4ENO
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![BU of 4eno by Molmil](/molmil-images/mine/4eno) | Crystal structure of oxidized human nm23-H1 | Descriptor: | Nucleoside diphosphate kinase A, PHOSPHATE ION | Authors: | Kim, M.-S, Shin, D.-H. | Deposit date: | 2012-04-13 | Release date: | 2013-03-27 | Last modified: | 2019-12-25 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Structure of Nm23-H1 under oxidative conditions. Acta Crystallogr.,Sect.D, 69, 2013
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5VFZ
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![BU of 5vfz by Molmil](/molmil-images/mine/5vfz) | |
3U85
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![BU of 3u85 by Molmil](/molmil-images/mine/3u85) | |
6Q3F
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![BU of 6q3f by Molmil](/molmil-images/mine/6q3f) | CDK2 in complex with FragLite2 | Descriptor: | 4-bromanylpyridin-2-amine, Cyclin-dependent kinase 2 | Authors: | Wood, D.J, Martin, M.P, Noble, M.E.M. | Deposit date: | 2018-12-04 | Release date: | 2019-03-20 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.18 Å) | Cite: | FragLites-Minimal, Halogenated Fragments Displaying Pharmacophore Doublets. An Efficient Approach to Druggability Assessment and Hit Generation. J.Med.Chem., 62, 2019
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3PS0
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![BU of 3ps0 by Molmil](/molmil-images/mine/3ps0) | The structure of the CRISPR-associated protein, csa2, from Sulfolobus solfataricus | Descriptor: | CRISPR-Associated protein, CSA2 | Authors: | Lintner, N.G, Sdano, M, Young, M.J, Lawrence, C.M. | Deposit date: | 2010-11-30 | Release date: | 2011-04-20 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structural and functional characterization of an archaeal clustered regularly interspaced short palindromic repeat (CRISPR)-associated complex for antiviral defense (CASCADE). J.Biol.Chem., 286, 2011
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5Z7H
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![BU of 5z7h by Molmil](/molmil-images/mine/5z7h) | |
3U86
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3U88
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![BU of 3u88 by Molmil](/molmil-images/mine/3u88) | Crystal structure of human menin in complex with MLL1 and LEDGF | Descriptor: | (4beta,8alpha,9R)-6'-methoxy-10,11-dihydrocinchonan-9-ol, CHOLIC ACID, GLYOXYLIC ACID, ... | Authors: | Huang, J, Wan, B, Lei, M. | Deposit date: | 2011-10-16 | Release date: | 2012-02-15 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | The same pocket in menin binds both MLL and JUND but has opposite effects on transcription. Nature, 482, 2012
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2KNH
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![BU of 2knh by Molmil](/molmil-images/mine/2knh) | The Solution structure of the eTAFH domain of AML1-ETO complexed with HEB peptide | Descriptor: | Protein CBFA2T1, Transcription factor 12 | Authors: | Park, S, Cierpicki, T, Tonelli, M, Bushweller, J.H. | Deposit date: | 2009-08-25 | Release date: | 2009-10-06 | Last modified: | 2024-05-01 | Method: | SOLUTION NMR | Cite: | Structure of the AML1-ETO eTAFH domain-HEB peptide complex and its contribution to AML1-ETO activity. Blood, 113, 2009
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4PVU
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![BU of 4pvu by Molmil](/molmil-images/mine/4pvu) | Crystal structure of the complex between PPARgamma-LBD and the R enantiomer of Mbx-102 (Metaglidasen) | Descriptor: | (2R)-(4-chlorophenyl)[3-(trifluoromethyl)phenoxy]ethanoic acid, Peroxisome proliferator-activated receptor gamma | Authors: | Pochetti, G, Montanari, R, Capelli, D, Loiodice, F, Laghezza, A, Piemontese, L, Lavecchia, A. | Deposit date: | 2014-03-18 | Release date: | 2015-02-11 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | On the metabolically active form of metaglidasen: improved synthesis and investigation of its peculiar activity on peroxisome proliferator-activated receptors and skeletal muscles. Chemmedchem, 10, 2015
