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4GE2	Crystal structure of human protein tyrosine phosphatase PTPN9 (MEG2) complex with compound 3 Descriptor: N-acetyl-4-[difluoro(phosphono)methyl]-L-phenylalanyl-N~5~-(3-iodobenzoyl)-L-ornithinamide, Tyrosine-protein phosphatase non-receptor type 9 Authors: Zhang, Z.-Y, Liu, S, Zhang, S. Deposit date: 2012-08-01 Release date: 2012-10-31 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.8 Å) Cite: A Highly Selective and Potent PTP-MEG2 Inhibitor with Therapeutic Potential for Type 2 Diabetes. J.Am.Chem.Soc., 134, 2012
4GFU	PTPN18 in complex with HER2-pY1248 phosphor-peptides Descriptor: HER2-pY1248 phosphor-peptide, Tyrosine-protein phosphatase non-receptor type 18 Authors: Wang, H.M, Yang, F, Du, Y.J, Yang, D.X, Zhang, Y, Yu, X, Sun, J.P. Deposit date: 2012-08-04 Release date: 2013-08-07 Last modified: 2023-12-06 Method: X-RAY DIFFRACTION (2 Å) Cite: PTPN18-HER2 peptides To be Published
4QBE	The second sphere residue T263 is important for function and activity of PTP1B through modulating WPD loop Descriptor: Tyrosine-protein phosphatase non-receptor type 1 Authors: Xiao, P, Wang, X, Wang, H.M, Fu, X.L, Cui, F.A, Yu, X, Bi, W.X. Deposit date: 2014-05-08 Release date: 2014-12-24 Last modified: 2024-03-20 Method: X-RAY DIFFRACTION (2.292 Å) Cite: The second-sphere residue T263 is important for the function and catalytic activity of PTP1B via interaction with the WPD-loop Int.J.Biochem.Cell Biol., 57C, 2014
4GE5	Crystal structure of human protein tyrosine phosphatase PTPN9 (MEG2) complex with compound 5 Descriptor: N-(4-bromo-3-methylbenzoyl)-4-[difluoro(phosphono)methyl]-L-phenylalanyl-N~5~-(3-iodobenzoyl)-L-ornithinamide, Tyrosine-protein phosphatase non-receptor type 9 Authors: Zhang, Z.-Y, Liu, S, Zhang, S. Deposit date: 2012-08-01 Release date: 2012-10-31 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (2 Å) Cite: A Highly Selective and Potent PTP-MEG2 Inhibitor with Therapeutic Potential for Type 2 Diabetes. J.Am.Chem.Soc., 134, 2012
4QBW	The second sphere residue T263 is important for function and activity of PTP1B through modulating WPD loop Descriptor: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Tyrosine-protein phosphatase non-receptor type 1 Authors: Xiao, P, Wang, X, Wang, H.M, Fu, X.L, Cui, F.A, Yu, X, Bi, W.X, Sun, J.P. Deposit date: 2014-05-08 Release date: 2015-02-11 Last modified: 2024-03-20 Method: X-RAY DIFFRACTION (1.912 Å) Cite: The second-sphere residue T263 is important for the function and catalytic activity of PTP1B via interaction with the WPD-loop Int.J.Biochem.Cell Biol., 57, 2014
4HJQ	SHP-1 catalytic domain WPD loop closed Descriptor: PHOSPHATE ION, Tyrosine-protein phosphatase non-receptor type 6 Authors: Alicea-Velazquez, N.L, Boggon, T.J. Deposit date: 2012-10-13 Release date: 2013-04-03 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (1.8013 Å) Cite: SHP Family Protein Tyrosine Phosphatases Adopt Canonical Active-Site Conformations in the Apo and Phosphate-Bound States. Protein Pept.Lett., 20, 2013
4HJP	SHP-1 catalytic domain WPD loop open Descriptor: Tyrosine-protein phosphatase non-receptor type 6 Authors: Alicea-Velazquez, N.L, Boggon, T.J. Deposit date: 2012-10-13 Release date: 2013-04-03 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (1.3994 Å) Cite: SHP Family Protein Tyrosine Phosphatases Adopt Canonical Active-Site Conformations in the Apo and Phosphate-Bound States. Protein Pept.Lett., 20, 2013
4I8N	CRYSTAL STRUCTURE of PROTEIN TYROSINE PHOSPHATASE 1B IN COMPLEX WITH AN INHIBITOR [(4-{(2S)-2-(1,3-BENZOXAZOL-2-YL)-2-[(4-FLUOROPHENYL)SULFAMOYL]ETHYL}PHENYL)AMINO](OXO)ACETIC ACID Descriptor: Tyrosine-protein phosphatase non-receptor type 1, [(4-{(2S)-2-(1,3-benzoxazol-2-yl)-2-[(4-fluorophenyl)sulfamoyl]ethyl}phenyl)amino](oxo)acetic acid Authors: Reddy, S.M.V.V.V, Rao, K.N, Subramanya, H. Deposit date: 2012-12-03 Release date: 2012-12-26 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (2.5 Å) Cite: X-Ray Structure of PTP1B in Complex with a New PTP1B Inhibitor. Protein Pept.Lett., 21, 2014
