PDB: 266 resultsInfo pagesStatus searchChemie searchBIRD

---

5YK3	human Ragulator complex Descriptor: Ragulator complex protein LAMTOR1, Ragulator complex protein LAMTOR2, Ragulator complex protein LAMTOR3, ... Authors: Wu, G, Mu, Z. Deposit date: 2017-10-12 Release date: 2019-01-23 Last modified: 2024-03-27 Method: X-RAY DIFFRACTION (3.01 Å) Cite: Structural insight into the Ragulator complex which anchors mTORC1 to the lysosomal membrane Cell Discov, 3, 2017
5YK5	structure of the human Lamtor4-Lamtor5 complex Descriptor: Ragulator complex protein LAMTOR4, Ragulator complex protein LAMTOR5 Authors: Wu, G, Mu, Z. Deposit date: 2017-10-12 Release date: 2018-12-12 Last modified: 2024-03-27 Method: X-RAY DIFFRACTION (2.03 Å) Cite: Structural insight into the Ragulator complex which anchors mTORC1 to the lysosomal membrane Cell Discov, 3, 2017
6E7F	Crystal Structure of Human Inositol Polyphosphate Multikinase (IPMK) Catalytic Core Domain Descriptor: Inositol polyphosphate multikinase, SULFATE ION Authors: Blind, R, Seacrist, C. Deposit date: 2018-07-26 Release date: 2018-11-07 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Crystallographic and kinetic analyses of human IPMK reveal disordered domains modulate ATP binding and kinase activity. Sci Rep, 8, 2018
5ZXB	Crystal structure of ACK1 with compound 10d Descriptor: Activated CDC42 kinase 1, N-{3-[7-{[6-(4-acetylpiperazin-1-yl)pyridin-3-yl]amino}-1-methyl-2-oxo-1,4-dihydropyrimido[4,5-d]pyrimidin-3(2H)-yl]-4-methylphenyl}-3-(trifluoromethyl)benzamide Authors: Hong, E.M, Kim, H.L, Sim, T.B. Deposit date: 2018-05-18 Release date: 2018-09-26 Last modified: 2024-03-27 Method: X-RAY DIFFRACTION (2.198 Å) Cite: First SAR Study for Overriding NRAS Mutant Driven Acute Myeloid Leukemia. J. Med. Chem., 61, 2018
6BUU	Crystal structure of AKT1 (aa 144-480) with a bisubstrate Descriptor: GLY-ARG-PRO-ARG-THR-THR-ZXW-PHE-ALA-GLU, MANGANESE (II) ION, RAC-alpha serine/threonine-protein kinase, ... Authors: Chu, N, Gabelli, S.B, Cole, P.A. Deposit date: 2017-12-11 Release date: 2018-08-22 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Akt Kinase Activation Mechanisms Revealed Using Protein Semisynthesis. Cell, 174, 2018
5VOK	Crystal structure of the C7orf59-HBXIP dimer Descriptor: Ragulator complex protein LAMTOR4, Ragulator complex protein LAMTOR5 Authors: Rasheed, N, Nascimento, A.F.Z, Bar-Peled, L, Shen, K, Sabatini, D.M, Aparicio, R, Smetana, J.H.C. Deposit date: 2017-05-03 Release date: 2018-05-23 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (2.89 Å) Cite: C7orf59/Lamtor4 phosphorylation and structural flexibility modulate Ragulator assembly. Febs Open Bio, 2019
6FO1	Human R2TP subcomplex containing 1 RUVBL1-RUVBL2 hexamer bound to 1 RBD domain from RPAP3. Descriptor: ADENOSINE-5'-DIPHOSPHATE, RNA polymerase II-associated protein 3, RuvB-like 1, ... Authors: Martino, F, Munoz-Hernandez, H, Rodriguez, C.F, Pearl, L.H, Llorca, O. Deposit date: 2018-02-05 Release date: 2018-04-04 Last modified: 2019-12-11 Method: ELECTRON MICROSCOPY (3.57 Å) Cite: RPAP3 provides a flexible scaffold for coupling HSP90 to the human R2TP co-chaperone complex. Nat Commun, 9, 2018
6CHW	Estrogen Receptor Alpha Y537S covalently bound to antagonist H3B-5942. Descriptor: 1,2-ETHANEDIOL, 4-[(2-{4-[(1E)-1-(1H-indazol-5-yl)-2-phenylbut-1-en-1-yl]phenoxy}ethyl)amino]-N,N-dimethylbutanamide, DIMETHYL SULFOXIDE, ... Authors: Larsen, N.A. Deposit date: 2018-02-23 Release date: 2018-03-21 Last modified: 2020-02-26 Method: X-RAY DIFFRACTION (1.89 Å) Cite: Discovery of Selective Estrogen Receptor Covalent Antagonists for the Treatment of ER alphaWTand ER alphaMUTBreast Cancer. Cancer Discov, 8, 2018