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4D5C
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3U84
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![BU of 3u84 by Molmil](/molmil-images/mine/3u84) | Crystal Structure of Human Menin | Descriptor: | Menin | Authors: | Huang, J, Wan, B, Lei, M. | Deposit date: | 2011-10-15 | Release date: | 2012-02-15 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | The same pocket in menin binds both MLL and JUND but has opposite effects on transcription. Nature, 482, 2012
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5LJ5
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![BU of 5lj5 by Molmil](/molmil-images/mine/5lj5) | Overall structure of the yeast spliceosome immediately after branching. | Descriptor: | CWC15, CWC22, Exon 1 (5' exon) of UBC4 pre-mRNA, ... | Authors: | Galej, W.P, Wilkinson, M.F, Fica, S.M, Oubridge, C, Newman, A.J, Nagai, K. | Deposit date: | 2016-07-17 | Release date: | 2016-08-31 | Last modified: | 2019-12-11 | Method: | ELECTRON MICROSCOPY (3.8 Å) | Cite: | Cryo-EM structure of the spliceosome immediately after branching. Nature, 537, 2016
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2DG7
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![BU of 2dg7 by Molmil](/molmil-images/mine/2dg7) | Crystal structure of the putative transcriptional regulator SCO0337 from Streptomyces coelicolor A3(2) | Descriptor: | putative transcriptional regulator | Authors: | Hayashi, T, Tanaka, Y, Sakai, N, Yao, M, Tamura, T, Tanaka, I. | Deposit date: | 2006-03-08 | Release date: | 2007-03-13 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Crystal structure of the putative transcriptional regulator SCO0337 from Streptomyces coelicolor A3(2) To be Published
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7QPD
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![BU of 7qpd by Molmil](/molmil-images/mine/7qpd) | Structure of the human MHC I peptide-loading complex editing module | Descriptor: | Beta-2-microglobulin, Calreticulin, HLA class I histocompatibility antigen, ... | Authors: | Domnick, A, Susac, L, Trowitzsch, S, Thomas, C, Tampe, R. | Deposit date: | 2022-01-03 | Release date: | 2022-07-20 | Last modified: | 2022-08-24 | Method: | ELECTRON MICROSCOPY (3.73 Å) | Cite: | Molecular basis of MHC I quality control in the peptide loading complex. Nat Commun, 13, 2022
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2DJN
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![BU of 2djn by Molmil](/molmil-images/mine/2djn) | The solution structure of the homeobox domain of human Homeobox protein DLX-5 | Descriptor: | Homeobox protein DLX-5 | Authors: | Sasagawa, A, Ohnishi, S, Tochio, N, Saito, K, Koshiba, S, Inoue, M, Kigawa, T, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | Deposit date: | 2006-04-05 | Release date: | 2006-10-05 | Last modified: | 2024-05-29 | Method: | SOLUTION NMR | Cite: | The solution structure of the homeobox domain of human Homeobox protein DLX-5 To be Published
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7QB2
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![BU of 7qb2 by Molmil](/molmil-images/mine/7qb2) | Pim1 in complex with (E)-4-((6-amino-1-methyl-2-oxoindolin-3-ylidene)methyl)benzoic acid and Pimtide | Descriptor: | 4-[(E)-(6-azanyl-1-methyl-2-oxidanylidene-indol-3-ylidene)methyl]benzoic acid, GLYCEROL, Pimtide, ... | Authors: | Hochban, P.M.M, Heine, A, Diederich, W.E. | Deposit date: | 2021-11-18 | Release date: | 2022-11-30 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.53 Å) | Cite: | Pose, duplicate, then elaborate: Steps towards increased affinity for inhibitors targeting the specificity surface of the Pim-1 kinase. Eur.J.Med.Chem., 245, 2023
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4XC5
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![BU of 4xc5 by Molmil](/molmil-images/mine/4xc5) | CRYSTAL STRUCTURE OF THE T1L REOVIRUS ATTACHMENT PROTEIN SIGMA1 | Descriptor: | ACETATE ION, CHLORIDE ION, GLYCEROL, ... | Authors: | Reiss, K, Stehle, T. | Deposit date: | 2014-12-17 | Release date: | 2015-04-01 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Structure of Serotype 1 Reovirus Attachment Protein sigma 1 in Complex with Junctional Adhesion Molecule A Reveals a Conserved Serotype-Independent Binding Epitope. J.Virol., 89, 2015
