7A47
KRASG12C GDP form in complex with Cpd4
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C (A, C, E) | Isoform 2B of GTPase KRas | polymer | 170 | 19374.9 | 3 | UniProt (P01116-2) Pfam (PF00071) UniProt (by SIFTS) (P01116) | Homo sapiens (Human) | K-Ras 2,Ki-Ras,c-K-ras,c-Ki-ras |
| 2 | D, F, H (A, C, E) | GUANOSINE-5'-DIPHOSPHATE | non-polymer | 443.2 | 3 | Chemie (GDP) | |||
| 3 | E, G, I (A, C, E) | ~{N}-[3-bromanyl-2-(2-methylimidazol-1-yl)pyridin-4-yl]-3-[[3-bromanyl-2-(2-methylimidazol-1-yl)pyridin-4-yl]-propanoyl-amino]propanamide | non-polymer | 616.3 | 3 | Chemie (QY5) | |||
| 4 | J, K, L (A, C, E) | water | water | 18.0 | 211 | Chemie (HOH) |
Sequence modifications
A, C, E: 1 - 169 (UniProt: P01116-2)
| PDB | External Database | Details |
|---|---|---|
| Gly 0 | - | expression tag |
| Cys 12 | Gly 12 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 58124.7 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 3178.5 | |
| All* | Total formula weight | 61303.2 |
