7A47

KRASG12C GDP form in complex with Cpd4

Summary for 7A47

• Entry DOI: 10.2210/pdb7a47/pdb
• Descriptor: Isoform 2B of GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, ~{N}-[3-bromanyl-2-(2-methylimidazol-1-yl)pyridin-4-yl]-3-[[3-bromanyl-2-(2-methylimidazol-1-yl)pyridin-4-yl]-propanoyl-amino]propanamide, ... (4 entities in total)
• Functional Keywords: inhibitor, mutant, oncoprotein
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 3
• Total formula weight: 61303.23

Authors

Bertrand, T.,Steier, V. (deposition date: 2020-08-19, release date: 2021-10-13, Last modification date: 2024-01-31)

• Primary citation: Mathieu, M.,Steier, V.,Fassy, F.,Delorme, C.,Papin, D.,Genet, B.,Duffieux, F.,Bertrand, T.,Delarbre, L.,Le-Borgne, H.,Parent, A.,Didier, P.,Marquette, J.P.,Lowinski, M.,Houtmann, J.,Lamberton, A.,Debussche, L.,Alexey, R.; KRAS G12C fragment screening renders new binding pockets.; Small Gtpases, 13:225-238, 2022; PubMed: 34558391; DOI: 10.1080/21541248.2021.1979360

Experimental method

X-RAY DIFFRACTION (2.16 Å)