7ACH

CRYSTAL STRUCTURE OF ACTIVE KRAS G12D (GPPCP) IN COMPLEX WITH THE SOAKED DIMERIC INHIBITOR BI-5747

Summary for 7ACH

• Entry DOI: 10.2210/pdb7ach/pdb
• Descriptor: GTPase KRas, (3~{S})-5-oxidanyl-3-[2-[[6-[[3-[(1~{S})-6-oxidanyl-3-oxidanylidene-1,2-dihydroisoindol-1-yl]-1~{H}-indol-2-yl]methylamino]hexylamino]methyl]-1~{H}-indol-3-yl]-2,3-dihydroisoindol-1-one, PHOSPHOMETHYLPHOSPHONIC ACID GUANYLATE ESTER, ... (5 entities in total)
• Functional Keywords: vienna, ppi, signaling protein
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 40533.51

Authors

Kessler, D. (deposition date: 2020-09-10, release date: 2020-11-18, Last modification date: 2024-01-31)

• Primary citation: Kessler, D.; CRYSTAL STRUCTURE OF ACTIVE KRAS G12D (GPPCP) IN COMPLEX WITH THE SOAKED DIMERIC INHIBITOR BI-5747; To Be Published,

Experimental method

X-RAY DIFFRACTION (1.9 Å)