4JE4
Crystal Structure of Monobody NSa1/SHP2 N-SH2 Domain Complex
Summary for 4JE4
Entry DOI | 10.2210/pdb4je4/pdb |
Related | 4JEG |
Descriptor | Tyrosine-protein phosphatase non-receptor type 11, Monobody NSa1 (3 entities in total) |
Functional Keywords | engineered binding protein, shp2 sh2-monobody complex, phosphatase, phosphotyrosine binding, phosphorylation, signaling protein-protein binding complex, signaling protein/protein binding |
Biological source | Homo sapiens (human) More |
Cellular location | Cytoplasm: Q06124 |
Total number of polymer chains | 2 |
Total formula weight | 22233.82 |
Authors | |
Primary citation | Sha, F.,Gencer, E.B.,Georgeon, S.,Koide, A.,Yasui, N.,Koide, S.,Hantschel, O. Dissection of the BCR-ABL signaling network using highly specific monobody inhibitors to the SHP2 SH2 domains. Proc.Natl.Acad.Sci.USA, 110:14924-14929, 2013 Cited by PubMed: 23980151DOI: 10.1073/pnas.1303640110 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.31 Å) |
Structure validation
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