7A47
KRASG12C GDP form in complex with Cpd4
Summary for 7A47
Entry DOI | 10.2210/pdb7a47/pdb |
Descriptor | Isoform 2B of GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, ~{N}-[3-bromanyl-2-(2-methylimidazol-1-yl)pyridin-4-yl]-3-[[3-bromanyl-2-(2-methylimidazol-1-yl)pyridin-4-yl]-propanoyl-amino]propanamide, ... (4 entities in total) |
Functional Keywords | inhibitor, mutant, oncoprotein |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 3 |
Total formula weight | 61303.23 |
Authors | Bertrand, T.,Steier, V. (deposition date: 2020-08-19, release date: 2021-10-13, Last modification date: 2024-01-31) |
Primary citation | Mathieu, M.,Steier, V.,Fassy, F.,Delorme, C.,Papin, D.,Genet, B.,Duffieux, F.,Bertrand, T.,Delarbre, L.,Le-Borgne, H.,Parent, A.,Didier, P.,Marquette, J.P.,Lowinski, M.,Houtmann, J.,Lamberton, A.,Debussche, L.,Alexey, R. KRAS G12C fragment screening renders new binding pockets. Small Gtpases, 13:225-238, 2022 Cited by PubMed: 34558391DOI: 10.1080/21541248.2021.1979360 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.16 Å) |
Structure validation
Download full validation report