Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

6F28
DownloadVisualize
BU of 6f28 by Molmil
Crystal structure of the kainate receptor GluK3 ligand binding domain in complex with (S)-1-[2'-Amino-2'-carboxyethyl]-6-methyl-5,7-dihydropyrrolo[3,4-d]pyrimidin-2,4(1H,3H)-dione at resolution 2.4A
Descriptor: (2~{S})-2-azanyl-3-[6-methyl-2,4-bis(oxidanylidene)-5,7-dihydropyrrolo[3,4-d]pyrimidin-1-yl]propanoic acid, CHLORIDE ION, Glutamate receptor ionotropic, ...
Authors:Venskutonyte, R, Frydenvang, K, Kastrup, J.S.
Deposit date:2017-11-23
Release date:2018-02-28
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:( S)-2-Amino-3-(5-methyl-3-hydroxyisoxazol-4-yl)propanoic Acid (AMPA) and Kainate Receptor Ligands: Further Exploration of Bioisosteric Replacements and Structural and Biological Investigation.
J. Med. Chem., 61, 2018
5NIH
DownloadVisualize
BU of 5nih by Molmil
Crystal structure of the GluA2 ligand-binding domain (S1S2J) in complex with agonist LM-12b at 1.3 A resolution.
Descriptor: (3~{a}~{R},4~{S},6~{a}~{R})-1-methyl-4,5,6,6~{a}-tetrahydro-3~{a}~{H}-pyrrolo[3,4-c]pyrazole-3,4-dicarboxylic acid, ACETATE ION, CHLORIDE ION, ...
Authors:Laulumaa, S, Frydenvang, K.A, Kastrup, J.S.
Deposit date:2017-03-24
Release date:2017-07-26
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Structure and Affinity of Two Bicyclic Glutamate Analogues at AMPA and Kainate Receptors.
ACS Chem Neurosci, 8, 2017
5NEB
DownloadVisualize
BU of 5neb by Molmil
Structure of GluK1 ligand-binding domain (S1S2) in complex with LM-12b at 2.05 A resolution
Descriptor: (3~{a}~{R},4~{S},6~{a}~{R})-1-methyl-4,5,6,6~{a}-tetrahydro-3~{a}~{H}-pyrrolo[3,4-c]pyrazole-3,4-dicarboxylic acid, ACETATE ION, CHLORIDE ION, ...
Authors:Moellerud, S, Frydenvang, K, Laulumaa, S, Kastrup, J.S.
Deposit date:2017-03-10
Release date:2017-07-26
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Structure and Affinity of Two Bicyclic Glutamate Analogues at AMPA and Kainate Receptors.
ACS Chem Neurosci, 8, 2017
6IRG
DownloadVisualize
BU of 6irg by Molmil
Structure of the human GluN1/GluN2A NMDA receptor in the glutamate/glycine-bound state at pH 6.3, Class II
Descriptor: Glutamate receptor ionotropic, NMDA 1, NMDA 2A
Authors:Zhang, J, Chang, S, Zhang, X, Zhu, S.
Deposit date:2018-11-12
Release date:2019-01-16
Last modified:2019-06-05
Method:ELECTRON MICROSCOPY (5.5 Å)
Cite:Structural Basis of the Proton Sensitivity of Human GluN1-GluN2A NMDA Receptors
Cell Rep, 25, 2018
5NG9
DownloadVisualize
BU of 5ng9 by Molmil
Crystal structure of the GluA2 ligand-binding domain (S1S2J) in complex with agonist CIP-AS at 1.15 A resolution.
Descriptor: (2~{S},3~{R},4~{R})-3-(carboxycarbonyl)-4-oxidanyl-pyrrolidine-2-carboxylic acid, (3~{a}~{S},4~{S},6~{a}~{R})-4,5,6,6~{a}-tetrahydro-3~{a}~{H}-pyrrolo[3,4-d][1,2]oxazole-3,4-dicarboxylic acid, CITRATE ANION, ...
Authors:Laulumaa, S, Frydenvang, K.A, Winther, S, Kastrup, J.S.
Deposit date:2017-03-17
Release date:2017-07-26
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.15 Å)
Cite:Structure and Affinity of Two Bicyclic Glutamate Analogues at AMPA and Kainate Receptors.
