4J51
Cyrstal structure of protein tyrosine phosphatase Lyp catalytic domain complex with small molecular inhibitor L75N04
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004725 | molecular_function | protein tyrosine phosphatase activity |
| A | 0004726 | molecular_function | non-membrane spanning protein tyrosine phosphatase activity |
| A | 0006470 | biological_process | protein dephosphorylation |
| A | 0016311 | biological_process | dephosphorylation |
| B | 0004725 | molecular_function | protein tyrosine phosphatase activity |
| B | 0004726 | molecular_function | non-membrane spanning protein tyrosine phosphatase activity |
| B | 0006470 | biological_process | protein dephosphorylation |
| B | 0016311 | biological_process | dephosphorylation |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE N75 A 401 |
| Chain | Residue |
| A | TYR60 |
| A | GLN274 |
| A | GLN278 |
| A | LYS61 |
| A | ASP62 |
| A | CYS227 |
| A | SER228 |
| A | ALA229 |
| A | CYS231 |
| A | GLY232 |
| A | ARG233 |
| site_id | AC2 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE N75 B 401 |
| Chain | Residue |
| B | TYR60 |
| B | LYS61 |
| B | ASP62 |
| B | CYS227 |
| B | SER228 |
| B | ALA229 |
| B | CYS231 |
| B | GLY232 |
| B | ARG233 |
| B | GLN274 |
| B | THR275 |
| B | GLN278 |
| B | HOH519 |
Functional Information from PROSITE/UniProt
| site_id | PS00383 |
| Number of Residues | 11 |
| Details | TYR_PHOSPHATASE_1 Tyrosine specific protein phosphatases active site. IHCsaGcgRTG |
| Chain | Residue | Details |
| A | ILE225-GLY235 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Phosphocysteine intermediate","evidences":[{"source":"PROSITE-ProRule","id":"PRU00160","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU10044","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 14 |
| Details | Binding site: {"evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"DEC-2009","submissionDatabase":"PDB data bank","title":"Lyp/PTPN22 phosphatase domain: substrate recognition and specificity for Src family kinases.","authors":["Seidel R.D.","Love J.","Piserchio A.","Cowburn D."]}}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphoserine; by PKC/PRKCD","evidences":[{"source":"PubMed","id":"18056643","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