4IKC	Crystal Structure of catalytic domain of PTPRQ Descriptor: CHLORIDE ION, Phosphotidylinositol phosphatase PTPRQ, SULFATE ION Authors: Yu, K.R, Ryu, S.E, Kim, S.J. Deposit date: 2012-12-26 Release date: 2013-07-31 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (1.56 Å) Cite: Structural basis for the dephosphorylating activity of PTPRQ towards phosphatidylinositide substrates Acta Crystallogr.,Sect.D, 69, 2013
4QUN	Crystal structure of the PTPN3 (PTPH1) catalytic domain C842S mutant Descriptor: GLYCEROL, PHOSPHATE ION, Tyrosine-protein phosphatase non-receptor type 3 Authors: Chen, K.E, Meng, T.C, Wang, A.H.J. Deposit date: 2014-07-11 Release date: 2014-12-10 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (1.86 Å) Cite: Reciprocal allosteric regulation of p38 gamma and PTPN3 involves a PDZ domain-modulated complex formation. Sci.Signal., 7, 2014
4GFV	PTPN18 in complex with HER2-pY1196 phosphor-peptides Descriptor: HER2-pY1196 phosphor-peptide, Tyrosine-protein phosphatase non-receptor type 18 Authors: Wang, H.M, Yang, F, Du, Y.J, Yang, D.X, Zhang, Y, Yu, X, Sun, J.P. Deposit date: 2012-08-04 Release date: 2013-10-23 Last modified: 2023-12-06 Method: X-RAY DIFFRACTION (2.095 Å) Cite: PTPN18-HER2 peptides To be Published
4QUM	Crystal structure of PTPN3 (PTPH1) in complex with a dually phosphorylated MAPK12 peptide Descriptor: Mitogen-activated protein kinase 12, Tyrosine-protein phosphatase non-receptor type 3 Authors: Chen, K.E, Meng, T.C, Wang, A.H.J. Deposit date: 2014-07-10 Release date: 2014-12-10 Last modified: 2023-12-06 Method: X-RAY DIFFRACTION (2.516 Å) Cite: Reciprocal allosteric regulation of p38 gamma and PTPN3 involves a PDZ domain-modulated complex formation. Sci.Signal., 7, 2014
4RDD	Co-crystal structure of SHP2 in complex with a Cefsulodin derivative Descriptor: 1-({(2R)-4-carboxy-2-[(R)-carboxy{[(2R)-2-phenyl-2-sulfoacetyl]amino}methyl]-3,6-dihydro-2H-1,3-thiazin-5-yl}methyl)pyridinium, Tyrosine-protein phosphatase non-receptor type 11 Authors: Zhang, Z.Y, Yu, Z.H, He, R, Zhang, R.Y. Deposit date: 2014-09-18 Release date: 2015-07-01 Last modified: 2015-12-16 Method: X-RAY DIFFRACTION (1.601 Å) Cite: Exploring the Existing Drug Space for Novel pTyr Mimetic and SHP2 Inhibitors. ACS Med Chem Lett, 6, 2015
4RH5	Crystal structure of PTPN3 (PTPH1) in complex with Eps15 pTyr849 peptide Descriptor: Epidermal growth factor receptor substrate 15, Tyrosine-protein phosphatase non-receptor type 3 Authors: Chen, K.-E, Meng, T.C, Wang, A.H.-J. Deposit date: 2014-10-01 Release date: 2015-03-11 Last modified: 2023-12-06 Method: X-RAY DIFFRACTION (1.6 Å) Cite: Substrate specificity and plasticity of FERM-containing protein tyrosine phosphatases. Structure, 23, 2015
4RH9	Crystal structure of PTPN3 (PTPH1) H812F, M883G mutant in complex with Eps15 pTyr849 peptide Descriptor: Epidermal growth factor receptor substrate 15, Tyrosine-protein phosphatase non-receptor type 3 Authors: Chen, K.-E, Meng, T.C, Wang, A.H.-J. Deposit date: 2014-10-01 Release date: 2015-03-11 Last modified: 2023-12-06 Method: X-RAY DIFFRACTION (1.598 Å) Cite: Substrate specificity and plasticity of FERM-containing protein tyrosine phosphatases. Structure, 23, 2015
4RHG	Crystal structure of PTPN3 (PTPH1) D811E, C842S mutant in complex with Eps15 pTyr849 peptide Descriptor: Epidermal growth factor receptor substrate 15, Tyrosine-protein phosphatase non-receptor type 3 Authors: Chen, K.-E, Meng, T.C, Wang, A.H.-J. Deposit date: 2014-10-02 Release date: 2015-03-11 Last modified: 2023-12-06 Method: X-RAY DIFFRACTION (1.581 Å) Cite: Substrate specificity and plasticity of FERM-containing protein tyrosine phosphatases. Structure, 23, 2015
4ICZ	HER2 1221/1222 phosphorylation regulated by PTPN9 Descriptor: HER2, Tyrosine-protein phosphatase non-receptor type 9 Authors: Xu, Y.F, Wang, H.M, Liu, C.H, Yu, X, Sun, J.P. Deposit date: 2012-12-11 Release date: 2013-12-11 Method: X-RAY DIFFRACTION (1.9 Å) Cite: HER2 1221/1222 phosphorylation regulated by PTPN9 To be Published