ACS Chem Neurosci, 8, 2017
6FQH
DownloadVisualize
BU of 6fqh by Molmil
GluA2(flop) S729C ligand binding core dimer bound to NBQX at 1.76 Angstrom resolution
Descriptor: 6-nitro-2,3-bis(oxidanylidene)-1,4-dihydrobenzo[f]quinoxaline-7-sulfonamide, Glutamate receptor 2,Glutamate receptor 2
Authors:Coombs, I.D, Soto, D, Gold, M.G, Farrant, M.F, Cull-Candy, S.G.
Deposit date:2018-02-14
Release date:2019-03-13
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.75940013 Å)
Cite:Homomeric GluA2(R) AMPA receptors can conduct when desensitized.
Nat Commun, 10, 2019
6GL4
DownloadVisualize
BU of 6gl4 by Molmil
Structure of GluA2o ligand-binding domain (S1S2J) in complex with glutamate and sodium bromide at 1.95 A resolution
Descriptor: ACETATE ION, BROMIDE ION, GLUTAMIC ACID, ...
Authors:Venskutonyte, R, Frydenvang, K, Kastrup, J.S.
Deposit date:2018-05-22
Release date:2019-05-15
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.948 Å)
Cite:Nanoscale Mobility of the Apo State and TARP Stoichiometry Dictate the Gating Behavior of Alternatively Spliced AMPA Receptors.
Neuron, 102, 2019
5NF6
DownloadVisualize
BU of 5nf6 by Molmil
Structure of GluK3 ligand-binding domain (S1S2) in complex with CIP-AS at 2.55 A resolution
Descriptor: (3~{a}~{S},4~{S},6~{a}~{R})-4,5,6,6~{a}-tetrahydro-3~{a}~{H}-pyrrolo[3,4-d][1,2]oxazole-3,4-dicarboxylic acid, ACETATE ION, CHLORIDE ION, ...
Authors:Frydenvang, K, Venskutonyte, R, Thorsen, T.S, Kastrup, J.S.
Deposit date:2017-03-13
Release date:2017-07-26
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Structure and Affinity of Two Bicyclic Glutamate Analogues at AMPA and Kainate Receptors.
ACS Chem Neurosci, 8, 2017
7YFG
DownloadVisualize
BU of 7yfg by Molmil
Structure of the Rat GluN1-GluN2C NMDA receptor in complex with glycine and glutamate (major class in asymmetry)
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, GLUTAMIC ACID, ...
Authors:Zhang, M, Zhang, J, Guo, F, Li, Y, Zhu, S.
Deposit date:2022-07-08
Release date:2023-03-29
Last modified:2023-05-31
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Distinct structure and gating mechanism in diverse NMDA receptors with GluN2C and GluN2D subunits.
Nat.Struct.Mol.Biol., 30, 2023
7YFM
DownloadVisualize
BU of 7yfm by Molmil
Structure of GluN1b-GluN2D NMDA receptor in complex with agonists glycine and glutamate.
Descriptor: Glutamate receptor ionotropic, NMDA 2D, Isoform 6 of Glutamate receptor ionotropic, ...
Authors:Zhang, J.L, Zhu, S.J, Zhang, M.
Deposit date:2022-07-08
Release date:2023-03-29
Last modified:2023-08-02
Method:ELECTRON MICROSCOPY (5.1 Å)
Cite:Distinct structure and gating mechanism in diverse NMDA receptors with GluN2C and GluN2D subunits.
Nat.Struct.Mol.Biol., 30, 2023
3M3L
DownloadVisualize
BU of 3m3l by Molmil
PEPA bound to the ligand binding domain of GluA2 (flop form)
Descriptor: 2-[2,6-difluoro-4-({2-[(phenylsulfonyl)amino]ethyl}sulfanyl)phenoxy]acetamide, GLUTAMIC ACID, Glutamate receptor 2, ...
Authors:Ptak, C.P, Ahmed, A.H, Oswald, R.E.
Deposit date:2010-03-09
Release date:2010-03-23
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Molecular mechanism of flop selectivity and subsite recognition for an AMPA receptor allosteric modulator: structures of GluA2 and GluA3 in complexes with PEPA.
