PDB: 1320 resultsInfo pagesStatus searchChemie searchBIRD

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6P0L	Crystal structure of GDP-bound human RalA in a covalent complex with aryl sulfonyl fluoride compounds. Descriptor: 4-[(2-methoxypyridin-3-yl)sulfamoyl]benzene-1-sulfonic acid, CALCIUM ION, GUANOSINE-5'-DIPHOSPHATE, ... Authors: Bum-Erdene, K, Gonzalez-Gutierrez, G, Liu, D, Ghozayel, M.K, Xu, D, Meroueh, S.O. Deposit date: 2019-05-17 Release date: 2020-03-04 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (1.3 Å) Cite: Small-molecule covalent bond formation at tyrosine creates a binding site and inhibits activation of Ral GTPases. Proc.Natl.Acad.Sci.USA, 117, 2020
6P8W	Crystal structure of human KRAS G12C covalently bound to an acryloylazetidine acetamide inhibitor. Descriptor: CALCIUM ION, GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, ... Authors: Mohr, C. Deposit date: 2019-06-08 Release date: 2019-08-28 Last modified: 2019-10-02 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Discovery ofN-(1-Acryloylazetidin-3-yl)-2-(1H-indol-1-yl)acetamides as Covalent Inhibitors of KRASG12C. Acs Med.Chem.Lett., 10, 2019
3I3S	Crystal Structure of H-Ras with Thr50 replaced by Isoleucine Descriptor: CALCIUM ION, GTPase HRas, MAGNESIUM ION, ... Authors: Gremer, L, Dvorsky, R, Merbitz-Zahradnik, T, Wittinghofer, A, Ahmadian, M.R. Deposit date: 2009-06-30 Release date: 2009-12-22 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (1.36 Å) Cite: A restricted spectrum of NRAS mutations causes Noonan syndrome. Nat.Genet., 42, 2010
6PGP	Crystal structure of human KRAS G12C covalently bound to a quinazolinone inhibitor Descriptor: 6-chloro-7-(2-fluoro-6-hydroxyphenyl)-4-(4-propanoylpiperazin-1-yl)-1-[2-(propan-2-yl)phenyl]quinazolin-2(1H)-one, CALCIUM ION, GTPase KRas, ... Authors: Mohr, C, Whittington, D.A. Deposit date: 2019-06-24 Release date: 2019-12-25 Last modified: 2020-01-22 Method: X-RAY DIFFRACTION (1.5 Å) Cite: Discovery of a Covalent Inhibitor of KRASG12C(AMG 510) for the Treatment of Solid Tumors. J.Med.Chem., 63, 2020
7ACF	CRYSTAL STRUCTURE OF CRYSTAL FORM 2 OF AN ACTIVE KRAS G12D (GPPCP) DIMER IN COMPLEX WITH BI-5747 Descriptor: (3~{S})-5-oxidanyl-3-[2-[[6-[[3-[(1~{S})-6-oxidanyl-3-oxidanylidene-1,2-dihydroisoindol-1-yl]-1~{H}-indol-2-yl]methylamino]hexylamino]methyl]-1~{H}-indol-3-yl]-2,3-dihydroisoindol-1-one, GTPase KRas, MAGNESIUM ION, ... Authors: Kessler, D. Deposit date: 2020-09-10 Release date: 2020-11-18 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (1.91 Å) Cite: Reply to Tran et al.: Dimeric KRAS protein-protein interaction stabilizers. Proc. Natl. Acad. Sci. U.S.A., 117, 2020
6P8Y	Crystal structure of human KRAS G12C covalently bound to an acryloylazetidine acetamide inhibitor. Descriptor: 2-[5-bromo-3-(5-methoxy-3,4-dihydroisoquinoline-2(1H)-carbonyl)-1H-indol-1-yl]-N-(1-propanoylazetidin-3-yl)acetamide, GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, ... Authors: Mohr, C. Deposit date: 2019-06-08 Release date: 2019-08-28 Last modified: 2019-10-02 Method: X-RAY DIFFRACTION (2.31 Å) Cite: Discovery ofN-(1-Acryloylazetidin-3-yl)-2-(1H-indol-1-yl)acetamides as Covalent Inhibitors of KRASG12C. Acs Med.Chem.Lett., 10, 2019
