4NN7
| Cytokine receptor complex - Crystal form 2 | Descriptor: | Cytokine receptor-like factor 2, Interleukin-7 receptor subunit alpha, Thymic stromal lymphopoietin | Authors: | Verstraete, K, van Schie, L, Savvides, S.N. | Deposit date: | 2013-11-16 | Release date: | 2014-03-19 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (3.775 Å) | Cite: | Structural basis of the proinflammatory signaling complex mediated by TSLP. Nat.Struct.Mol.Biol., 21, 2014
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7XGD
| Cryo-EM structure of Apo-IGF1R map 1 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Insulin-like growth factor 1 receptor | Authors: | Zhang, X, Wu, C. | Deposit date: | 2022-04-04 | Release date: | 2023-04-12 | Method: | ELECTRON MICROSCOPY (4 Å) | Cite: | Cryo-EM structure of Apo-IGF1R To Be Published
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7XLC
| conformation II of apo-IGF1R states | Descriptor: | Insulin-like growth factor 1 receptor | Authors: | Xi, Z, Cang, W. | Deposit date: | 2022-04-21 | Release date: | 2023-04-26 | Method: | ELECTRON MICROSCOPY (5 Å) | Cite: | conformation II of apo-IGF1R states To Be Published
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7YQ3
| human insulin receptor bound with A43 DNA aptamer and insulin | Descriptor: | IR-A43 aptamer, Insulin A chain, Insulin, ... | Authors: | Kim, J, Yunn, N, Ryu, S, Cho, Y. | Deposit date: | 2022-08-05 | Release date: | 2022-11-09 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Functional selectivity of insulin receptor revealed by aptamer-trapped receptor structures Nat Commun, 13, 2022
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7YQ4
| human insulin receptor bound with A62 DNA aptamer and insulin - locally refined | Descriptor: | IR-A62 aptamer, Insulin A chain, Insulin, ... | Authors: | Kim, J, Yunn, N, Ryu, S, Cho, Y. | Deposit date: | 2022-08-05 | Release date: | 2022-11-09 | Method: | ELECTRON MICROSCOPY (3.95 Å) | Cite: | Functional selectivity of insulin receptor revealed by aptamer-trapped receptor structures Nat Commun, 13, 2022
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7YQ6
| human insulin receptor bound with A62 DNA aptamer | Descriptor: | IR-A62 aptamer, Isoform Short of Insulin receptor | Authors: | Kim, J, Yunn, N, Ryu, S, Cho, Y. | Deposit date: | 2022-08-05 | Release date: | 2022-11-09 | Method: | ELECTRON MICROSCOPY (4.18 Å) | Cite: | Functional selectivity of insulin receptor revealed by aptamer-trapped receptor structures Nat Commun, 13, 2022
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7YQ5
| human insulin receptor bound with A62 DNA aptamer and insulin | Descriptor: | IR-A62 aptamer, Insulin A chain, Insulin, ... | Authors: | Kim, J, Yunn, N, Ryu, S, Cho, Y. | Deposit date: | 2022-08-05 | Release date: | 2022-11-09 | Method: | ELECTRON MICROSCOPY (4.27 Å) | Cite: | Functional selectivity of insulin receptor revealed by aptamer-trapped receptor structures Nat Commun, 13, 2022
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7YRR
| Cryo-EM structure of IGF1R with two IGF1 complex | Descriptor: | Insulin-like growth factor 1 receptor, Isoform 3 of Insulin-like growth factor I | Authors: | Xi, Z, Cang, W. | Deposit date: | 2022-08-10 | Release date: | 2023-08-16 | Method: | ELECTRON MICROSCOPY (4.3 Å) | Cite: | Cryo-EM structure of IGF1R with two IGF1 complex at 4.3 angstroms resolution To Be Published
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7Z0L
| IL-27 signalling complex | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Interleukin-27 receptor subunit alpha, ... | Authors: | Jin, Y, Gardner, S, Bubeck, D. | Deposit date: | 2022-02-23 | Release date: | 2022-07-27 | Last modified: | 2022-10-19 | Method: | ELECTRON MICROSCOPY (4 Å) | Cite: | Structural insights into the assembly and activation of the IL-27 signaling complex. Embo Rep., 23, 2022
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8A1F