Biochemistry, 49, 2010
6FQI
DownloadVisualize
BU of 6fqi by Molmil
GluA2(flop) G724C ligand binding core dimer bound to L-Glutamate (Form B) at 2.91 Angstrom resolution
Descriptor: GLUTAMIC ACID, Glutamate receptor 2
Authors:Coombs, I.D, Soto, D, Gold, M.G, Farrant, M.F, Cull-Candy, S.G.
Deposit date:2018-02-14
Release date:2019-03-13
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.91001153 Å)
Cite:Homomeric GluA2(R) AMPA receptors can conduct when desensitized.
Nat Commun, 10, 2019
6CNA
DownloadVisualize
BU of 6cna by Molmil
GluN1-GluN2B NMDA receptors with exon 5
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Glutamate receptor ionotropic, ...
Authors:Furukawa, H, Grant, T, Grigorieff, N.
Deposit date:2018-03-07
Release date:2018-10-03
Last modified:2020-07-29
Method:ELECTRON MICROSCOPY (4.6 Å)
Cite:Structural Mechanism of Functional Modulation by Gene Splicing in NMDA Receptors.
Neuron, 98, 2018
3KGC
DownloadVisualize
BU of 3kgc by Molmil
Isolated ligand binding domain dimer of GluA2 ionotropic glutamate receptor in complex with glutamate, LY 404187 and ZK 200775
Descriptor: GLUTAMIC ACID, Glutamate receptor 2, N-[(2S)-2-(4'-cyanobiphenyl-4-yl)propyl]propane-2-sulfonamide, ...
Authors:Sobolevsky, A.I, Rosconi, M.P, Gouaux, E.
Deposit date:2009-10-28
Release date:2009-12-15
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:X-ray structure, symmetry and mechanism of an AMPA-subtype glutamate receptor
Nature, 462, 2009
6FQK
DownloadVisualize
BU of 6fqk by Molmil
GluA2(flop) S729C ligand binding core dimer bound to ZK200775 at 1.98 Angstrom resolution
Descriptor: Glutamate receptor 2,Glutamate receptor 2, {[7-morpholin-4-yl-2,3-dioxo-6-(trifluoromethyl)-3,4-dihydroquinoxalin-1(2H)-yl]methyl}phosphonic acid
Authors:Coombs, I.D, Soto, D, Gold, M.G, Farrant, M.F, Cull-Candy, S.G.
Deposit date:2018-02-14
Release date:2019-03-13
Last modified:2019-10-02
Method:X-RAY DIFFRACTION (1.98010445 Å)
Cite:Homomeric GluA2(R) AMPA receptors can conduct when desensitized.
Nat Commun, 10, 2019
6FQJ
DownloadVisualize
BU of 6fqj by Molmil
GluA2(flop) G724C ligand binding core dimer bound to ZK200775 at 2.50 Angstrom resolution
Descriptor: Glutamate receptor 2,Glutamate receptor 2, {[7-morpholin-4-yl-2,3-dioxo-6-(trifluoromethyl)-3,4-dihydroquinoxalin-1(2H)-yl]methyl}phosphonic acid
Authors:Coombs, I.D, Soto, D, Gold, M.G, Farrant, M.F, Cull-Candy, S.G.
Deposit date:2018-02-14
Release date:2019-03-13
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.500017 Å)
Cite:Homomeric GluA2(R) AMPA receptors can conduct when desensitized.
Nat Commun, 10, 2019
6FQG
DownloadVisualize
BU of 6fqg by Molmil
GluA2(flop) G724C ligand binding core dimer bound to L-Glutamate (Form A) at 2.34 Angstrom resolution
Descriptor: GLUTAMIC ACID, Glutamate receptor 2
Authors:Coombs, I.D, Soto, D, Gold, M.G, Farrant, M.F, Cull-Candy, S.G.
Deposit date:2018-02-14
Release date:2019-03-13
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.34139085 Å)
Cite:X-ray structure of GluA2 flop G724C ligand binding core dimer bound to glutamate at 2.32 Angstroms resolution
To Be Published
3M3F
DownloadVisualize
BU of 3m3f by Molmil
PEPA bound to the ligand binding domain of GluA3 (flop form)
Descriptor: 2-[2,6-difluoro-4-({2-[(phenylsulfonyl)amino]ethyl}sulfanyl)phenoxy]acetamide, GLUTAMIC ACID, Glutamate receptor 3, ...
Authors:Ahmed, A.H, Ptak, C.P, Oswald, R.E.
