3U84

Crystal Structure of Human Menin

Summary for 3U84

• Entry DOI: 10.2210/pdb3u84/pdb
• Related: 3U85 3U86 3U88
• Descriptor: Menin (2 entities in total)
• Functional Keywords: menin, men1, mll, jund, ledgf, tpr, transglutaminase-like, transcription, epigenetics, cancer
• Biological source: Homo sapiens (Human); More
• Cellular location: Nucleus : O00255
• Total number of polymer chains: 2
• Total formula weight: 122122.47

Authors

Huang, J.,Wan, B.,Lei, M. (deposition date: 2011-10-15, release date: 2012-02-15, Last modification date: 2024-02-28)

• Primary citation: Huang, J.,Gurung, B.,Wan, B.,Matkar, S.,Veniaminova, N.A.,Wan, K.,Merchant, J.L.,Hua, X.,Lei, M.; The same pocket in menin binds both MLL and JUND but has opposite effects on transcription.; Nature, 482:542-546, 2012; PubMed: 22327296; DOI: 10.1038/nature10806

Experimental method

X-RAY DIFFRACTION (2.5 Å)