PDB: 5594 resultsInfo pagesStatus searchChemie searchBIRD

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6IEV	Crystal structure of a designed protein Descriptor: Designed protein Authors: Han, M, Liao, S, Chen, Q, Liu, H. Deposit date: 2018-09-17 Release date: 2019-09-18 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (2.25 Å) Cite: Selection and analyses of variants of a designed protein suggest importance of hydrophobicity of partially buried sidechains for protein stability at high temperatures. Protein Sci., 28, 2019
5J0I	De novo design of protein homo-oligomers with modular hydrogen bond network-mediated specificity Descriptor: Designed protein 2L6HC3_12 Authors: Sankaran, B, Zwart, P.H, Pereira, J.H, Baker, D, Boyken, S, Chen, Z, Groves, B, Langan, R.A, Oberdorfer, G, Ford, A, Gilmore, J, Xu, C, DiMaio, F, Seelig, G. Deposit date: 2016-03-28 Release date: 2016-05-25 Last modified: 2024-03-06 Method: X-RAY DIFFRACTION (2.202 Å) Cite: De novo design of protein homo-oligomers with modular hydrogen-bond network-mediated specificity. Science, 352, 2016
5IZS	De novo design of protein homo-oligomers with modular hydrogen bond network-mediated specificity Descriptor: Designed protein 5L6HC3_1 Authors: Sankaran, B, Zwart, P.H, Pereira, J.H, Baker, D, Boyken, S, Chen, Z, Oberdorfer, G. Deposit date: 2016-03-25 Release date: 2016-05-25 Last modified: 2024-03-06 Method: X-RAY DIFFRACTION (2.36 Å) Cite: De novo design of protein homo-oligomers with modular hydrogen-bond network-mediated specificity. Science, 352, 2016
5J0K	De novo design of protein homo-oligomers with modular hydrogen bond network-mediated specificity Descriptor: designed protein 2L4HC2_23 Authors: Sankaran, B, Zwart, P.H, Pereira, J.H, Baker, D, Boyken, S, Chen, Z, Groves, B, Langan, R.A, Oberdorfer, G, Ford, A, Gilmore, J, Xu, C, DiMaio, F, Seelig, G. Deposit date: 2016-03-28 Release date: 2016-05-25 Last modified: 2024-03-06 Method: X-RAY DIFFRACTION (1.54 Å) Cite: De novo design of protein homo-oligomers with modular hydrogen-bond network-mediated specificity. Science, 352, 2016
5J0L	De novo design of protein homo-oligomers with modular hydrogen bond network-mediated specificity Descriptor: designed protein 3L6HC2_2 Authors: Sankaran, B, Zwart, P.H, Pereira, J.H, Baker, D, Boyken, S, Chen, Z, Groves, B, Langan, R.A, Oberdorfer, G, Ford, A, Gilmore, J, Xu, C, DiMaio, F, Seelig, G. Deposit date: 2016-03-28 Release date: 2016-07-06 Last modified: 2024-03-06 Method: X-RAY DIFFRACTION (2.63 Å) Cite: De novo design of protein homo-oligomers with modular hydrogen-bond network-mediated specificity. Science, 352, 2016
5J0J	De novo design of protein homo-oligomers with modular hydrogen bond network-mediated specificity Descriptor: designed protein 2L6HC3_6 Authors: Sankaran, B, Zwart, P.H, Pereira, J.H, Baker, D, Boyken, S, Chen, Z, Groves, B, Langan, R.A, Oberdorfer, G, Ford, A, Gilmore, J, Xu, C, DiMaio, F, Seelig, G. Deposit date: 2016-03-28 Release date: 2016-05-25 Last modified: 2024-03-06 Method: X-RAY DIFFRACTION (2.256 Å) Cite: De novo design of protein homo-oligomers with modular hydrogen-bond network-mediated specificity. Science, 352, 2016
6WRX	Crystal structure of computationally designed protein 2DS25.1 in complex with the human Transferrin receptor ectodomain Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... Authors: Abraham, J, Coscia, A, Olal, D, Sahtoe, D.D, Baker, D, Clark, L. Deposit date: 2020-04-30 Release date: 2021-04-28 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (3.07 Å) Cite: Transferrin receptor targeting by de novo sheet extension. Proc.Natl.Acad.Sci.USA, 118, 2021
