4J51
Cyrstal structure of protein tyrosine phosphatase Lyp catalytic domain complex with small molecular inhibitor L75N04
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | Tyrosine-protein phosphatase non-receptor type 22 | polymer | 326 | 38132.6 | 2 | UniProt (Q9Y2R2) Pfam (PF00102) In PDB | Homo sapiens (human) | Hematopoietic cell protein-tyrosine phosphatase 70Z-PEP, Lymphoid phosphatase, LyP, PEST-domain phosphatase, PEP |
2 | A, B | 3-[(3-chlorophenyl)ethynyl]-2-{4-[2-(cyclopropylamino)-2-oxoethoxy]phenyl}-6-hydroxy-1-benzofuran-5-carboxylic acid | non-polymer | 501.9 | 2 | Chemie (N75) | |||
3 | water | water | 18.0 | 48 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 303 (UniProt: Q9Y2R2)
PDB | External Database | Details |
---|---|---|
Met -22 | - | expression tag |
Gly -21 | - | expression tag |
Ser -20 | - | expression tag |
Ser -19 | - | expression tag |
His -18 | - | expression tag |
His -17 | - | expression tag |
His -16 | - | expression tag |
His -15 | - | expression tag |
His -14 | - | expression tag |
His -13 | - | expression tag |
Ser -12 | - | expression tag |
Ser -11 | - | expression tag |
Gly -10 | - | expression tag |
Leu -9 | - | expression tag |
Val -8 | - | expression tag |
Pro -7 | - | expression tag |
Arg -6 | - | expression tag |
Gly -5 | - | expression tag |
Ser -4 | - | expression tag |
His -3 | - | expression tag |
Met -2 | - | expression tag |
Ala -1 | - | expression tag |
Ser 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 76265.3 | |
Non-Polymers* | Number of molecules | 2 |
Total formula weight | 1003.8 | |
All* | Total formula weight | 77269.1 |