4I8N
CRYSTAL STRUCTURE of PROTEIN TYROSINE PHOSPHATASE 1B IN COMPLEX WITH AN INHIBITOR [(4-{(2S)-2-(1,3-BENZOXAZOL-2-YL)-2-[(4-FLUOROPHENYL)SULFAMOYL]ETHYL}PHENYL)AMINO](OXO)ACETIC ACID
Summary for 4I8N
Entry DOI | 10.2210/pdb4i8n/pdb |
Related | 2VEU |
Descriptor | Tyrosine-protein phosphatase non-receptor type 1, [(4-{(2S)-2-(1,3-benzoxazol-2-yl)-2-[(4-fluorophenyl)sulfamoyl]ethyl}phenyl)amino](oxo)acetic acid (3 entities in total) |
Functional Keywords | protein phosphatase, ptp1b, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side: P18031 |
Total number of polymer chains | 1 |
Total formula weight | 41287.92 |
Authors | Reddy, S.M.V.V.V.,Rao, K.N.,Subramanya, H. (deposition date: 2012-12-03, release date: 2012-12-26, Last modification date: 2024-02-28) |
Primary citation | Reddy, M.V.,Ghadiyaram, C.,Panigrahi, S.K.,Krishnamurthy, N.R.,Hosahalli, S.,Chandrasekharappa, A.P.,Manna, D.,Badiger, S.E.,Dubey, P.K.,Mangamoori, L.N. X-Ray Structure of PTP1B in Complex with a New PTP1B Inhibitor. Protein Pept.Lett., 21:90-93, 2014 Cited by PubMed: 23964742PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.5 Å) |
Structure validation
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