7ACA	CRYSTAL STRUCTURE OF AN ACTIVE KRAS G12D (GPPCP) DIMER IN COMPLEX WITH BI-5747 Descriptor: (3~{S})-5-oxidanyl-3-[2-[[6-[[3-[(1~{S})-6-oxidanyl-3-oxidanylidene-1,2-dihydroisoindol-1-yl]-1~{H}-indol-2-yl]methylamino]hexylamino]methyl]-1~{H}-indol-3-yl]-2,3-dihydroisoindol-1-one, 1,2-ETHANEDIOL, GTPase KRas, ... Authors: Kessler, D. Deposit date: 2020-09-10 Release date: 2020-11-18 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (1.57 Å) Cite: CRYSTAL STRUCTURE OF AN ACTIVE KRAS G12D (GPPCP) DIMER IN COMPLEX WITH BI-5747 To Be Published
6P8X	Crystal structure of human KRAS G12C covalently bound to an acryloylazetidine acetamide inhibitor. Descriptor: 2-[4-bromo-2-(3-phenyl-2,5-dihydro-1H-pyrrole-1-carbonyl)phenoxy]-N-(1-propanoylazetidin-3-yl)acetamide, CALCIUM ION, GTPase KRas, ... Authors: Mohr, C. Deposit date: 2019-06-08 Release date: 2019-08-28 Last modified: 2019-10-02 Method: X-RAY DIFFRACTION (2.11 Å) Cite: Discovery ofN-(1-Acryloylazetidin-3-yl)-2-(1H-indol-1-yl)acetamides as Covalent Inhibitors of KRASG12C. Acs Med.Chem.Lett., 10, 2019
7ACQ	CRYSTAL STRUCTURE OF INACTIVE KRAS G12D (GDP) IN COMPLEX WITH THE SOAKED DIMERIC INHIBITOR BI-5747 Descriptor: (3~{S})-5-oxidanyl-3-[2-[[6-[[3-[(1~{S})-6-oxidanyl-3-oxidanylidene-1,2-dihydroisoindol-1-yl]-1~{H}-indol-2-yl]methylamino]hexylamino]methyl]-1~{H}-indol-3-yl]-2,3-dihydroisoindol-1-one, GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, ... Authors: Kessler, D. Deposit date: 2020-09-11 Release date: 2020-11-18 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (1.86 Å) Cite: CRYSTAL STRUCTURE OF INACTIVE KRAS G12D (GDP) IN COMPLEX WITH THE SOAKED DIMERIC INHIBITOR BI00925747 To Be Published
721P	THREE-DIMENSIONAL STRUCTURES OF H-RAS P21 MUTANTS: MOLECULAR BASIS FOR THEIR INABILITY TO FUNCTION AS SIGNAL SWITCH MOLECULES Descriptor: H-RAS P21 PROTEIN, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER Authors: Krengel, U, Scherer, A, Kabsch, W, Wittinghofer, A, Pai, E.F. Deposit date: 1991-06-06 Release date: 1994-01-31 Last modified: 2024-03-06 Method: X-RAY DIFFRACTION (2 Å) Cite: Three-dimensional structures of H-ras p21 mutants: molecular basis for their inability to function as signal switch molecules. Cell(Cambridge,Mass.), 62, 1990
6PQ3	Crystal structure of GDP-bound KRAS with ten residues long internal tandem duplication in the switch II region Descriptor: GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... Authors: Dharmaiah, S, Chan, A.H, Tran, T.H, Simanshu, D.K. Deposit date: 2019-07-08 Release date: 2020-05-20 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (1.75 Å) Cite: RASinternal tandem duplication disrupts GTPase-activating protein (GAP) binding to activate oncogenic signaling. J.Biol.Chem., 295, 2020