5ZCS	4.9 Angstrom Cryo-EM structure of human mTOR complex 2 Descriptor: Rapamycin-insensitive companion of mTOR, Serine/threonine-protein kinase mTOR, Target of rapamycin complex 2 subunit MAPKAP1, ... Authors: Chen, X, Liu, M, Tian, Y, Wang, H, Wang, J, Xu, Y. Deposit date: 2018-02-20 Release date: 2018-03-21 Last modified: 2024-03-27 Method: ELECTRON MICROSCOPY (4.9 Å) Cite: Cryo-EM structure of human mTOR complex 2. Cell Res., 28, 2018
6CHZ	Estrogen Receptor Alpha Y537S bound to antagonist H3B-9224. Descriptor: 1,2-ETHANEDIOL, 4-[(2-{4-[(1E)-1-(1H-indazol-5-yl)-2-phenylbut-1-en-1-yl]phenoxy}ethyl)amino]-N,N-dimethylbutanamide, Estrogen receptor Authors: Larsen, N.A. Deposit date: 2018-02-23 Release date: 2018-03-21 Last modified: 2024-03-13 Method: X-RAY DIFFRACTION (1.68 Å) Cite: Discovery of Selective Estrogen Receptor Covalent Antagonists for the Treatment of ER alphaWTand ER alphaMUTBreast Cancer. Cancer Discov, 8, 2018
5Y3A	Crystal structure of Ragulator complex (p18 49-161) Descriptor: Ragulator complex protein LAMTOR1, Ragulator complex protein LAMTOR2, Ragulator complex protein LAMTOR3, ... Authors: Zhang, T, Ding, J. Deposit date: 2017-07-28 Release date: 2017-12-27 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (2.9 Å) Cite: Structural basis for Ragulator functioning as a scaffold in membrane-anchoring of Rag GTPases and mTORC1. Nat Commun, 8, 2017
5WBL	Crystal structure of the Arabidopsis thaliana Raptor in complex with the TOS peptide of human PRAS40 Descriptor: Proline-rich AKT1 substrate 1, Regulatory-associated protein of TOR 1 Authors: Pavletich, N.P, Jiang, X. Deposit date: 2017-06-29 Release date: 2017-12-20 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (3.35 Å) Cite: Mechanisms of mTORC1 activation by RHEB and inhibition by PRAS40. Nature, 552, 2017
5WBH	Structure of the FRB domain of mTOR bound to a substrate recruitment peptide of S6K1 Descriptor: Ribosomal protein S6 kinase beta-1, Serine/threonine-protein kinase mTOR Authors: Pavletich, N.P, Yang, H. Deposit date: 2017-06-29 Release date: 2017-12-20 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (1.75 Å) Cite: Mechanisms of mTORC1 activation by RHEB and inhibition by PRAS40. Nature, 552, 2017
6BCX	mTORC1 structure refined to 3.0 angstroms Descriptor: ADENOSINE-5'-TRIPHOSPHATE, Eukaryotic translation initiation factor 4E-binding protein 1, MAGNESIUM ION, ... Authors: Pavletich, N.P, Yang, H. Deposit date: 2017-10-20 Release date: 2017-12-20 Last modified: 2024-03-13 Method: ELECTRON MICROSCOPY (3.23 Å) Cite: Mechanisms of mTORC1 activation by RHEB and inhibition by PRAS40. Nature, 552, 2017
6BCU	Cryo-EM structure of the activated RHEB-mTORC1 refined to 3.4 angstrom Descriptor: ADENOSINE-5'-TRIPHOSPHATE, Eukaryotic translation initiation factor 4E-binding protein 1, GTP-binding protein Rheb, ... Authors: Pavletich, N.P, Yang, H. Deposit date: 2017-10-20 Release date: 2017-12-20 Last modified: 2024-03-13 Method: ELECTRON MICROSCOPY (3.8 Å) Cite: Mechanisms of mTORC1 activation by RHEB and inhibition by PRAS40. Nature, 552, 2017
5WBK	Crystal structure of the arabidopsis thaliana Raptor in complex with the TOS peptide of human S6K1 Descriptor: Regulatory-associated protein of TOR 1, Ribosomal protein S6 kinase beta-1 Authors: Pavletich, N.P, Jiang, X. Deposit date: 2017-06-29 Release date: 2017-12-20 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (3.11 Å) Cite: Mechanisms of mTORC1 activation by RHEB and inhibition by PRAS40. Nature, 552, 2017
5WBI	Crystal structure of the Arabidopsis thaliana Raptor Descriptor: Regulatory-associated protein of TOR 1 Authors: Pavletich, N.P, Jiang, X. Deposit date: 2017-06-29 Release date: 2017-12-20 Last modified: 2024-03-13 Method: X-RAY DIFFRACTION (3 Å) Cite: Mechanisms of mTORC1 activation by RHEB and inhibition by PRAS40. Nature, 552, 2017
