PDB: 522 resultsInfo pagesStatus searchChemie searchBIRD

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8DGQ	Crystal structure of p120RasGAP SH2-SH3-SH2 in complex with p190RhoGAP doubly phosphorylated peptide Descriptor: MALONATE ION, Ras GTPase-activating protein 1, Rho GTPase-activating protein 35 Authors: Stiegler, A.L, Vish, K.J, Boggon, T.J. Deposit date: 2022-06-24 Release date: 2022-11-02 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (1.95 Å) Cite: Tandem engagement of phosphotyrosines by the dual SH2 domains of p120RasGAP. Structure, 30, 2022
3EHR	Crystal Structure of Human Osteoclast Stimulating Factor Descriptor: Osteoclast-stimulating factor 1 Authors: Tong, S, Zhou, H, Gao, Y, Zhu, Z, Zhang, X, Teng, M, Niu, L. Deposit date: 2008-09-14 Release date: 2009-08-04 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (1.95 Å) Cite: Crystal structure of human osteoclast stimulating factor Proteins, 75, 2009
6A9C	Crystal Structure c-terminal SH3 domain of Myosin IB from Entamoeba histolytica bound to EhFP10(GEF) peptide. Descriptor: Peptide from Rho guanine nucleotide exchange factor, SULFATE ION, Unconventional myosin IB Authors: Gautam, G, Gourinath, S. Deposit date: 2018-07-13 Release date: 2019-06-12 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (1.98 Å) Cite: EhFP10: A FYVE family GEF interacts with myosin IB to regulate cytoskeletal dynamics during endocytosis in Entamoeba histolytica. Plos Pathog., 15, 2019
3UF4	Crystal structure of a SH3 and SH2 domains of FYN protein (Proto-concogene Tyrosine-protein kinase Fyn) from Mus musculus at 1.98 A resolution Descriptor: CHLORIDE ION, GLYCEROL, SODIUM ION, ... Authors: Joint Center for Structural Genomics (JCSG), Partnership for T-Cell Biology (TCELL) Deposit date: 2011-10-31 Release date: 2011-12-07 Last modified: 2023-02-01 Method: X-RAY DIFFRACTION (1.98 Å) Cite: Crystal structure of a SH3 and SH2 domains of FYN protein (Proto-concogene Tyrosine-protein kinase Fyn) from Mus musculus at 1.98 A resolution To be published
1HD3	A-SPECTRIN SH3 DOMAIN F52Y MUTANT Descriptor: GLYCEROL, SPECTRIN ALPHA CHAIN, SULFATE ION Authors: Vega, M.C, Viguera, A.R, Serrano, L. Deposit date: 2000-11-06 Release date: 2001-11-01 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (1.98 Å) Cite: Unspecific Hydrophobic Stabilization of Folding Transition States Proc.Natl.Acad.Sci.USA, 99, 2002
3REA	HIV-1 Nef protein in complex with engineered Hck-SH3 domain Descriptor: Protein Nef, Tyrosine-protein kinase HCK Authors: Schulte, A, Blankenfeldt, W, Geyer, M. Deposit date: 2011-04-04 Release date: 2011-06-01 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (2 Å) Cite: Molecular design, functional characterization and structural basis of a protein inhibitor against the HIV-1 pathogenicity factor Nef. PLoS ONE, 6, 2011
1ABO	CRYSTAL STRUCTURE OF THE COMPLEX OF THE ABL TYROSINE KINASE SH3 DOMAIN WITH 3BP-1 SYNTHETIC PEPTIDE Descriptor: 3BP-1 SYNTHETIC PEPTIDE, 10 RESIDUES, ABL TYROSINE KINASE, ... Authors: Musacchio, A, Wilmanns, M, Saraste, M. Deposit date: 1995-05-19 Release date: 1995-10-15 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (2 Å) Cite: High-resolution crystal structures of tyrosine kinase SH3 domains complexed with proline-rich peptides. Nat.Struct.Biol., 1, 1994
7PVZ	Crystal structure of the intertwined dimer of the c-Src SH3 domain E93V-S94A-R95S-T96G mutant Descriptor: Isoform 2 of Proto-oncogene tyrosine-protein kinase Src Authors: Camara-Artigas, A, Salinas Garcia, M.C. Deposit date: 2021-10-05 Release date: 2022-11-16 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (2 Å) Cite: The effect of the hinge loops composition in the domain swapping of the SH3 domain To be published
