5ZXB
Crystal structure of ACK1 with compound 10d
Summary for 5ZXB
Entry DOI | 10.2210/pdb5zxb/pdb |
Descriptor | Activated CDC42 kinase 1, N-{3-[7-{[6-(4-acetylpiperazin-1-yl)pyridin-3-yl]amino}-1-methyl-2-oxo-1,4-dihydropyrimido[4,5-d]pyrimidin-3(2H)-yl]-4-methylphenyl}-3-(trifluoromethyl)benzamide (3 entities in total) |
Functional Keywords | inhibitor, kinase, transferase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 64165.94 |
Authors | Hong, E.M.,Kim, H.L.,Sim, T.B. (deposition date: 2018-05-18, release date: 2018-09-26, Last modification date: 2024-03-27) |
Primary citation | Cho, H.,Shin, I.,Ju, E.,Choi, S.,Hur, W.,Kim, H.,Hong, E.,Kim, N.D.,Choi, H.G.,Gray, N.S.,Sim, T. First SAR Study for Overriding NRAS Mutant Driven Acute Myeloid Leukemia. J. Med. Chem., 61:8353-8373, 2018 Cited by PubMed: 30153003DOI: 10.1021/acs.jmedchem.8b00882 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.198 Å) |
Structure validation
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