3IHW	Crystal structure of the Ras-like domain of CENTG3 Descriptor: CENTG3, UNKNOWN ATOM OR ION Authors: Nedyalkova, L, Tempel, W, Tong, Y, Li, Y, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Weigelt, J, Bochkarev, A, Park, H, Structural Genomics Consortium (SGC) Deposit date: 2009-07-30 Release date: 2009-08-11 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (1.92 Å) Cite: Crystal structure of the Ras-like domain of CENTG3 to be published
7ACH	CRYSTAL STRUCTURE OF ACTIVE KRAS G12D (GPPCP) IN COMPLEX WITH THE SOAKED DIMERIC INHIBITOR BI-5747 Descriptor: (3~{S})-5-oxidanyl-3-[2-[[6-[[3-[(1~{S})-6-oxidanyl-3-oxidanylidene-1,2-dihydroisoindol-1-yl]-1~{H}-indol-2-yl]methylamino]hexylamino]methyl]-1~{H}-indol-3-yl]-2,3-dihydroisoindol-1-one, GTPase KRas, MAGNESIUM ION, ... Authors: Kessler, D. Deposit date: 2020-09-10 Release date: 2020-11-18 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (1.9 Å) Cite: CRYSTAL STRUCTURE OF ACTIVE KRAS G12D (GPPCP) IN COMPLEX WITH THE SOAKED DIMERIC INHIBITOR BI-5747 To Be Published
1VG8	GPPNHP-Bound Rab7 Descriptor: MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, Ras-related protein Rab-7 Authors: Rak, A, Pylypenko, O, Niculae, A, Pyatkov, K, Goody, R.S, Alexandrov, K. Deposit date: 2004-04-23 Release date: 2004-07-20 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Structure of the Rab7:REP-1 complex: insights into the mechanism of Rab prenylation and choroideremia disease Cell(Cambridge,Mass.), 117, 2004
1VG1	GDP-Bound Rab7 Descriptor: GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Ras-related protein Rab-7 Authors: Rak, A, Pylypenko, O, Niculae, A, Pyatkov, K, Goody, R.S, Alexandrov, K. Deposit date: 2004-04-22 Release date: 2004-07-20 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Structure of the Rab7:REP-1 complex: insights into the mechanism of Rab prenylation and choroideremia disease Cell(Cambridge,Mass.), 117, 2004
7A1Y	KRASG12C GDP form in complex with Cpd2 Descriptor: GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... Authors: Mathieu, M, Steier, V. Deposit date: 2020-08-14 Release date: 2021-10-13 Last modified: 2022-01-12 Method: X-RAY DIFFRACTION (2.004 Å) Cite: KRAS G12C fragment screening renders new binding pockets. Small Gtpases, 13, 2022
7A1X	KRASG12C GDP form in complex with Cpd1 Descriptor: 3-(imidazol-1-ylmethyl)-1~{H}-indole, GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, ... Authors: Mathieu, M, Steier, V. Deposit date: 2020-08-14 Release date: 2021-10-13 Last modified: 2022-01-12 Method: X-RAY DIFFRACTION (1.32 Å) Cite: KRAS G12C fragment screening renders new binding pockets. Small Gtpases, 13, 2022
7A1W	KRASG12C GDP form in complex with Cpd3 Descriptor: GUANOSINE-5'-DIPHOSPHATE, Isoform 2B of GTPase KRas, MAGNESIUM ION, ... Authors: Mathieu, M, Steier, V. Deposit date: 2020-08-14 Release date: 2021-10-13 Last modified: 2022-01-12 Method: X-RAY DIFFRACTION (1.76 Å) Cite: KRAS G12C fragment screening renders new binding pockets. Small Gtpases, 13, 2022
