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4O3A
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Crystal structure of the glua2 ligand-binding domain in complex with L-aspartate at 1.80 a resolution
Descriptor: ACETATE ION, ASPARTIC ACID, CHLORIDE ION, ...
Authors:Krintel, C, Frydenvang, F, Gajhede, M, Kastrup, J.S.
Deposit date:2013-12-18
Release date:2014-04-16
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:L-Asp is a useful tool in the purification of the ionotropic glutamate receptor A2 ligand-binding domain.
Febs J., 281, 2014
4O3B
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BU of 4o3b by Molmil
Crystal structure of an open/closed glua2 ligand-binding domain dimer at 1.91 A resolution
Descriptor: ACETATE ION, CHLORIDE ION, DI(HYDROXYETHYL)ETHER, ...
Authors:Krintel, C, de Rabassa, A.C, Frydenvang, K, Gajhede, M, Kastrup, J.S.
Deposit date:2013-12-18
Release date:2014-04-16
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.906 Å)
Cite:L-Asp is a useful tool in the purification of the ionotropic glutamate receptor A2 ligand-binding domain.
Febs J., 281, 2014
4O3C
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BU of 4o3c by Molmil
Crystal structure of the GLUA2 ligand-binding domain in complex with L-aspartate at 1.50 A resolution
Descriptor: ACETATE ION, ASPARTIC ACID, CHLORIDE ION, ...
Authors:Krintel, C, Frydenvang, K, Kaern, A.M, Gajhede, M, Kastrup, J.S.
Deposit date:2013-12-18
Release date:2014-04-16
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:L-Asp is a useful tool in the purification of the ionotropic glutamate receptor A2 ligand-binding domain.
Febs J., 281, 2014
4NWC
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BU of 4nwc by Molmil
Crystal structure of the GluK3 ligand-binding domain (S1S2) in complex with the agonist (2S,4R)-4-(3-Methoxy-3-oxopropyl)glutamic acid at 2.01 A resolution.
Descriptor: (2S,4R)-4-(3-Methoxy-3-oxopropyl) glutamic acid, CHLORIDE ION, Glutamate receptor ionotropic, ...
Authors:Larsen, A.P, Venskutonyte, R, Frydenvang, K, Gajhede, M, Kastrup, J.S.
Deposit date:2013-12-06
Release date:2014-08-06
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.012 Å)
Cite:Molecular Recognition of Two 2,4-syn-Functionalized (S)-Glutamate Analogues by the Kainate Receptor GluK3 Ligand Binding Domain.
Chemmedchem, 9, 2014
4PE5
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BU of 4pe5 by Molmil
Crystal Structure of GluN1a/GluN2B NMDA Receptor Ion Channel
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 4-[(1R,2S)-2-(4-benzylpiperidin-1-yl)-1-hydroxypropyl]phenol, ...
Authors:Karakas, E, Furukawa, H.
Deposit date:2014-04-22
Release date:2014-06-04
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (3.96 Å)
Cite:Crystal structure of a heterotetrameric NMDA receptor ion channel.
Science, 344, 2014
1Y1M
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BU of 1y1m by Molmil
Crystal structure of the NR1 ligand binding core in complex with cycloleucine
Descriptor: 1-AMINOCYCLOPENTANECARBOXYLIC ACID, Glutamate [NMDA] receptor subunit zeta 1
Authors:Inanobe, A, Gouaux, E.
Deposit date:2004-11-18
Release date:2005-07-12
Last modified:2017-07-26
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Mechanism of Partial Agonist Action at the NR1 Subunit of NMDA Receptors.
Neuron, 47, 2005
1Y1Z
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BU of 1y1z by Molmil
Crystal structure of the NR1 ligand binding core in complex with ACBC
Descriptor: 1-AMINOCYCLOBUTANECARBOXLIC ACID, Glutamate [NMDA] receptor subunit zeta 1
Authors:Inanobe, A, Gouaux, E.
Deposit date:2004-11-19
Release date:2005-07-12
Last modified:2017-07-26
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Mechanism of Partial Agonist Action at the NR1 Subunit of NMDA Receptors.