1I0C	EPS8 SH3 CLOSED MONOMER Descriptor: EPIDERMAL GROWTH FACTOR RECEPTOR KINASE SUBSTRATE EPS8 Authors: Kishan, K.V.R, Newcomer, M.E. Deposit date: 2001-01-29 Release date: 2001-05-09 Last modified: 2023-08-09 Method: X-RAY DIFFRACTION (2 Å) Cite: Effect of pH and salt bridges on structural assembly: molecular structures of the monomer and intertwined dimer of the Eps8 SH3 domain. Protein Sci., 10, 2001
1JXM	CRYSTAL STRUCTURE OF THE GMP BOUND SH3-HOOK-GK FRAGMENT OF PSD-95 Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, GUANIDINE, GUANOSINE-5'-MONOPHOSPHATE, ... Authors: Tavares, G.A, Panepucci, E.H, Brunger, A.T. Deposit date: 2001-09-07 Release date: 2002-01-16 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (2 Å) Cite: Structural characterization of the intramolecular interaction between the SH3 and guanylate kinase domains of PSD-95. Mol.Cell, 8, 2001
7Z3J	Structure of crystallisable rat Phospholipase C gamma 1 in complex with inositol 1,4,5-trisphosphate Descriptor: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1, CALCIUM ION, D-MYO-INOSITOL-1,4,5-TRIPHOSPHATE, ... Authors: Pinotsis, N, Bunney, T.D, Katan, M. Deposit date: 2022-03-02 Release date: 2022-07-20 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (2 Å) Cite: Characterization of the membrane interactions of phospholipase C gamma reveals key features of the active enzyme. Sci Adv, 8, 2022
5NP3	Abl2 SH3 Descriptor: Abelson tyrosine-protein kinase 2 Authors: Mero, B, Radnai, L, Gogl, G, Leveles, I, Buday, L. Deposit date: 2017-04-13 Release date: 2018-05-16 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (2 Å) Cite: Structural insights into the tyrosine phosphorylation-mediated inhibition of SH3 domain-ligand interactions. J.Biol.Chem., 294, 2019
4HXJ	Crystal structure of SH3:RGT complex Descriptor: C-terminal 3-mer peptide from Integrin beta-3, Proto-oncogene tyrosine-protein kinase Src Authors: Xiao, R, Meng, G. Deposit date: 2012-11-11 Release date: 2012-11-28 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (2 Å) Cite: Structural framework of c-Src activation by integrin beta 3 Blood, 121, 2013
1W6X	SH3 domain of p40phox, component of the NADPH oxidase Descriptor: NEUTROPHIL CYTOSOL FACTOR 4 Authors: Massenet, C, Chenavas, S, Cohen-Addad, C, Dagher, M.-C, Brandolin, G, Pebay-Peyroula, E, Fieschi, F. Deposit date: 2004-08-24 Release date: 2005-01-18 Last modified: 2019-05-08 Method: X-RAY DIFFRACTION (2 Å) Cite: Effects of P47Phox C-Terminus Phosphorylation on Binding Interactions with P40Phox and P67Phox: Structural and Functional Comparison of P40Phox P67Phox SH3 Domains J.Biol.Chem., 280, 2005
1QCF	CRYSTAL STRUCTURE OF HCK IN COMPLEX WITH A SRC FAMILY-SELECTIVE TYROSINE KINASE INHIBITOR Descriptor: 1-TER-BUTYL-3-P-TOLYL-1H-PYRAZOLO[3,4-D]PYRIMIDIN-4-YLAMINE, Tyrosine-protein kinase HCK Authors: Schindler, T, Sicheri, F, Pico, A, Gazit, A, Levitzki, A, Kuriyan, J. Deposit date: 1999-05-04 Release date: 1999-06-08 Last modified: 2022-12-21 Method: X-RAY DIFFRACTION (2 Å) Cite: Crystal structure of Hck in complex with a Src family-selective tyrosine kinase inhibitor. Mol.Cell, 3, 1999
1QKW	Alpha-spectrin Src Homology 3 domain, N47G mutant in the distal loop. Descriptor: ALPHA II SPECTRIN, GLYCEROL, SULFATE ION Authors: Vega, M.C, Martinez, J, Serrano, L. Deposit date: 1999-08-16 Release date: 2000-08-18 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (2 Å) Cite: Thermodynamic and structural characterization of Asn and Ala residues in the disallowed II' region of the Ramachandran plot. Protein Sci., 9, 2000
4OMQ	Crystal structure of the intertwined dimer of the c-Src tyrosine kinase SH3 domain mutant S94A Descriptor: DI(HYDROXYETHYL)ETHER, Proto-oncogene tyrosine-protein kinase Src, SULFATE ION, ... Authors: Camara-Artigas, A, Bacarizo, J. Deposit date: 2014-01-27 Release date: 2015-01-28 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (2 Å) Cite: The role of Gutamine 128 of the SH3 domain of the c-Src tyrosine kinase in 3D domain swapping and amyloid formation To be Published