7A47	KRASG12C GDP form in complex with Cpd4 Descriptor: GUANOSINE-5'-DIPHOSPHATE, Isoform 2B of GTPase KRas, ~{N}-[3-bromanyl-2-(2-methylimidazol-1-yl)pyridin-4-yl]-3-[[3-bromanyl-2-(2-methylimidazol-1-yl)pyridin-4-yl]-propanoyl-amino]propanamide Authors: Bertrand, T, Steier, V. Deposit date: 2020-08-19 Release date: 2021-10-13 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (2.16 Å) Cite: KRAS G12C fragment screening renders new binding pockets. Small Gtpases, 13, 2022
6Q21	MOLECULAR SWITCH FOR SIGNAL TRANSDUCTION: STRUCTURAL DIFFERENCES BETWEEN ACTIVE AND INACTIVE FORMS OF PROTOONCOGENIC RAS PROTEINS Descriptor: C-H-RAS P21 PROTEIN CATALYTIC DOMAIN, MAGNESIUM ION, PHOSPHOMETHYLPHOSPHONIC ACID GUANYLATE ESTER Authors: Kim, S.-H. Deposit date: 1992-07-27 Release date: 1992-07-28 Last modified: 2024-03-13 Method: X-RAY DIFFRACTION (1.95 Å) Cite: Molecular switch for signal transduction: structural differences between active and inactive forms of protooncogenic ras proteins. Science, 247, 1990
3K8Y	Allosteric modulation of H-Ras GTPase Descriptor: ACETATE ION, CALCIUM ION, GTPase HRas, ... Authors: Holzapfel, G, Buhrman, G, Mattos, C. Deposit date: 2009-10-15 Release date: 2010-03-02 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (1.3 Å) Cite: Allosteric modulation of Ras positions Q61 for a direct role in catalysis. Proc.Natl.Acad.Sci.USA, 107, 2010
3K9N	Allosteric modulation of H-Ras GTPase Descriptor: CALCIUM ION, GTPase HRas, MAGNESIUM ION, ... Authors: Fetics, S, Young, M, Buhrman, G, Mattos, C. Deposit date: 2009-10-16 Release date: 2010-03-02 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (2 Å) Cite: Allosteric modulation of Ras positions Q61 for a direct role in catalysis. Proc.Natl.Acad.Sci.USA, 107, 2010
3K9L	Allosteric modulation of H-Ras GTPase Descriptor: CALCIUM ION, GTPase HRas, MAGNESIUM ION, ... Authors: Fetics, S, Young, M, Buhrman, G, Mattos, C. Deposit date: 2009-10-15 Release date: 2010-11-03 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Allosteric modulation of H-Ras GTPase To be Published
1X1S	Crystal structure of M-Ras in complex with GppNHp Descriptor: MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, Ras-related protein M-Ras Authors: Ye, M, Shima, F, Muraoka, S, Liao, J, Okamoto, H, Yamamoto, M, Tamura, A, Yagi, N, Ueki, T, Kataoka, T. Deposit date: 2005-04-13 Release date: 2005-07-26 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Crystal Structure of M-Ras Reveals a GTP-bound "Off" State Conformation of Ras Family Small GTPases J.Biol.Chem., 280, 2005
1WMS	High resolution crystal structure of human Rab9 GTPase: a novel antiviral drug target Descriptor: GUANOSINE-5'-DIPHOSPHATE, Ras-related protein Rab-9A Authors: Chen, L, DiGiammarino, E, Zhou, X.E, Wang, Y, Toh, D, Hodge, T.W, Meehan, E.J. Deposit date: 2004-07-16 Release date: 2004-09-14 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (1.25 Å) Cite: High resolution crystal structure of human Rab9 GTPase: A novel antiviral drug target J.Biol.Chem., 279, 2004

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