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7QFM
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![BU of 7qfm by Molmil](/molmil-images/mine/7qfm) | Pim1 in complex with (E)-4-((2-oxoindolin-3-ylidene)methyl)benzoic acid and Pimtide | Descriptor: | 4-[(~{E})-(2-oxidanylidene-1~{H}-indol-3-ylidene)methyl]benzoic acid, GLYCEROL, Pimtide, ... | Authors: | Hochban, P.M.M, Heine, A, Diederich, W.E. | Deposit date: | 2021-12-06 | Release date: | 2022-12-21 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Pose, duplicate, then elaborate: Steps towards increased affinity for inhibitors targeting the specificity surface of the Pim-1 kinase. Eur.J.Med.Chem., 245, 2023
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4XHK
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![BU of 4xhk by Molmil](/molmil-images/mine/4xhk) | PIM1 kinase in complex with Compound 1s | Descriptor: | 2-(2,6-difluorophenyl)-N-{4-[(3S)-pyrrolidin-3-yloxy]pyridin-3-yl}-1,3-thiazole-4-carboxamide, Serine/threonine-protein kinase pim-1 | Authors: | Marcotte, D.J, Silvian, L.F. | Deposit date: | 2015-01-05 | Release date: | 2015-02-11 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Structure-based design of low-nanomolar PIM kinase inhibitors. Bioorg.Med.Chem.Lett., 25, 2015
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5MBR
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![BU of 5mbr by Molmil](/molmil-images/mine/5mbr) | |
5MCR
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![BU of 5mcr by Molmil](/molmil-images/mine/5mcr) | Quadruplex with flipped tetrad formed by an artificial sequence | Descriptor: | Artificial quadruplex with propeller, diagonal and lateral loop | Authors: | Dickerhoff, J, Haase, L, Langel, W, Weisz, K. | Deposit date: | 2016-11-10 | Release date: | 2017-04-19 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Tracing Effects of Fluorine Substitutions on G-Quadruplex Conformational Changes. ACS Chem. Biol., 12, 2017
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7A4Y
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![BU of 7a4y by Molmil](/molmil-images/mine/7a4y) | Crystal structure of the P5P6 coiled-coil in complex with nanobody Nb34. | Descriptor: | 1,2-ETHANEDIOL, Coiled-coil P5 peptide, Coiled-coil P6 peptide, ... | Authors: | Hadzi, S. | Deposit date: | 2020-08-20 | Release date: | 2021-05-05 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (2.157 Å) | Cite: | A nanobody toolbox targeting dimeric coiled-coil modules for functionalization of designed protein origami structures. Proc.Natl.Acad.Sci.USA, 118, 2021
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7A4T
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![BU of 7a4t by Molmil](/molmil-images/mine/7a4t) | Crystal structure of the GCN coiled-coil in complex with nanobody Nb39 | Descriptor: | 1,2-ETHANEDIOL, ACETYL GROUP, GCN4 isoform 1, ... | Authors: | Hadzi, S. | Deposit date: | 2020-08-20 | Release date: | 2021-05-05 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (2.124 Å) | Cite: | A nanobody toolbox targeting dimeric coiled-coil modules for functionalization of designed protein origami structures. Proc.Natl.Acad.Sci.USA, 118, 2021
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4XH6
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![BU of 4xh6 by Molmil](/molmil-images/mine/4xh6) | Crystal structure of proto-oncogene kinase Pim1 bound to hispidulin | Descriptor: | 5,7-dihydroxy-2-(4-hydroxyphenyl)-6-methoxy-4H-chromen-4-one, Serine/threonine-protein kinase pim-1 | Authors: | Su, M.-Y, Chang, C.-I. | Deposit date: | 2015-01-05 | Release date: | 2015-08-26 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.04 Å) | Cite: | Total Synthesis of Hispidulin and the Structural Basis for Its Inhibition of Proto-oncogene Kinase Pim-1 J.Nat.Prod., 78, 2015
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