| Human PTPRK N-terminal domains MAM-Ig-FN1 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Hay, I.M, Graham, S.C, Sharpe, H.J, Deane, J.E. | Deposit date: | 2022-06-01 | Release date: | 2023-03-15 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Determinants of receptor tyrosine phosphatase homophilic adhesion: Structural comparison of PTPRK and PTPRM extracellular domains. J.Biol.Chem., 299, 2023
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1ZLG
| Solution structure of the extracellular matrix protein anosmin-1 | Descriptor: | Anosmin 1 | Authors: | Hu, Y, Sun, Z, Eaton, J.T, Bouloux, P.M, Perkins, S.J. | Deposit date: | 2005-05-06 | Release date: | 2006-05-09 | Last modified: | 2022-12-21 | Method: | SOLUTION SCATTERING | Cite: | Extended and Flexible Domain Solution Structure of the Extracellular Matrix Protein Anosmin-1 by X-ray Scattering, Analytical Ultracentrifugation and Constrained Modelling. J.Mol.Biol., 350, 2005
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2AEW
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4UI2
| Crystal structure of the ternary RGMB-BMP2-NEO1 complex | Descriptor: | ACETATE ION, BONE MORPHOGENETIC PROTEIN 2, BMP2, ... | Authors: | Healey, E.G, Bishop, B, Elegheert, J, Bell, C.H, Padilla-Parra, S, Siebold, C. | Deposit date: | 2015-03-27 | Release date: | 2015-05-06 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (3.15 Å) | Cite: | Repulsive Guidance Molecule is a Structural Bridge between Neogenin and Bone Morphogenetic Protein. Nat.Struct.Mol.Biol., 22, 2015
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5DC0
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5DC9
| CRYSTAL STRUCTURE OF MONOBODY AS25/ABL1 SH2 DOMAIN COMPLEX, CRYSTAL B | Descriptor: | AS25 monobody, GLYCEROL, IMIDAZOLE, ... | Authors: | Wojcik, J.B, Koide, A, Koide, S. | Deposit date: | 2015-08-23 | Release date: | 2016-03-02 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (1.56 Å) | Cite: | Allosteric Inhibition of Bcr-Abl Kinase by High Affinity Monobody Inhibitors Directed to the Src Homology 2 (SH2)-Kinase Interface. J.Biol.Chem., 291, 2016
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6Z3M
| Repulsive Guidance Molecule B (RGMB) in complex with Growth Differentiation Factor 5 (GDF5) and Neogenin 1 (NEO1). | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Growth/differentiation factor 5, Neogenin, ... | Authors: | Malinauskas, T, Peer, T.V, Bishop, B, Muller, T.D, Siebold, C. | Deposit date: | 2020-05-21 | Release date: | 2020-07-01 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (5.501 Å) | Cite: | Repulsive guidance molecules lock growth differentiation factor 5 in an inhibitory complex. Proc.Natl.Acad.Sci.USA, 117, 2020
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5DC4
| CRYSTAL STRUCTURE OF MONOBODY AS25/ABL1 SH2 DOMAIN COMPLEX, CRYSTAL A | Descriptor: | AS25 monobody, GLYCEROL, Tyrosine-protein kinase ABL1 | Authors: | Wojcik, J.B, Koide, A, Koide, S. | Deposit date: | 2015-08-23 | Release date: | 2016-03-02 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (1.48 Å) | Cite: | Allosteric Inhibition of Bcr-Abl Kinase by High Affinity Monobody Inhibitors Directed to the Src Homology 2 (SH2)-Kinase Interface. J.Biol.Chem., 291, 2016
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4JEG
| Crystal Structure of Monobody CS1/SHP2 C-SH2 Domain Complex | Descriptor: | Monobody CS1, Tyrosine-protein phosphatase non-receptor type 11 | Authors: | Sha, F, Koide, S. | Deposit date: | 2013-02-26 | Release date: | 2013-08-28 | Last modified: | 2014-03-12 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Dissection of the BCR-ABL signaling network using highly specific monobody inhibitors to the SHP2 SH2 domains. Proc.Natl.Acad.Sci.USA, 110, 2013
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4JE4
| Crystal Structure of Monobody NSa1/SHP2 N-SH2 Domain Complex | Descriptor: | Monobody NSa1, Tyrosine-protein phosphatase non-receptor type 11 | Authors: | Sha, F, Koide, S. | Deposit date: | 2013-02-26 | Release date: | 2013-08-28 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.31 Å) | Cite: | Dissection of the BCR-ABL signaling network using highly specific monobody inhibitors to the SHP2 SH2 domains. Proc.Natl.Acad.Sci.USA, 110, 2013
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