6WRV	Crystal structure of computationally designed protein 3DS18 in complex with the human Transferrin receptor ectodomain Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, Computationally designed protein 3DS18, ... Authors: Abraham, J, Baker, D, Sahtoe, D.D, Coscia, A, Clark, L, Olal, D. Deposit date: 2020-04-30 Release date: 2021-04-28 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (2.47 Å) Cite: Transferrin receptor targeting by de novo sheet extension. Proc.Natl.Acad.Sci.USA, 118, 2021
6WRW	Crystal structure of computationally designed protein 2DS25.5 in complex with the human Transferrin receptor ectodomain Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, Computationally designed protein 2DS25.5, ... Authors: Abraham, J, Coscia, A, Olal, D, Sahtoe, D.D, Baker, D, Clark, L. Deposit date: 2020-04-30 Release date: 2021-04-28 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (2.84 Å) Cite: Transferrin receptor targeting by de novo sheet extension. Proc.Natl.Acad.Sci.USA, 118, 2021
8DZ8	Neoleukin 4, a de novo designed IL-4 mimetic Descriptor: neoleukin-4 Authors: Jude, K.M, Spangler, J.B, Garcia, K.C. Deposit date: 2022-08-06 Release date: 2023-03-29 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (2.972 Å) Cite: Design of cell-type-specific hyperstable IL-4 mimetics via modular de novo scaffolds. Nat.Chem.Biol., 19, 2023
8JU8	de novo designed protein Descriptor: de novo designed protein Authors: Zhang, L. Deposit date: 2023-06-25 Release date: 2023-07-26 Method: X-RAY DIFFRACTION (1.85 Å) Cite: de novo designed Rossmann fold protein To Be Published
5TPH	Crystal structure of a de novo designed protein homodimer with curved beta-sheet Descriptor: CHLORIDE ION, DI(HYDROXYETHYL)ETHER, de novo NTF2 homodimer Authors: Basanta, B, Marcos, E, Oberdorfer, G, Chidyausiku, T.M, Sankaran, B, Baker, D. Deposit date: 2016-10-20 Release date: 2017-01-25 Last modified: 2024-03-06 Method: X-RAY DIFFRACTION (2.47 Å) Cite: Principles for designing proteins with cavities formed by curved beta sheets. Science, 355, 2017
5U35	Crystal structure of a de novo designed protein with curved beta-sheet Descriptor: 1-(2-METHOXY-ETHOXY)-2-{2-[2-(2-METHOXY-ETHOXY]-ETHOXY}-ETHANE, 2-METHOXYETHANOL, CHLORIDE ION, ... Authors: Oberdorfer, G, Marcos, E, Basanta, B, Chidyausiku, T.M, Sankaran, B, Zwart, P.H, Baker, D. Deposit date: 2016-12-01 Release date: 2017-01-25 Last modified: 2024-03-06 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Principles for designing proteins with cavities formed by curved beta sheets. Science, 355, 2017
5WLL	De Novo Design of Polynuclear Transition Metal Clusters in Helix Bundles-4DH1 Descriptor: GLYCEROL, Helical Bundle 4DH1, ZINC ION Authors: Zhang, S.-Q, Liu, L, DeGrado, W.F. Deposit date: 2017-07-27 Release date: 2018-01-03 Last modified: 2020-01-01 Method: X-RAY DIFFRACTION (1.9 Å) Cite: De Novo Design of Tetranuclear Transition Metal Clusters Stabilized by Hydrogen-Bonded Networks in Helical Bundles. J. Am. Chem. Soc., 140, 2018
5WLM	De Novo Design of Polynuclear Transition Metal Clusters in Helix Bundles-4DH2 Descriptor: Helical Bundle 4DH2, ZINC ION Authors: Zhang, S.-Q, Liu, L, DeGrado, W.F. Deposit date: 2017-07-27 Release date: 2018-01-03 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (1.95 Å) Cite: De Novo Design of Tetranuclear Transition Metal Clusters Stabilized by Hydrogen-Bonded Networks in Helical Bundles. J. Am. Chem. Soc., 140, 2018
5WLK	De Novo Design of Polynuclear Transition Metal Clusters in Helix Bundles-4EH2 Descriptor: Helical Bundle 4EH2, ZINC ION Authors: Zhang, S.-Q, Liu, L, DeGrado, W.F. Deposit date: 2017-07-27 Release date: 2018-01-03 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (1.8 Å) Cite: De Novo Design of Tetranuclear Transition Metal Clusters Stabilized by Hydrogen-Bonded Networks in Helical Bundles. J. Am. Chem. Soc., 140, 2018
