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4CKR

Crystal structure of the human DDR1 kinase domain in complex with DDR1-IN-1

Replaces:  4BKI
Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A
(A)
EPITHELIAL DISCOIDIN DOMAIN-CONTAINING RECEPTOR 1polymer31535754.11UniProt (Q08345)
Pfam (PF07714)
HOMO SAPIENS (HUMAN)EPITHELIAL DISCOIDIN DOMAIN RECEPTOR 1, CD167 ANTIGEN-LIKE FAMILY MEMBER A, CELL ADHESION KINASE, DISCOIDIN RECEPTOR TYROSINE KINASE, HGK2, MAMMARY CARCINOMA KINASE 10, MCK-10, PROTEIN-TYROSINE KINASE 3A, PROTEIN-TYROSINE KINASE RTK-6, TRK E, TYROSINE KINASE DDR, TYROSINE-PROTEIN KINASE CAK, CD167A
2B
(A)
4-[(4-ethylpiperazin-1-yl)methyl]-n-{4-methyl-3-[(2-oxo-2,3-dihydro-1h-indol-5-yl)oxy]phenyl}-3-(trifluoromethyl)benzamidenon-polymer552.61Chemie (DI1)
3C, D, E, F, G
(A)
1,2-ETHANEDIOLnon-polymer62.15Chemie (EDO)
4H
(A)
waterwater18.038Chemie (HOH)
Sequence modifications
A: 601 - 913 (UniProt: Q08345)
PDBExternal DatabaseDetails
Ser 599-expression tag
Met 600-expression tag
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains1
Total formula weight35754.1
Non-Polymers*Number of molecules6
Total formula weight862.9
All*Total formula weight36617.0
*Water molecules are not included.

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PDB entries from 2025-06-18

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