4JEG

Crystal Structure of Monobody CS1/SHP2 C-SH2 Domain Complex

Summary for 4JEG

• Entry DOI: 10.2210/pdb4jeg/pdb
• Related: 4JE4
• Descriptor: Tyrosine-protein phosphatase non-receptor type 11, Monobody CS1 (3 entities in total)
• Functional Keywords: engineered binding protein, shp2 sh2-monobody complex, phosphatase, phosphotyrosine binding, phosphorylation, signaling protein-protein binding complex, signaling protein/protein binding
• Biological source: Homo sapiens (human); More
• Cellular location: Cytoplasm: Q06124
• Total number of polymer chains: 2
• Total formula weight: 24477.35

Authors

Sha, F.,Koide, S. (deposition date: 2013-02-26, release date: 2013-08-28, Last modification date: 2014-03-12)

• Primary citation: Sha, F.,Gencer, E.B.,Georgeon, S.,Koide, A.,Yasui, N.,Koide, S.,Hantschel, O.; Dissection of the BCR-ABL signaling network using highly specific monobody inhibitors to the SHP2 SH2 domains.; Proc.Natl.Acad.Sci.USA, 110:14924-14929, 2013; PubMed: 23980151; DOI: 10.1073/pnas.1303640110

Experimental method

X-RAY DIFFRACTION (2.3 Å)