Neuron, 47, 2005
1Y20
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BU of 1y20 by Molmil
Crystal structure of the NR1 ligand-binding core in complex with ACPC
Descriptor: 1-AMINOCYCLOPROPANECARBOXYLIC ACID, Glutamate [NMDA] receptor subunit zeta 1
Authors:Inanobe, A, Gouaux, E.
Deposit date:2004-11-19
Release date:2005-07-12
Last modified:2017-07-26
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Mechanism of Partial Agonist Action at the NR1 Subunit of NMDA Receptors.
Neuron, 47, 2005
1YAE
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BU of 1yae by Molmil
Structure of the Kainate Receptor Subunit GluR6 Agonist Binding Domain Complexed with Domoic Acid
Descriptor: (2S,3S,4S)-2-CARBOXY-4-[(1Z,3E,5R)-5-CARBOXY-1-METHYL-1,3-HEXADIENYL]-3-PYRROLIDINEACETIC ACID, 2-acetamido-2-deoxy-beta-D-glucopyranose, Glutamate receptor, ...
Authors:Nanao, M.H, Green, T, Stern-Bach, Y, Heinemann, S.F, Choe, S.
Deposit date:2004-12-17
Release date:2005-02-01
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (3.11 Å)
Cite:Structure of the kainate receptor subunit GluR6 agonist-binding domain complexed with domoic acid.
Proc.Natl.Acad.Sci.USA, 102, 2005
1XHY
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BU of 1xhy by Molmil
X-ray structure of the Y702F mutant of the GluR2 ligand-binding core (S1S2J) in complex with kainate at 1.85 A resolution
Descriptor: 3-(CARBOXYMETHYL)-4-ISOPROPENYLPROLINE, Glutamate receptor, SULFATE ION
Authors:Frandsen, A, Pickering, D.S, Vestergaard, B, Kasper, C, Nielsen, B.B, Greenwood, J.R, Campiani, G, Gajhede, M, Schousboe, A, Kastrup, J.S.
Deposit date:2004-09-21
Release date:2005-03-22
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Tyr702 Is an Important Determinant of Agonist Binding and Domain Closure of the Ligand-Binding Core of GluR2.
Mol.Pharmacol., 67, 2005
1YCJ
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BU of 1ycj by Molmil
Crystal structure of the kainate receptor GluR5 ligand-binding core in complex with (S)-glutamate
Descriptor: GLUTAMIC ACID, Ionotropic glutamate receptor 5, SULFATE ION
Authors:Naur, P, Vestergaard, B, Skov, L.K, Egebjerg, J, Gajhede, M, Kastrup, J.S.
Deposit date:2004-12-22
Release date:2005-02-01
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Crystal structure of the kainate receptor GluR5 ligand-binding core in complex with (S)-glutamate
Febs Lett., 579, 2005
4NF5
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BU of 4nf5 by Molmil
Crystal structure of GluN1/GluN2A ligand-binding domain in complex with glycine and D-AP5
Descriptor: 5-phosphono-D-norvaline, GLYCEROL, GLYCINE, ...
Authors:Jespersen, A, Tajima, N, Furukawa, H.
Deposit date:2013-10-30
Release date:2014-03-12
Last modified:2017-08-09
Method:X-RAY DIFFRACTION (1.903 Å)
Cite:Structural Insights into Competitive Antagonism in NMDA Receptors.
Neuron, 81, 2014
2A5S
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BU of 2a5s by Molmil
Crystal Structure Of The NR2A Ligand Binding Core In Complex With Glutamate
Descriptor: GLUTAMIC ACID, N-methyl-D-aspartate receptor NMDAR2A subunit
Authors:Furukawa, H, Singh, S.K, Mancusso, R, Gouaux, E.
Deposit date:2005-06-30
Release date:2005-11-15
Last modified:2017-07-26
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Subunit arrangement and function in NMDA receptors
Nature, 438, 2005
2A5T
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BU of 2a5t by Molmil
Crystal Structure Of The NR1/NR2A ligand-binding cores complex
Descriptor: GLUTAMIC ACID, GLYCINE, N-methyl-D-aspartate receptor NMDAR1-4a subunit, ...
Authors:Furukawa, H, Singh, S.K, Mancusso, R, Gouaux, E.