1VJQ	Designed protein based on backbone conformation of procarboxypeptidase-A (1AYE) with sidechains chosen for maximal predicted stability. Descriptor: designed protein Authors: Merritt, E.A, Baker, D, Structural Genomics of Pathogenic Protozoa Consortium (SGPP) Deposit date: 2004-03-19 Release date: 2004-03-30 Last modified: 2023-12-27 Method: X-RAY DIFFRACTION (2.098 Å) Cite: Designed protein based on backbone conformation of procarboxypeptidase-A (1AYE) with sidechains chosen for maximal predicted stability. To be Published
8H7C	Crystal structure of a de novo enzyme, ferric enterobactin esterase Syn-F4 (K4T) - Pt derivative Descriptor: ACETATE ION, CHLORIDE ION, De novo ferric enterobactin esterase Syn-F4, ... Authors: Kurihara, K, Umezawa, K, Donnelly, A.E, Hecht, M.H, Arai, R. Deposit date: 2022-10-19 Release date: 2023-09-20 Method: X-RAY DIFFRACTION (2.15 Å) Cite: Crystal structure and activity of a de novo enzyme, ferric enterobactin esterase Syn-F4. Proc.Natl.Acad.Sci.USA, 120, 2023
8H7E	Crystal structure of a de novo enzyme, ferric enterobactin esterase Syn-F4 (K4T) at 2.0 angstrom resolution Descriptor: ACETATE ION, De novo ferric enterobactin esterase Syn-F4 Authors: Kurihara, K, Umezawa, K, Donnelly, A.E, Hecht, M.H, Arai, R. Deposit date: 2022-10-19 Release date: 2023-09-20 Method: X-RAY DIFFRACTION (2 Å) Cite: Crystal structure and activity of a de novo enzyme, ferric enterobactin esterase Syn-F4. Proc.Natl.Acad.Sci.USA, 120, 2023
8H7D	Crystal structure of a de novo enzyme, ferric enterobactin esterase Syn-F4 (K4T) Descriptor: ACETATE ION, De novo ferric enterobactin esterase Syn-F4 Authors: Kurihara, K, Umezawa, K, Donnelly, A.E, Hecht, M.H, Arai, R. Deposit date: 2022-10-19 Release date: 2023-09-20 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Crystal structure and activity of a de novo enzyme, ferric enterobactin esterase Syn-F4. Proc.Natl.Acad.Sci.USA, 120, 2023
5JG9	Crystal structure of the de novo mini protein gEHEE_06 Descriptor: CHLORIDE ION, GLYCEROL, de novo design, ... Authors: Rupert, P.B, Johnsen, W.A. Deposit date: 2016-04-19 Release date: 2016-09-28 Last modified: 2016-11-02 Method: X-RAY DIFFRACTION (2.09 Å) Cite: Accurate de novo design of hyperstable constrained peptides. Nature, 538, 2016
8JPA	De novo design cavitated protein without predefined topology Descriptor: De novo design cavitated protein Authors: Hu, X, Xu, Y. Deposit date: 2023-06-11 Release date: 2023-06-28 Method: X-RAY DIFFRACTION (2.3 Å) Cite: De novo design cavitated protein without predefined topology To Be Published
6VTW	De novo protein design enables the precise induction of RSV-neutralizing antibodies Descriptor: 101F Fab Heavy Chain, 101F Fab Light Chain, S4_2.45 Authors: Jardetzky, T, Correia, B. Deposit date: 2020-02-13 Release date: 2020-04-15 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (2.6 Å) Cite: De novo protein design enables the precise induction of RSV-neutralizing antibodies. Science, 368, 2020
2A3D	SOLUTION STRUCTURE OF A DE NOVO DESIGNED SINGLE CHAIN THREE-HELIX BUNDLE (A3D) Descriptor: PROTEIN (DE NOVO THREE-HELIX BUNDLE) Authors: Walsh, S.T.R, Cheng, H, Bryson, J.W, Roder, H, Degrado, W.F. Deposit date: 1999-04-01 Release date: 1999-05-05 Last modified: 2023-12-27 Method: SOLUTION NMR Cite: Solution structure and dynamics of a de novo designed three-helix bundle protein. Proc.Natl.Acad.Sci.USA, 96, 1999
6YQX	Crystal structure of DeNovoTIM13, a de novo designed TIM barrel Descriptor: CHLORIDE ION, GLYCEROL, de novo designed TIM barrel DeNovoTIM13 Authors: Romero-Romero, S, Kordes, S, Shanmugaratnam, S, Fernandez-Velasco, D.A, Hocker, B. Deposit date: 2020-04-18 Release date: 2021-07-21 Last modified: 2024-05-01 Method: X-RAY DIFFRACTION (1.638 Å) Cite: The Stability Landscape of de novo TIM Barrels Explored by a Modular Design Approach. J.Mol.Biol., 433, 2021

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