4RI4	Crystal structure of PTPN3 (PTPH1) Y676I mutant in complex with vanadate Descriptor: Tyrosine-protein phosphatase non-receptor type 3, VANADATE ION Authors: Chen, K.-E, Meng, T.C, Wang, A.H.-J. Deposit date: 2014-10-05 Release date: 2015-03-11 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (1.596 Å) Cite: Substrate specificity and plasticity of FERM-containing protein tyrosine phosphatases. Structure, 23, 2015
4RI5	Crystal structure of PTPN3 (PTPH1) D811E mutant in complex with metavanadate Descriptor: GLYCEROL, Tyrosine-protein phosphatase non-receptor type 3, oxido(dioxo)vanadium Authors: Chen, K.-E, Meng, T.C, Wang, A.H.-J. Deposit date: 2014-10-05 Release date: 2015-03-11 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (1.26 Å) Cite: Substrate specificity and plasticity of FERM-containing protein tyrosine phosphatases. Structure, 23, 2015
4GRZ	Crystal structure of SHP1 catalytic domain with PO4 Descriptor: PHOSPHATE ION, Tyrosine-protein phosphatase non-receptor type 6 Authors: Alicea-Velazquez, N.L, Jakoncic, J, Boggon, T.J. Deposit date: 2012-08-27 Release date: 2012-12-19 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.3732 Å) Cite: Structure-guided studies of the SHP-1/JAK1 interaction provide new insights into phosphatase catalytic domain substrate recognition. J.Struct.Biol., 181, 2013
4QAP	The second sphere residue T263 is important for function and activity of PTP1B through modulating WPD loop Descriptor: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Tyrosine-protein phosphatase non-receptor type 1 Authors: Xiao, P, Wang, X, Wang, H.M, Fu, X.L, Cui, F.A, Yu, X, Bi, W.X, Sun, J.P. Deposit date: 2014-05-05 Release date: 2015-02-11 Last modified: 2024-03-20 Method: X-RAY DIFFRACTION (1.903 Å) Cite: The second-sphere residue T263 is important for the function and catalytic activity of PTP1B via interaction with the WPD-loop Int.J.Biochem.Cell Biol., 57, 2014
4GRY	Crystal structure of SHP1 catalytic domain with SO4 Descriptor: SULFATE ION, Tyrosine-protein phosphatase non-receptor type 6 Authors: Alicea-Velazquez, N.L, Jakoncic, J, Boggon, T.J. Deposit date: 2012-08-27 Release date: 2012-12-19 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.6998 Å) Cite: Structure-guided studies of the SHP-1/JAK1 interaction provide new insights into phosphatase catalytic domain substrate recognition. J.Struct.Biol., 181, 2013
4QAH	The second sphere residue T263 is important for function and activity of PTP1B through modulating WPD loop Descriptor: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Tyrosine-protein phosphatase non-receptor type 1 Authors: Xiao, P, Wang, X, Wang, H.M, Fu, X.L, Cui, F.A, Bi, W.X. Deposit date: 2014-05-05 Release date: 2014-12-24 Last modified: 2024-03-20 Method: X-RAY DIFFRACTION (2.403 Å) Cite: The second-sphere residue T263 is important for the function and catalytic activity of PTP1B via interaction with the WPD-loop Int.J.Biochem.Cell Biol., 57C, 2014
4J51	Cyrstal structure of protein tyrosine phosphatase Lyp catalytic domain complex with small molecular inhibitor L75N04 Descriptor: 3-[(3-chlorophenyl)ethynyl]-2-{4-[2-(cyclopropylamino)-2-oxoethoxy]phenyl}-6-hydroxy-1-benzofuran-5-carboxylic acid, Tyrosine-protein phosphatase non-receptor type 22 Authors: Liu, D, He, Y, Zhang, Z.-Y. Deposit date: 2013-02-07 Release date: 2013-07-24 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (2.3 Å) Cite: A Potent and Selective Small-Molecule Inhibitor for the Lymphoid-Specific Tyrosine Phosphatase (LYP), a Target Associated with Autoimmune Diseases. J.Med.Chem., 56, 2013
4S0G	Crystal structure of PTPN3 (PTPH1) in complex with Eps15 pTyr849 P850V peptide Descriptor: Peptide from Epidermal growth factor receptor substrate 15, Tyrosine-protein phosphatase non-receptor type 3 Authors: Chen, K.-E, Meng, T.C, Wang, A.H.-J. Deposit date: 2014-12-31 Release date: 2015-03-11 Last modified: 2023-12-06 Method: X-RAY DIFFRACTION (1.723 Å) Cite: Substrate specificity and plasticity of FERM-containing protein tyrosine phosphatases. Structure, 23, 2015

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