Deposit date:2005-06-30
Release date:2005-11-15
Last modified:2017-07-26
Method:X-RAY DIFFRACTION (2 Å)
Cite:Subunit arrangement and function in NMDA receptors
Nature, 438, 2005
4QF9
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BU of 4qf9 by Molmil
Structure of GluK1 ligand-binding domain (S1S2) in complex with (S)-2-amino-4-(2,3-dioxo-1,2,3,4-tetrahydroquinoxalin-6-yl)butanoic acid at 2.28 A resolution
Descriptor: (2S)-2-amino-4-(2,3-dioxo-1,2,3,4-tetrahydroquinoxalin-6-yl)butanoic acid, ACETATE ION, CHLORIDE ION, ...
Authors:Kristensen, C.M, Frydenvang, K, Kastrup, J.S.
Deposit date:2014-05-20
Release date:2015-04-22
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.28 Å)
Cite:Binding Mode of an alpha-Amino Acid-Linked Quinoxaline-2,3-dione Analogue at Glutamate Receptor Subtype GluK1.
ACS Chem Neurosci, 6, 2015
2AL5
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BU of 2al5 by Molmil
Crystal structure of the GluR2 ligand binding core (S1S2J) in complex with fluoro-willardiine and aniracetam
Descriptor: 1-(4-METHOXYBENZOYL)-2-PYRROLIDINONE, 2-AMINO-3-(5-FLUORO-2,4-DIOXO-3,4-DIHYDRO-2H-PYRIMIDIN-1-YL)-PROPIONIC ACID, Glutamate receptor 2
Authors:Jin, R, Clark, S, Weeks, A.M, Dudman, J.T, Gouaux, E, Partin, K.M.
Deposit date:2005-08-04
Release date:2005-10-25
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Mechanism of positive allosteric modulators acting on AMPA receptors.
J.Neurosci., 25, 2005
2ANJ
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BU of 2anj by Molmil
Crystal Structure of the Glur2 Ligand Binding Core (S1S2J-Y450W) Mutant in Complex With the Partial Agonist Kainic Acid at 2.1 A Resolution
Descriptor: 3-(CARBOXYMETHYL)-4-ISOPROPENYLPROLINE, Glutamate receptor 2
Authors:Holm, M.M, Naur, P, Vestergaard, B, Geballe, M.T, Gajhede, M, Kastrup, J.S, Traynelis, S.F, Egebjerg, J.
Deposit date:2005-08-11
Release date:2005-08-30
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:A Binding Site Tyrosine Shapes Desensitization Kinetics and Agonist Potency at GluR2: a mutagenic, kinetic, and crystallographic study
J.Biol.Chem., 280, 2005
6FAZ
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BU of 6faz by Molmil
Crystal structure of the GluA2 ligand-binding domain (S1S2J) in complex with the positive allosteric modulator TDPAM01 at 1.4 A resolution.
Descriptor: 1,2-ETHANEDIOL, 6,6'-(Ethane-1,2-diyl)bis(4-methyl-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide), ACETATE ION, ...
Authors:Nielsen, L, Laulumaa, S, Kastrup, J.S.
Deposit date:2017-12-18
Release date:2018-11-21
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Enhancing Action of Positive Allosteric Modulators through the Design of Dimeric Compounds.
J. Med. Chem., 61, 2018
6F29
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BU of 6f29 by Molmil
Crystal structure of the kainate receptor GluK3 ligand binding domain in complex with (S)-1-[2-Amino-2-carboxyethyl]-5,7-dihydrothieno[3,4-d]pyrimidin-2,4(1H,3H)-dione at resolution 2.6A
Descriptor: (2~{S})-2-azanyl-3-[2,4-bis(oxidanylidene)-5,7-dihydrothieno[3,4-d]pyrimidin-1-yl]propanoic acid, CHLORIDE ION, Glutamate receptor ionotropic, ...
Authors:Venskutonyte, R, Frydenvang, K, Kastrup, J.S.
Deposit date:2017-11-23
Release date:2018-02-28
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:( S)-2-Amino-3-(5-methyl-3-hydroxyisoxazol-4-yl)propanoic Acid (AMPA) and Kainate Receptor Ligands: Further Exploration of Bioisosteric Replacements and Structural and Biological Investigation.
