7A1Y

KRASG12C GDP form in complex with Cpd2

Summary for 7A1Y

Entry DOI	10.2210/pdb7a1y/pdb
Descriptor	GTPase KRas, ~{N}-(3-bromanyl-2,6-dimethyl-pyridin-4-yl)propanamide, GUANOSINE-5'-DIPHOSPHATE, ... (6 entities in total)
Functional Keywords	inhibitor, mutant, oncoprotein
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	20195.60
Authors	Mathieu, M.,Steier, V. (deposition date: 2020-08-14, release date: 2021-10-13, Last modification date: 2022-01-12)
Primary citation	Mathieu, M.,Steier, V.,Fassy, F.,Delorme, C.,Papin, D.,Genet, B.,Duffieux, F.,Bertrand, T.,Delarbre, L.,Le-Borgne, H.,Parent, A.,Didier, P.,Marquette, J.P.,Lowinski, M.,Houtmann, J.,Lamberton, A.,Debussche, L.,Alexey, R. KRAS G12C fragment screening renders new binding pockets. Small Gtpases, 13:225-238, 2022 Cited by PubMed: 34558391 DOI: 10.1080/21541248.2021.1979360 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.004 Å)

Structure validation