5WBU	Crystal structure of mTOR(deltaN)-mLST8-PRAS40(alpha-helix & beta-strand) complex Descriptor: Proline-rich AKT1 substrate 1, Serine/threonine-protein kinase mTOR, Target of rapamycin complex subunit LST8 Authors: Pavletich, N.P, Yang, H. Deposit date: 2017-06-29 Release date: 2017-12-20 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (3.42 Å) Cite: Mechanisms of mTORC1 activation by RHEB and inhibition by PRAS40. Nature, 552, 2017
5WBJ	Crystal structure of the arabidopsis thaliana Raptor in complex with the TOS peptide of human 4EBP1 Descriptor: Eukaryotic translation initiation factor 4E-binding protein 1, Regulatory-associated protein of TOR 1 Authors: Pavletich, N.P, Jiang, X. Deposit date: 2017-06-29 Release date: 2017-12-20 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (3 Å) Cite: Mechanisms of mTORC1 activation by RHEB and inhibition by PRAS40. Nature, 552, 2017
5WBY	Crystal structure of mTOR(deltaN)-mLST8-PRAS40(beta-strand) complex Descriptor: Proline-rich AKT1 substrate 1, Serine/threonine-protein kinase mTOR, Target of rapamycin complex subunit LST8 Authors: Pavletich, N.P, Yang, H. Deposit date: 2017-06-29 Release date: 2017-12-20 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (3.1 Å) Cite: Mechanisms of mTORC1 activation by RHEB and inhibition by PRAS40. Nature, 552, 2017
5OBM	Crystal structure of Gentamicin bound to the yeast 80S ribosome Descriptor: (2R,3R,4R,5R)-2-((1S,2S,3R,4S,6R)-4,6-DIAMINO-3-((2R,3R,6S)-3-AMINO-6-(AMINOMETHYL)-TETRAHYDRO-2H-PYRAN-2-YLOXY)-2-HYDROXYCYCLOHEXYLOXY)-5-METHYL-4-(METHYLAMINO)-TETRAHYDRO-2H-PYRAN-3,5-DIOL, 18S ribosomal RNA, 25S ribosomal RNA, ... Authors: Prokhorova, I, Djumagulov, M, Urzhumtsev, A, Yusupov, M, Yusupova, G. Deposit date: 2017-06-28 Release date: 2017-12-13 Last modified: 2017-12-27 Method: X-RAY DIFFRACTION (3.4 Å) Cite: Aminoglycoside interactions and impacts on the eukaryotic ribosome. Proc. Natl. Acad. Sci. U.S.A., 114, 2017
5NDV	Crystal structure of Paromomycin bound to the yeast 80S ribosome Descriptor: 18S ribosomal RNA, 25S ribosomal RNA, 40S ribosomal protein S0-A, ... Authors: Prokhorova, I, Djumagulov, M, Urzhumtsev, A, Yusupov, M, Yusupova, G. Deposit date: 2017-03-09 Release date: 2017-12-13 Last modified: 2017-12-27 Method: X-RAY DIFFRACTION (3.3 Å) Cite: Aminoglycoside interactions and impacts on the eukaryotic ribosome. Proc. Natl. Acad. Sci. U.S.A., 114, 2017
5X6U	Crystal structure of human heteropentameric complex Descriptor: Ragulator complex protein LAMTOR1, Ragulator complex protein LAMTOR2, Ragulator complex protein LAMTOR3, ... Authors: Yonehara, R, Nada, S, Nakai, T, Nakai, M, Kitamura, A, Ogawa, A, Nakatsumi, H, Nakayama, K.I, Li, S, Standley, D.M, Yamashita, E, Nakagawa, A, Okada, M. Deposit date: 2017-02-23 Release date: 2017-12-06 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Structural basis for the assembly of the Ragulator-Rag GTPase complex. Nat Commun, 8, 2017
5X6V	Crystal structure of human heteroheptameric complex Descriptor: ACETATE ION, Ragulator complex protein LAMTOR1, Ragulator complex protein LAMTOR2, ... Authors: Yonehara, R, Nada, S, Nakai, T, Nakai, M, Kitamura, A, Ogawa, A, Nakatsumi, H, Nakayama, K.I, Li, S, Standley, D.M, Yamashita, E, Nakagawa, A, Okada, M. Deposit date: 2017-02-23 Release date: 2017-12-06 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (2.02 Å) Cite: Structural basis for the assembly of the Ragulator-Rag GTPase complex. Nat Commun, 8, 2017
5Y38	Crystal structure of C7orf59-HBXIP complex Descriptor: Ragulator complex protein LAMTOR4, Ragulator complex protein LAMTOR5, SULFATE ION Authors: Zhang, T, Ding, J. Deposit date: 2017-07-28 Release date: 2017-12-06 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (2.8 Å) Cite: Structural basis for Ragulator functioning as a scaffold in membrane-anchoring of Rag GTPases and mTORC1 Nat Commun, 8, 2017

<1234567891011>