4J51

Cyrstal structure of protein tyrosine phosphatase Lyp catalytic domain complex with small molecular inhibitor L75N04

Summary for 4J51

Entry DOI	10.2210/pdb4j51/pdb
Descriptor	Tyrosine-protein phosphatase non-receptor type 22, 3-[(3-chlorophenyl)ethynyl]-2-{4-[2-(cyclopropylamino)-2-oxoethoxy]phenyl}-6-hydroxy-1-benzofuran-5-carboxylic acid (3 entities in total)
Functional Keywords	hydrolase, tyrosine phosphatase, inhibitor design, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm (By similarity): Q9Y2R2
Total number of polymer chains	2
Total formula weight	77269.10
Authors	Liu, D.,He, Y.,Zhang, Z.-Y. (deposition date: 2013-02-07, release date: 2013-07-24, Last modification date: 2023-09-20)
Primary citation	He, Y.,Liu, S.,Menon, A.,Stanford, S.,Oppong, E.,Gunawan, A.M.,Wu, L.,Wu, D.J.,Barrios, A.M.,Bottini, N.,Cato, A.C.,Zhang, Z.Y. A Potent and Selective Small-Molecule Inhibitor for the Lymphoid-Specific Tyrosine Phosphatase (LYP), a Target Associated with Autoimmune Diseases. J.Med.Chem., 56:4990-5008, 2013 Cited by PubMed: 23713581 DOI: 10.1021/jm400248c PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.3 Å)

Structure validation