4CKR

Crystal structure of the human DDR1 kinase domain in complex with DDR1-IN-1

Replaces:  4BKI

Summary for 4CKR

• Entry DOI: 10.2210/pdb4ckr/pdb
• Descriptor: EPITHELIAL DISCOIDIN DOMAIN-CONTAINING RECEPTOR 1, 4-[(4-ethylpiperazin-1-yl)methyl]-n-{4-methyl-3-[(2-oxo-2,3-dihydro-1h-indol-5-yl)oxy]phenyl}-3-(trifluoromethyl)benzamide, 1,2-ETHANEDIOL, ... (4 entities in total)
• Functional Keywords: transferase, collagen, discoidin domain
• Biological source: HOMO SAPIENS (HUMAN)
• Cellular location: Isoform 1: Cell membrane; Single-pass type I membrane protein. Isoform 2: Cell membrane; Single-pass type I membrane protein. Isoform 3: Secreted . Isoform 4: Cell membrane; Single-pass type I membrane protein: Q08345
• Total number of polymer chains: 1
• Total formula weight: 36617.02

Authors

Canning, P.,Elkins, J.M.,Goubin, S.,Mahajan, P.,Krojer, T.,Newman, J.A.,Dixon-Clarke, S.,Chaikuad, A.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Bullock, A. (deposition date: 2014-01-07, release date: 2014-01-15, Last modification date: 2023-12-20)

• Primary citation: Kim, H.,Tan, L.,Weisberg, E.L.,Liu, F.,Canning, P.,Choi, H.G.,Ezell, S.A.,Wu, H.,Zhao, Z.,Wang, J.,Mandinova, A.,Griffin, J.D.,Bullock, A.N.,Liu, Q.,Lee, S.W.,Gray, N.S.; Discovery of a Potent and Selective Ddr1 Receptor Tyrosine Kinase Inhibitor.; Acs Chem.Biol., 8:2145-, 2013; PubMed: 23899692; DOI: 10.1021/CB400430T

Experimental method

X-RAY DIFFRACTION (2.2 Å)