7U8R
| Structure of porcine kidney V-ATPase with SidK, Rotary State 3 | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, ATPase H(+)-transporting lysosomal accessory protein 2, ATPase H+ transporting accessory protein 1, ... | 著者 | Tan, Y.Z, Keon, K.A. | 登録日 | 2022-03-09 | 公開日 | 2022-07-06 | 最終更新日 | 2024-02-14 | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | 主引用文献 | CryoEM of endogenous mammalian V-ATPase interacting with the TLDc protein mEAK-7. Life Sci Alliance, 5, 2022
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7U8O
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7U8Q
| Structure of porcine kidney V-ATPase with SidK, Rotary State 2 | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, ATPase H(+)-transporting lysosomal accessory protein 2, ATPase H+ transporting accessory protein 1, ... | 著者 | Tan, Y.Z, Keon, K.A. | 登録日 | 2022-03-09 | 公開日 | 2022-07-06 | 最終更新日 | 2024-02-14 | 実験手法 | ELECTRON MICROSCOPY (4.1 Å) | 主引用文献 | CryoEM of endogenous mammalian V-ATPase interacting with the TLDc protein mEAK-7. Life Sci Alliance, 5, 2022
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7UHY
| Human GATOR2 complex | 分子名称: | GATOR complex protein MIOS, GATOR complex protein WDR24, GATOR complex protein WDR59, ... | 著者 | Rogala, K.B, Valenstein, M.L, Lalgudi, P.V. | 登録日 | 2022-03-27 | 公開日 | 2022-07-20 | 最終更新日 | 2022-08-03 | 実験手法 | ELECTRON MICROSCOPY (3.66 Å) | 主引用文献 | Structure of the nutrient-sensing hub GATOR2. Nature, 607, 2022
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7Y62
| Crystal structure of human TFEB HLHLZ domain | 分子名称: | Transcription factor EB | 著者 | Yang, G, Li, P, Lin, Y, Liu, Z, Sun, H, Zhao, Z, Fang, P, Wang, J. | 登録日 | 2022-06-18 | 公開日 | 2023-03-22 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | A small-molecule drug inhibits autophagy gene expression through the central regulator TFEB. Proc.Natl.Acad.Sci.USA, 120, 2023
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4CKR
| Crystal structure of the human DDR1 kinase domain in complex with DDR1-IN-1 | 分子名称: | 1,2-ETHANEDIOL, 4-[(4-ethylpiperazin-1-yl)methyl]-n-{4-methyl-3-[(2-oxo-2,3-dihydro-1h-indol-5-yl)oxy]phenyl}-3-(trifluoromethyl)benzamide, EPITHELIAL DISCOIDIN DOMAIN-CONTAINING RECEPTOR 1 | 著者 | Canning, P, Elkins, J.M, Goubin, S, Mahajan, P, Krojer, T, Newman, J.A, Dixon-Clarke, S, Chaikuad, A, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Bullock, A. | 登録日 | 2014-01-07 | 公開日 | 2014-01-15 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Discovery of a Potent and Selective Ddr1 Receptor Tyrosine Kinase Inhibitor. Acs Chem.Biol., 8, 2013
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4EKL
| Akt1 with GDC0068 | 分子名称: | (2S)-2-(4-chlorophenyl)-1-{4-[(5R,7R)-7-hydroxy-5-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl]piperazin-1-yl}-3-(propan-2-ylamino)propan-1-one, RAC-alpha serine/threonine-protein kinase | 著者 | Wu, W.-I, Vigers, G.P.A, Morales, T.H, Brandhuber, B.J. | 登録日 | 2012-04-09 | 公開日 | 2012-05-23 | 最終更新日 | 2018-01-24 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | An ATP-Site On-Off Switch That Restricts Phosphatase Accessibility of Akt. Sci.Signal., 5, 2012
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4EKK
| Akt1 with AMP-PNP | 分子名称: | Glycogen synthase kinase-3 beta, MANGANESE (II) ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... | 著者 | Wu, W.-I, Vigers, G.P.A, Morales, T.H, Brandhuber, B.J. | 登録日 | 2012-04-09 | 公開日 | 2012-05-23 | 最終更新日 | 2018-01-24 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | An ATP-Site On-Off Switch That Restricts Phosphatase Accessibility of Akt. Sci.Signal., 5, 2012
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4FUL
| PI3 Kinase Gamma bound to a pyrmidine inhibitor | 分子名称: | 4-({4-[3-(piperidin-1-ylcarbonyl)phenyl]pyrimidin-2-yl}amino)benzenesulfonamide, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 著者 | Gopalsamy, A, Bennett, E.M, Shi, M, Zhang, W.G, Bard, J, Yu, K. | 登録日 | 2012-06-28 | 公開日 | 2012-10-17 | 最終更新日 | 2012-10-31 | 実験手法 | X-RAY DIFFRACTION (2.47 Å) | 主引用文献 | Identification of pyrimidine derivatives as hSMG-1 inhibitors. Bioorg.Med.Chem.Lett., 22, 2012
