7QB2

Pim1 in complex with (E)-4-((6-amino-1-methyl-2-oxoindolin-3-ylidene)methyl)benzoic acid and Pimtide

Summary for 7QB2

Entry DOI	10.2210/pdb7qb2/pdb
Descriptor	Serine/threonine-protein kinase pim-1, Pimtide, GLYCEROL, ... (5 entities in total)
Functional Keywords	serine kinase, kinase, complex, pim1, pim, pim-1, inhibitor, tumorigenisis, cancer, pimtide, proto oncogen, atp, phosphorylation, apoptosis, cell cycle, transferase
Biological source	Homo sapiens (human) More
Total number of polymer chains	2
Total formula weight	37562.65
Authors	Hochban, P.M.M.,Heine, A.,Diederich, W.E. (deposition date: 2021-11-18, release date: 2022-11-30, Last modification date: 2024-02-07)
Primary citation	Heyder, L.,Hochban, P.M.M.,Taylor, C.,Chevillard, F.,Siefker, C.,Iking, C.,Borchardt, H.,Aigner, A.,Klebe, G.,Heine, A.,Kolb, P.,Diederich, W.E. Pose, duplicate, then elaborate: Steps towards increased affinity for inhibitors targeting the specificity surface of the Pim-1 kinase. Eur.J.Med.Chem., 245:114914-114914, 2023 Cited by PubMed: 36410167 DOI: 10.1016/j.ejmech.2022.114914 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.53 Å)

Structure validation