PDB: 593 resultsInfo pagesStatus searchChemie searchBIRD

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2ECD	Solution structure of the human ABL2 SH2 domain Descriptor: Tyrosine-protein kinase ABL2 Authors: Kasai, T, Koshiba, S, Inoue, M, Kigawa, T, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) Deposit date: 2007-02-13 Release date: 2008-02-19 Last modified: 2022-03-09 Method: SOLUTION NMR Cite: Solution structure of the human ABL2 SH2 domain To be Published
2EOB	Solution structure of the second SH2 domain from rat PLC gamma-2 Descriptor: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 2 Authors: Sano, R, Hayashi, F, Nagashima, T, Yoshida, M, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) Deposit date: 2007-03-29 Release date: 2008-04-01 Last modified: 2022-03-09 Method: SOLUTION NMR Cite: Solution structure of the second SH2 domain from rat PLC gamma-2 To be Published
2EO6	Solution structure of the SH2 domain from mouse B-cell linker protein BLNK Descriptor: B-cell linker protein Authors: Sano, R, Hayashi, F, Kurosaki, C, Yoshida, M, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) Deposit date: 2007-03-29 Release date: 2008-04-01 Last modified: 2022-03-09 Method: SOLUTION NMR Cite: Solution structure of the SH2 domain from mouse B-cell linker protein BLNK To be Published
2EYV	SH2 domain of CT10-Regulated Kinase Descriptor: v-crk sarcoma virus CT10 oncogene homolog isoform a Authors: Kobashigawa, Y, Tanaka, S, Inagaki, F. Deposit date: 2005-11-10 Release date: 2006-11-10 Last modified: 2022-03-09 Method: SOLUTION NMR Cite: Structural basis for the transforming activity of human cancer-related signaling adaptor protein CRK. Nat.Struct.Mol.Biol., 14, 2007
2ETZ	The NMR minimized average structure of the Itk SH2 domain bound to a phosphopeptide Descriptor: Lymphocyte cytosolic protein 2 phosphopeptide fragment, Tyrosine-protein kinase ITK/TSK Authors: Sundd, M, Pletneva, E.V, Fulton, D.B, Andreotti, A.H. Deposit date: 2005-10-27 Release date: 2006-02-07 Last modified: 2022-03-09 Method: SOLUTION NMR Cite: Molecular Details of Itk Activation by Prolyl Isomerization and Phospholigand Binding: The NMR Structure of the Itk SH2 Domain Bound to a Phosphopeptide. J.Mol.Biol., 357, 2006
2EU0	The NMR ensemble structure of the Itk SH2 domain bound to a phosphopeptide Descriptor: Lymphocyte cytosolic protein 2 phosphopeptide fragment, Tyrosine-protein kinase ITK/TSK Authors: Sundd, M, Pletneva, E.V, Fulton, D.B, Andreotti, A.H. Deposit date: 2005-10-27 Release date: 2006-02-07 Last modified: 2022-03-09 Method: SOLUTION NMR Cite: Molecular Details of Itk Activation by Prolyl Isomerization and Phospholigand Binding: The NMR Structure of the Itk SH2 Domain Bound to a Phosphopeptide. J.Mol.Biol., 357, 2006
2FCI	Structural basis for the requirement of two phosphotyrosines in signaling mediated by Syk tyrosine kinase Descriptor: C-termainl SH2 domain from phospholipase C-gamma-1 comprising residues 663-759, Doubly phosphorylated peptide derived from Syk kinase comprising residues 338-350 Authors: Groesch, T.D, Zhou, F, Mattila, S, Geahlen, R.L, Post, C.B. Deposit date: 2005-12-12 Release date: 2006-01-31 Last modified: 2023-11-15 Method: SOLUTION NMR Cite: Structural basis for the requirement of two phosphotyrosine residues in signaling mediated by syk tyrosine kinase J.Mol.Biol., 356, 2006
2GE9	Solution Structures of the SH2 domain of Bruton's Tyrosine Kinase Descriptor: Tyrosine-protein kinase BTK Authors: Cheng, J.-W, Huang, K.-C. Deposit date: 2006-03-18 Release date: 2006-10-24 Last modified: 2022-03-09 Method: SOLUTION NMR Cite: Solution structure and phosphopeptide binding of the SH2 domain from the human Bruton's tyrosine kinase J.Biomol.Nmr, 36, 2006
