4XHK

PIM1 kinase in complex with Compound 1s

Summary for 4XHK

Entry DOI	10.2210/pdb4xhk/pdb
Related	4X7Q
Descriptor	Serine/threonine-protein kinase pim-1, 2-(2,6-difluorophenyl)-N-{4-[(3S)-pyrrolidin-3-yloxy]pyridin-3-yl}-1,3-thiazole-4-carboxamide (3 entities in total)
Functional Keywords	transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Homo sapiens (Human)
Cellular location	Isoform 2: Cytoplasm. Isoform 1: Cell membrane: P11309
Total number of polymer chains	1
Total formula weight	36369.31
Authors	Marcotte, D.J.,Silvian, L.F. (deposition date: 2015-01-05, release date: 2015-02-11, Last modification date: 2023-09-27)
Primary citation	Ishchenko, A.,Zhang, L.,Le Brazidec, J.Y.,Fan, J.,Chong, J.H.,Hingway, A.,Raditsis, A.,Singh, L.,Elenbaas, B.,Hong, V.S.,Marcotte, D.,Silvian, L.,Enyedy, I.,Chao, J. Structure-based design of low-nanomolar PIM kinase inhibitors. Bioorg.Med.Chem.Lett., 25:474-480, 2015 Cited by PubMed: 25575657 DOI: 10.1016/j.bmcl.2014.12.041 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.9 Å)

Structure validation