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4GV1
| PKB alpha in complex with AZD5363 | 分子名称: | 4-amino-N-[(1S)-1-(4-chlorophenyl)-3-hydroxypropyl]-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamide, GLYCEROL, RAC-alpha serine/threonine-protein kinase | 著者 | Addie, M, Ballard, P, Bird, G, Buttar, D, Currie, G, Davies, B, Debreczeni, J, Dry, H, Dudley, P, Greenwood, R, Hatter, G, Jestel, A, Johnson, P.D, Kettle, J.G, Lane, C, Lamont, G, Leach, A, Luke, R.W.A, Ogilvie, D, Page, K, Pass, M, Steinbacher, S, Steuber, H, Pearson, S, Ruston, L. | 登録日 | 2012-08-30 | 公開日 | 2013-02-27 | 最終更新日 | 2017-11-15 | 実験手法 | X-RAY DIFFRACTION (1.49 Å) | 主引用文献 | Discovery of 4-Amino-N-[(1S)-1-(4-chlorophenyl)-3-hydroxypropyl]-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamide (AZD5363), an Orally Bioavailable, Potent Inhibitor of Akt Kinases. J.Med.Chem., 56, 2013
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4KK1
| Crystal Structure of TSC1 core domain from S. pombe | 分子名称: | Tuberous sclerosis 1 protein homolog | 著者 | Sun, W, Zhu, Y, Wang, Z.Z, Zhong, Q, Gao, F, Lou, J.Z, Gong, W.M, Xu, W.Q. | 登録日 | 2013-05-05 | 公開日 | 2013-07-17 | 最終更新日 | 2013-07-31 | 実験手法 | X-RAY DIFFRACTION (3.3 Å) | 主引用文献 | Crystal structure of the yeast TSC1 core domain and implications for tuberous sclerosis pathological mutations. Nat Commun, 4, 2013
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4KK0
| Crystal Structure of TSC1 core domain from S. pombe | 分子名称: | Tuberous sclerosis 1 protein homolog | 著者 | Sun, W, Zhu, Y, Wang, Z.Z, Zhong, Q, Gao, F, Lou, J.Z, Gong, W.M, Xu, W.Q. | 登録日 | 2013-05-05 | 公開日 | 2013-07-17 | 最終更新日 | 2013-07-31 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | Crystal structure of the yeast TSC1 core domain and implications for tuberous sclerosis pathological mutations. Nat Commun, 4, 2013
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4L42
| Crystal structures of human p70S6K1-PIF | 分子名称: | 2-{[4-(5-ethylpyrimidin-4-yl)piperazin-1-yl]methyl}-5-(trifluoromethyl)-1H-benzimidazole, RPS6KB1 protein, SULFATE ION, ... | 著者 | Wang, J, Zhong, C, Ding, J. | 登録日 | 2013-06-07 | 公開日 | 2013-07-24 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Crystal structures of S6K1 provide insights into the regulation mechanism of S6K1 by the hydrophobic motif Biochem.J., 454, 2013
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4L44
| Crystal structures of human p70S6K1-T389A (form II) | 分子名称: | 2-{[4-(5-ethylpyrimidin-4-yl)piperazin-1-yl]methyl}-5-(trifluoromethyl)-1H-benzimidazole, RPS6KB1 protein, SULFATE ION, ... | 著者 | Wang, J, Zhong, C, Ding, J. | 登録日 | 2013-06-07 | 公開日 | 2013-07-24 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | Crystal structures of S6K1 provide insights into the regulation mechanism of S6K1 by the hydrophobic motif Biochem.J., 454, 2013
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4L46
| Crystal structures of human p70S6K1-WT | 分子名称: | 2-{[4-(5-ethylpyrimidin-4-yl)piperazin-1-yl]methyl}-5-(trifluoromethyl)-1H-benzimidazole, RPS6KB1 protein, SULFATE ION, ... | 著者 | Wang, J, Zhong, C, Ding, J. | 登録日 | 2013-06-07 | 公開日 | 2013-07-24 | 最終更新日 | 2017-11-15 | 実験手法 | X-RAY DIFFRACTION (3.01 Å) | 主引用文献 | Crystal structures of S6K1 provide insights into the regulation mechanism of S6K1 by the hydrophobic motif Biochem.J., 454, 2013
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4L45
| Crystal structures of human p70S6K1-T389E | 分子名称: | 2-{[4-(5-ethylpyrimidin-4-yl)piperazin-1-yl]methyl}-5-(trifluoromethyl)-1H-benzimidazole, RPS6KB1 protein | 著者 | Wang, J, Zhong, C, Ding, J. | 登録日 | 2013-06-07 | 公開日 | 2013-07-24 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | Crystal structures of S6K1 provide insights into the regulation mechanism of S6K1 by the hydrophobic motif Biochem.J., 454, 2013
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4L43