2H5K	Crystal Structure of Complex Between the Domain-Swapped Dimeric Grb2 SH2 Domain and Shc-Derived Ligand, Ac-NH-pTyr-Val-Asn-NH2 Descriptor: CACODYLATE ION, Growth factor receptor-bound protein 2, Shc-Derived Ligand Authors: Benfield, A.P, Whiddon, B.B, Martin, S.F. Deposit date: 2006-05-26 Release date: 2006-08-15 Last modified: 2017-10-18 Method: X-RAY DIFFRACTION (3.25 Å) Cite: Structural and energetic aspects of Grb2-SH2 domain-swapping. Arch.Biochem.Biophys., 462, 2007
2GSB	Solution structure of the second SH2 domain of human Ras GTPase-activating protein 1 Descriptor: Ras GTPase-activating protein 1 Authors: Kurosaki, C, Suetake, T, Yoshida, M, Hayashi, F, Yokoyma, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) Deposit date: 2006-04-26 Release date: 2007-05-01 Last modified: 2022-03-09 Method: SOLUTION NMR Cite: Solution structure of the second SH2 domain of human Ras GTPase-activating protein 1 To be Published
2H46	Native domain-swapped dimer crystal structure of the Grb2 SH2 domain Descriptor: GLYCEROL, Growth Receptor Binding Protein 2 Authors: Benfield, A.P, Martin, S.F, Whiddon, B.B. Deposit date: 2006-05-23 Release date: 2006-06-06 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Structural and energetic aspects of Grb2-SH2 domain-swapping. Arch.Biochem.Biophys., 462, 2007
2HDV	Crystal structure of the Src Homology-2 domain of the adapter protein SH2-B Descriptor: SH2-B PH domain containing signaling mediator 1 gamma isoform Authors: Hu, J, Hubbard, S.R. Deposit date: 2006-06-20 Release date: 2006-08-08 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (2 Å) Cite: Structural Basis for Phosphotyrosine Recognition by the Src Homology-2 Domains of the Adapter Proteins SH2-B and APS. J.Mol.Biol., 361, 2006
2HDX	Crystal structure of the Src homology-2 domain of SH2-B in complex with Jak2 pTyr813 phosphopeptide Descriptor: Jak2 protein, SH2-B PH domain containing signaling mediator 1 gamma isoform Authors: Hu, J, Hubbard, S.R. Deposit date: 2006-06-21 Release date: 2006-08-08 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (2.35 Å) Cite: Structural Basis for Phosphotyrosine Recognition by the Src Homology-2 Domains of the Adapter Proteins SH2-B and APS. J.Mol.Biol., 361, 2006
2HMH	Crystal structure of SOCS3 in complex with gp130(pTyr757) phosphopeptide. Descriptor: Interleukin-6 receptor beta chain, Suppressor of cytokine signaling 3 Authors: Bergamin, E, Wu, J, Hubbard, S.R. Deposit date: 2006-07-11 Release date: 2006-08-15 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (2 Å) Cite: Structural basis for phosphotyrosine recognition by suppressor of cytokine signaling-3. Structure, 14, 2006
1JYR	Xray Structure of Grb2 SH2 Domain Complexed with a Phosphorylated Peptide Descriptor: GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2, peptide: PSpYVNVQN Authors: Nioche, P, Liu, W.-Q, Broutin, I, Charbonnier, F, Latreille, M.-T, Vidal, M, Roques, B, Garbay, C, Ducruix, A. Deposit date: 2001-09-13 Release date: 2002-03-13 Last modified: 2018-10-10 Method: X-RAY DIFFRACTION (1.55 Å) Cite: Crystal structures of the SH2 domain of Grb2: highlight on the binding of a new high-affinity inhibitor. J.Mol.Biol., 315, 2002
1JYU	Xray Structure of Grb2 SH2 Domain Descriptor: GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2 Authors: Nioche, P, Liu, W.-Q, Broutin, I, Charbonnier, F, Latreille, M.-T, Vidal, M, Roques, B, Garbay, C, Ducruix, A. Deposit date: 2001-09-13 Release date: 2002-03-13 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (2.75 Å) Cite: Crystal structures of the SH2 domain of Grb2: highlight on the binding of a new high-affinity inhibitor. J.Mol.Biol., 315, 2002
1JWO	Crystal Structure Analysis of the SH2 Domain of the Csk Homologous Kinase CHK Descriptor: Csk Homologous Kinase Authors: Murthy, T.V.S, Webster, G.D. Deposit date: 2001-09-04 Release date: 2001-09-12 Last modified: 2023-08-16 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Recognition of the HER-2/neu Receptor by the SH2 Domain of the Csk Homologous Kinase To be Published
