4I8N
CRYSTAL STRUCTURE of PROTEIN TYROSINE PHOSPHATASE 1B IN COMPLEX WITH AN INHIBITOR [(4-{(2S)-2-(1,3-BENZOXAZOL-2-YL)-2-[(4-FLUOROPHENYL)SULFAMOYL]ETHYL}PHENYL)AMINO](OXO)ACETIC ACID
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Tyrosine-protein phosphatase non-receptor type 1 | polymer | 354 | 40804.4 | 1 | UniProt (P18031) Pfam (PF00102) In PDB | Homo sapiens (human) | Protein-tyrosine phosphatase 1B, PTP-1B |
2 | A | [(4-{(2S)-2-(1,3-benzoxazol-2-yl)-2-[(4-fluorophenyl)sulfamoyl]ethyl}phenyl)amino](oxo)acetic acid | non-polymer | 483.5 | 1 | Chemie (1CG) | |||
3 | water | water | 18.0 | 58 | Chemie (HOH) |
Sequence modifications
A: 1 - 320 (UniProt: P18031)
PDB | External Database | Details |
---|---|---|
Met -33 | - | expression tag |
Gly -32 | - | expression tag |
Ser -31 | - | expression tag |
Ser -30 | - | expression tag |
His -29 | - | expression tag |
His -28 | - | expression tag |
His -27 | - | expression tag |
His -26 | - | expression tag |
His -25 | - | expression tag |
His -24 | - | expression tag |
Ser -23 | - | expression tag |
Ser -22 | - | expression tag |
Gly -21 | - | expression tag |
Leu -20 | - | expression tag |
Val -19 | - | expression tag |
Pro -18 | - | expression tag |
Arg -17 | - | expression tag |
Gly -16 | - | expression tag |
Ser -15 | - | expression tag |
His -14 | - | expression tag |
Met -13 | - | expression tag |
Ala -12 | - | expression tag |
Ser -11 | - | expression tag |
Met -10 | - | expression tag |
Thr -9 | - | expression tag |
Gly -8 | - | expression tag |
Gly -7 | - | expression tag |
Gln -6 | - | expression tag |
Gln -5 | - | expression tag |
Met -4 | - | expression tag |
Gly -3 | - | expression tag |
Arg -2 | - | expression tag |
Gly -1 | - | expression tag |
Ser 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 40804.4 | |
Non-Polymers* | Number of molecules | 1 |
Total formula weight | 483.5 | |
All* | Total formula weight | 41287.9 |