| Crystal structures of human p70S6K1-T389A (form I) | 分子名称: | 2-{[4-(5-ethylpyrimidin-4-yl)piperazin-1-yl]methyl}-5-(trifluoromethyl)-1H-benzimidazole, RPS6KB1 protein | 著者 | Wang, J, Zhong, C, Ding, J. | 登録日 | 2013-06-07 | 公開日 | 2013-07-24 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | Crystal structures of S6K1 provide insights into the regulation mechanism of S6K1 by the hydrophobic motif Biochem.J., 454, 2013
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5ZXB
| Crystal structure of ACK1 with compound 10d | 分子名称: | Activated CDC42 kinase 1, N-{3-[7-{[6-(4-acetylpiperazin-1-yl)pyridin-3-yl]amino}-1-methyl-2-oxo-1,4-dihydropyrimido[4,5-d]pyrimidin-3(2H)-yl]-4-methylphenyl}-3-(trifluoromethyl)benzamide | 著者 | Hong, E.M, Kim, H.L, Sim, T.B. | 登録日 | 2018-05-18 | 公開日 | 2018-09-26 | 最終更新日 | 2024-03-27 | 実験手法 | X-RAY DIFFRACTION (2.198 Å) | 主引用文献 | First SAR Study for Overriding NRAS Mutant Driven Acute Myeloid Leukemia. J. Med. Chem., 61, 2018
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4N1Z
| Crystal Structure of Human Farnesyl Diphosphate Synthase in Complex with BPH-1222 | 分子名称: | Farnesyl pyrophosphate synthase, MAGNESIUM ION, PHOSPHATE ION, ... | 著者 | Liu, Y.L, Xia, Y, Zhang, Y, Verma, I, Oldfield, E. | 登録日 | 2013-10-04 | 公開日 | 2014-12-10 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.35 Å) | 主引用文献 | A combination therapy for KRAS-driven lung adenocarcinomas using lipophilic bisphosphonates and rapamycin. Sci Transl Med, 6, 2014
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6BUU
| Crystal structure of AKT1 (aa 144-480) with a bisubstrate | 分子名称: | GLY-ARG-PRO-ARG-THR-THR-ZXW-PHE-ALA-GLU, MANGANESE (II) ION, RAC-alpha serine/threonine-protein kinase, ... | 著者 | Chu, N, Gabelli, S.B, Cole, P.A. | 登録日 | 2017-12-11 | 公開日 | 2018-08-22 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Akt Kinase Activation Mechanisms Revealed Using Protein Semisynthesis. Cell, 174, 2018
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3M93
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3M94
| Complex crystal structure of Ascaris suum eIF4E-3 with m2,2,7G cap | 分子名称: | ACETYL GROUP, Eukaryotic translation initiation factor 4E-binding protein 1, N,N,7-trimethylguanosine 5'-(trihydrogen diphosphate), ... | 著者 | Liu, W, Berkeley Structural Genomics Center (BSGC) | 登録日 | 2010-03-19 | 公開日 | 2011-07-20 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | 主引用文献 | Structural basis for nematode eIF4E binding an m2,2,7G-Cap and its implications for translation initiation. Nucleic Acids Res., 39, 2011
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3MVH
| Crystal structure of Akt-1-inhibitor complexes | 分子名称: | GSK3-beta peptide, MANGANESE (II) ION, N-{[(3S)-3-amino-1-(5-ethyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)pyrrolidin-3-yl]methyl}-2,4-difluorobenzamide, ... | 著者 | Pandit, J. | 登録日 | 2010-05-04 | 公開日 | 2010-06-02 | 最終更新日 | 2021-10-06 | 実験手法 | X-RAY DIFFRACTION (2.01 Å) | 主引用文献 | Design of selective, ATP-competitive inhibitors of Akt. J.Med.Chem., 53, 2010
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3MV5
| Crystal structure of Akt-1-inhibitor complexes | 分子名称: | (3R)-1-(5-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)pyrrolidin-3-amine, GSK3-beta peptide, MANGANESE (II) ION, ... | 著者 | Pandit, J. | 登録日 | 2010-05-03 | 公開日 | 2010-06-02 | 最終更新日 | 2021-10-06 | 実験手法 | X-RAY DIFFRACTION (2.47 Å) | 主引用文献 | Design of selective, ATP-competitive inhibitors of Akt. J.Med.Chem., 53, 2010
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3OCB
| Akt1 kinase domain with pyrrolopyrimidine inhibitor | 分子名称: | (2S)-2-(4-chlorobenzyl)-3-oxo-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperazin-1-yl]propan-1-amine, GSK 3 beta peptide, v-akt murine thymoma viral oncogene homolog 1 (AKT1) | 著者 | Morales, T.H, Vigers, G.P.A, Brandhuber, B.J. | 登録日 | 2010-08-09 | 公開日 | 2010-09-15 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Discovery of pyrrolopyrimidine inhibitors of Akt. Bioorg.Med.Chem.Lett., 20, 2010
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