J. Med. Chem., 61, 2018
6F28
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BU of 6f28 by Molmil
Crystal structure of the kainate receptor GluK3 ligand binding domain in complex with (S)-1-[2'-Amino-2'-carboxyethyl]-6-methyl-5,7-dihydropyrrolo[3,4-d]pyrimidin-2,4(1H,3H)-dione at resolution 2.4A
Descriptor: (2~{S})-2-azanyl-3-[6-methyl-2,4-bis(oxidanylidene)-5,7-dihydropyrrolo[3,4-d]pyrimidin-1-yl]propanoic acid, CHLORIDE ION, Glutamate receptor ionotropic, ...
Authors:Venskutonyte, R, Frydenvang, K, Kastrup, J.S.
Deposit date:2017-11-23
Release date:2018-02-28
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:( S)-2-Amino-3-(5-methyl-3-hydroxyisoxazol-4-yl)propanoic Acid (AMPA) and Kainate Receptor Ligands: Further Exploration of Bioisosteric Replacements and Structural and Biological Investigation.
J. Med. Chem., 61, 2018
6FQI
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BU of 6fqi by Molmil
GluA2(flop) G724C ligand binding core dimer bound to L-Glutamate (Form B) at 2.91 Angstrom resolution
Descriptor: GLUTAMIC ACID, Glutamate receptor 2
Authors:Coombs, I.D, Soto, D, Gold, M.G, Farrant, M.F, Cull-Candy, S.G.
Deposit date:2018-02-14
Release date:2019-03-13
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.91001153 Å)
Cite:Homomeric GluA2(R) AMPA receptors can conduct when desensitized.
Nat Commun, 10, 2019
6FQK
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BU of 6fqk by Molmil
GluA2(flop) S729C ligand binding core dimer bound to ZK200775 at 1.98 Angstrom resolution
Descriptor: Glutamate receptor 2,Glutamate receptor 2, {[7-morpholin-4-yl-2,3-dioxo-6-(trifluoromethyl)-3,4-dihydroquinoxalin-1(2H)-yl]methyl}phosphonic acid
Authors:Coombs, I.D, Soto, D, Gold, M.G, Farrant, M.F, Cull-Candy, S.G.
Deposit date:2018-02-14
Release date:2019-03-13
Last modified:2019-10-02
Method:X-RAY DIFFRACTION (1.98010445 Å)
Cite:Homomeric GluA2(R) AMPA receptors can conduct when desensitized.
Nat Commun, 10, 2019
6FQJ
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GluA2(flop) G724C ligand binding core dimer bound to ZK200775 at 2.50 Angstrom resolution
Descriptor: Glutamate receptor 2,Glutamate receptor 2, {[7-morpholin-4-yl-2,3-dioxo-6-(trifluoromethyl)-3,4-dihydroquinoxalin-1(2H)-yl]methyl}phosphonic acid
Authors:Coombs, I.D, Soto, D, Gold, M.G, Farrant, M.F, Cull-Candy, S.G.
Deposit date:2018-02-14
Release date:2019-03-13
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.500017 Å)
Cite:Homomeric GluA2(R) AMPA receptors can conduct when desensitized.
Nat Commun, 10, 2019
6FQG
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BU of 6fqg by Molmil
GluA2(flop) G724C ligand binding core dimer bound to L-Glutamate (Form A) at 2.34 Angstrom resolution
Descriptor: GLUTAMIC ACID, Glutamate receptor 2
Authors:Coombs, I.D, Soto, D, Gold, M.G, Farrant, M.F, Cull-Candy, S.G.
Deposit date:2018-02-14
Release date:2019-03-13
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.34139085 Å)
Cite:X-ray structure of GluA2 flop G724C ligand binding core dimer bound to glutamate at 2.32 Angstroms resolution
To Be Published
6FQH
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GluA2(flop) S729C ligand binding core dimer bound to NBQX at 1.76 Angstrom resolution
Descriptor: 6-nitro-2,3-bis(oxidanylidene)-1,4-dihydrobenzo[f]quinoxaline-7-sulfonamide, Glutamate receptor 2,Glutamate receptor 2
Authors:Coombs, I.D, Soto, D, Gold, M.G, Farrant, M.F, Cull-Candy, S.G.
Deposit date:2018-02-14
Release date:2019-03-13
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.75940013 Å)
Cite:Homomeric GluA2(R) AMPA receptors can conduct when desensitized.
Nat Commun, 10, 2019

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