4OMP	Crystal structure of the intertwined dimer of the c-Src tyrosine kinase SH3 domain mutant Q128K Descriptor: DI(HYDROXYETHYL)ETHER, Proto-oncogene tyrosine-protein kinase Src, TRIETHYLENE GLYCOL Authors: Camara-Artigas, A, Bacarizo, J. Deposit date: 2014-01-27 Release date: 2014-12-10 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (2 Å) Cite: Electrostatic Effects in the Folding of the SH3 Domain of the c-Src Tyrosine Kinase: pH-Dependence in 3D-Domain Swapping and Amyloid Formation. Plos One, 9, 2014
5FWD	Crystal Structure of Mus musculus Protein Arginine Methyltransferase 2 with CP2 Descriptor: 1,2-ETHANEDIOL, 9-(7-{[amino(iminio)methyl]amino}-5,6,7-trideoxy-beta-D-ribo-heptofuranosyl)-9H-purin-6-amine, CALCIUM ION, ... Authors: Cura, V, Troffer-Charlier, N, Marechal, N, Bonnefond, L, Cavarelli, J. Deposit date: 2016-02-12 Release date: 2017-03-01 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (2 Å) Cite: Structural Studies of Protein Arginine Methyltransferase 2 Reveal its Interactions with Potential Substrates and Inhibitors. FEBS J., 284, 2017
4ORZ	HIV-1 Nef protein in complex with single domain antibody sdAb19 and an engineered Hck SH3 domain Descriptor: Protein Nef, Tyrosine-protein kinase HCK, single domain antibody sdAb19 Authors: Geyer, M, Lulf, S. Deposit date: 2014-02-12 Release date: 2014-03-26 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (2 Å) Cite: Structural basis for the inhibition of HIV-1 Nef by a high-affinity binding single-domain antibody. Retrovirology, 11, 2014
1SEM	STRUCTURAL DETERMINANTS OF PEPTIDE-BINDING ORIENTATION AND OF SEQUENCE SPECIFICITY IN SH3 DOMAINS Descriptor: 10-RESIDUE PROLINE-RICH PEPTIDE FROM MSOS (ACE-PRO-PRO-PRO-VAL-PRO-PRO-ARG-ARG-ARG), SEM-5 Authors: Lim, W.A, Richards, F.M, Fox, R.O. Deposit date: 1995-03-28 Release date: 1995-07-10 Last modified: 2011-07-13 Method: X-RAY DIFFRACTION (2 Å) Cite: Structural determinants of peptide-binding orientation and of sequence specificity in SH3 domains. Nature, 372, 1994
1BK2	A-SPECTRIN SH3 DOMAIN D48G MUTANT Descriptor: A-SPECTRIN Authors: Martinez, J.C, Pisabarro, M.T, Serrano, L. Deposit date: 1998-07-14 Release date: 1999-02-16 Last modified: 2023-08-02 Method: X-RAY DIFFRACTION (2.01 Å) Cite: Obligatory steps in protein folding and the conformational diversity of the transition state. Nat.Struct.Biol., 5, 1998
1E6H	A-SPECTRIN SH3 DOMAIN A11V, M25I, V44I, V58L MUTANTS Descriptor: SPECTRIN ALPHA CHAIN Authors: Vega, M.C, Serrano, L. Deposit date: 2000-08-17 Release date: 2002-05-23 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (2.01 Å) Cite: Conformational Strain in the Hydrophobic Core and its Implications for Protein Folding and Design Nat.Struct.Biol., 9, 2002
3QWX	CED-2 1-174 Descriptor: Cell death abnormality protein 2, SULFATE ION Authors: Kang, Y, Sun, J, Liu, Y. Deposit date: 2011-02-28 Release date: 2011-06-08 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (2.01 Å) Cite: Crystal structure of the cell corpse engulfment protein CED-2 in Caenorhabditis elegans. Biochem.Biophys.Res.Commun., 410, 2011
1TUC	ALPHA-SPECTRIN SRC HOMOLOGY 3 DOMAIN, CIRCULAR PERMUTANT, CUT AT S19-P20 Descriptor: ALPHA-SPECTRIN Authors: Wilmanns, M, Serrano, L, Viguera, A.R. Deposit date: 1996-02-29 Release date: 1996-08-01 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (2.02 Å) Cite: The order of secondary structure elements does not determine the structure of a protein but does affect its folding kinetics. J.Mol.Biol., 247, 1995

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