1JYQ	Xray Structure of Grb2 SH2 Domain Complexed with a Highly Affine Phospho Peptide Descriptor: GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2, mAZ-pY-(alpha Me)pY-N-NH2 peptide inhibitor Authors: Nioche, P, Liu, W.-Q, Broutin, I, Charbonnier, F, Latreille, M.-T, Vidal, M, Roques, B, Garbay, C, Ducruix, A. Deposit date: 2001-09-13 Release date: 2002-03-13 Last modified: 2018-04-04 Method: X-RAY DIFFRACTION (2 Å) Cite: Crystal structures of the SH2 domain of Grb2: highlight on the binding of a new high-affinity inhibitor. J.Mol.Biol., 315, 2002
1KA7	SAP/SH2D1A bound to peptide n-Y-c Descriptor: SH2 DOMAIN PROTEIN 1A, peptide n-Y-c Authors: Hwang, P.M, Li, C, Morra, M, Lillywhite, J, Gertler, F, Terhorst, C, Kay, L.E, Pawson, T, Forman-Kay, J, Li, S.-C. Deposit date: 2001-10-31 Release date: 2001-11-07 Last modified: 2021-10-27 Method: SOLUTION NMR Cite: A "three-pronged" binding mechanism for the SAP/SH2D1A SH2 domain: structural basis and relevance to the XLP syndrome. EMBO J., 21, 2002
1KA6	SAP/SH2D1A bound to peptide n-pY Descriptor: SH2 DOMAIN PROTEIN 1A, peptide n-pY Authors: Hwang, P.M, Li, C, Morra, M, Lillywhite, J, Gertler, F, Terhorst, C, Kay, L.E, Pawson, T, Forman-Kay, J, Li, S.-C. Deposit date: 2001-10-31 Release date: 2001-11-07 Last modified: 2021-10-27 Method: SOLUTION NMR Cite: A "three-pronged" binding mechanism for the SAP/SH2D1A SH2 domain: structural basis and relevance to the XLP syndrome. EMBO J., 21, 2002
1KC2	structure of the triple (Lys(beta)D3Ala, Asp(beta)C8Ala, AspCD2Ala) mutant of the Src SH2 domain bound to the PQpYEEIPI peptide Descriptor: COBALT (II) ION, PQpYEEIPI peptide, Src Tyrosine kinase Authors: Lubman, O.Y, Waksman, G. Deposit date: 2001-11-07 Release date: 2002-04-17 Last modified: 2021-11-10 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Dissection of the energetic coupling across the Src SH2 domain-tyrosyl phosphopeptide interface. J.Mol.Biol., 316, 2002
1LCJ	SH2 (SRC HOMOLOGY-2) DOMAIN OF HUMAN P56-LCK TYROSINE KINASE COMPLEXED WITH THE 11 RESIDUE PHOSPHOTYROSYL PEPTIDE EPQPYEEIPIYL Descriptor: P56==LCK== TYROSINE KINASE, PHOSPHOPEPTIDE EPQ(PHOSPHO)YEEIPIYL Authors: Eck, M, Harrison, S. Deposit date: 1994-12-12 Release date: 1995-10-15 Last modified: 2011-07-13 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Recognition of a high-affinity phosphotyrosyl peptide by the Src homology-2 domain of p56lck. Nature, 362, 1993
1LKK	HUMAN P56-LCK TYROSINE KINASE SH2 DOMAIN IN COMPLEX WITH THE PHOSPHOTYROSYL PEPTIDE AC-PTYR-GLU-GLU-ILE (PYEEI PEPTIDE) Descriptor: ACETYL GROUP, HUMAN P56 TYROSINE KINASE, PHOSPHOTYROSYL PEPTIDE AC-PTYR-GLU-GLU-ILE Authors: Tong, L. Deposit date: 1995-11-10 Release date: 1996-03-08 Last modified: 2011-07-13 Method: X-RAY DIFFRACTION (1 Å) Cite: Crystal structures of the human p56lck SH2 domain in complex with two short phosphotyrosyl peptides at 1.0 A and 1.8 A resolution. J.Mol.Biol., 256, 1996
1LKL	HUMAN P56-LCK TYROSINE KINASE SH2 DOMAIN IN COMPLEX WITH THE PHOSPHOTYROSYL PEPTIDE AC-PTYR-GLU-GLU-GLY (PYEEG PEPTIDE) Descriptor: HUMAN P56 TYROSINE KINASE, PHOSPHOTYROSYL PEPTIDE AC-PTYR-GLU-GLU-GLY Authors: Tong, L. Deposit date: 1995-11-10 Release date: 1996-03-08 Last modified: 2011-07-13 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Crystal structures of the human p56lck SH2 domain in complex with two short phosphotyrosyl peptides at 1.0 A and 1.8 A resolution. J.Mol.Biol., 256, 1996
1LUI	NMR Structures of Itk SH2 domain, Pro287cis isoform, ensemble of 20 low energy structures Descriptor: Tyrosine-protein kinase ITK/TSK Authors: Mallis, R.J, Brazin, K.N, Fulton, B.F, Andreotti, A.M. Deposit date: 2002-05-22 Release date: 2002-11-27 Last modified: 2022-02-23 Method: SOLUTION NMR Cite: Structural characterization of a proline-driven conformational switch within the Itk SH2 domain Nat.Struct.Biol., 9, 2002

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