 登録日 1995-09-13 公開日 1996-01-29 最終更新日 2011-07-13 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 X-ray crystallographic studies on hexameric insulins in the presence of helix-stabilizing agents, thiocyanate, methylparaben, and phenol. Biochemistry, 34, 1995

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