4XHK
PIM1 kinase in complex with Compound 1s
Summary for 4XHK
Entry DOI | 10.2210/pdb4xhk/pdb |
Related | 4X7Q |
Descriptor | Serine/threonine-protein kinase pim-1, 2-(2,6-difluorophenyl)-N-{4-[(3S)-pyrrolidin-3-yloxy]pyridin-3-yl}-1,3-thiazole-4-carboxamide (3 entities in total) |
Functional Keywords | transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (Human) |
Cellular location | Isoform 2: Cytoplasm. Isoform 1: Cell membrane: P11309 |
Total number of polymer chains | 1 |
Total formula weight | 36369.31 |
Authors | Marcotte, D.J.,Silvian, L.F. (deposition date: 2015-01-05, release date: 2015-02-11, Last modification date: 2023-09-27) |
Primary citation | Ishchenko, A.,Zhang, L.,Le Brazidec, J.Y.,Fan, J.,Chong, J.H.,Hingway, A.,Raditsis, A.,Singh, L.,Elenbaas, B.,Hong, V.S.,Marcotte, D.,Silvian, L.,Enyedy, I.,Chao, J. Structure-based design of low-nanomolar PIM kinase inhibitors. Bioorg.Med.Chem.Lett., 25:474-480, 2015 Cited by PubMed: 25575657DOI: 10.1016/j.bmcl.2014.12.041 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.9 Å) |
Structure validation
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