Deposit date:2010-03-09
Release date:2010-03-23
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Molecular mechanism of flop selectivity and subsite recognition for an AMPA receptor allosteric modulator: structures of GluA2 and GluA3 in complexes with PEPA.
Biochemistry, 49, 2010
5CBR
DownloadVisualize
BU of 5cbr by Molmil
Crystal structure of the GluA2 ligand-binding domain (S1S2J) in complex with the antagonist (S)-2-amino-3-(3,4-dichloro-5-(5-hydroxypyridin-3-yl)phenyl)propanoic acid at 2.0A resolution
Descriptor: 3,4-dichloro-5-(5-hydroxypyridin-3-yl)-L-phenylalanine, ACETATE ION, GLYCEROL, ...
Authors:Frydenvang, K, Kastrup, J.S.
Deposit date:2015-07-01
Release date:2015-12-30
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.996 Å)
Cite:Studies on Aryl-Substituted Phenylalanines: Synthesis, Activity, and Different Binding Modes at AMPA Receptors.
J.Med.Chem., 59, 2016
5CC2
DownloadVisualize
BU of 5cc2 by Molmil
STRUCTURE OF THE LIGAND-BINDING DOMAIN OF THE IONOTROPIC GLUTAMATE RECEPTOR-LIKE GLUD2 IN COMPLEX WITH 7-CKA
Descriptor: 7-Chlorokynurenic acid, CHLORIDE ION, GLYCEROL, ...
Authors:Naur, P, Gajhede, M, Kastrup, J.S.
Deposit date:2015-07-01
Release date:2015-12-30
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.501 Å)
Cite:Pharmacology and Structural Analysis of Ligand Binding to the Orthosteric Site of Glutamate-Like GluD2 Receptors.
Mol.Pharmacol., 89, 2016
5CBS
DownloadVisualize
BU of 5cbs by Molmil
Crystal structure of the GluA2 ligand-binding domain (S1S2J) in complex with the antagonist (R)-2-amino-3-(3'-hydroxybiphenyl-3-yl)propanoic acid at 1.8A resolution
Descriptor: (R)-2-amino-3-(3'-hydroxybiphenyl-3-yl)propanoic acid, 1,2-ETHANEDIOL, CHLORIDE ION, ...
Authors:Frydenvang, K, Kastrup, J.S.
Deposit date:2015-07-01
Release date:2015-12-30
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.801 Å)
Cite:Studies on Aryl-Substituted Phenylalanines: Synthesis, Activity, and Different Binding Modes at AMPA Receptors.
J.Med.Chem., 59, 2016
5CMK
DownloadVisualize
BU of 5cmk by Molmil
Crystal structure of the GluK2EM LBD dimer assembly complex with glutamate and LY466195
Descriptor: (3S,4aR,6S,8aR)-6-{[(2S)-2-carboxy-4,4-difluoropyrrolidin-1-yl]methyl}decahydroisoquinoline-3-carboxylic acid, CHLORIDE ION, GLUTAMIC ACID, ...
Authors:Chittori, S, Mayer, M.L.
Deposit date:2015-07-16
Release date:2016-07-20
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.801 Å)
Cite:Structural basis of kainate subtype glutamate receptor desensitization.
Nature, 537, 2016
5DT6
DownloadVisualize
BU of 5dt6 by Molmil
Crystal structure of the Drosophila GluR1A ligand binding domain complex with glutamate
Descriptor: GLUTAMIC ACID, GLYCEROL, Glutamate receptor 1
Authors:Dharkar, P, Mayer, M.L.
Deposit date:2015-09-17
Release date:2016-09-28
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.598 Å)
Cite:Novel Functional Properties of Drosophila CNS Glutamate Receptors.
Neuron, 92, 2016
5DTB
DownloadVisualize
BU of 5dtb by Molmil
Crystal structure of the Drosophila CG3822 KaiR1D ligand binding domain complex with glutamate
Descriptor: CG3822, GLUTAMIC ACID, GLYCEROL, ...
Authors:Dharkar, P, Mayer, M.L.
Deposit date:2015-09-17
Release date:2016-09-28
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.843 Å)
Cite:Novel Functional Properties of Drosophila CNS Glutamate Receptors.
Neuron, 92, 2016
5EHM
DownloadVisualize
BU of 5ehm by Molmil
Crystal structure of the Drosophila CG3822 KaiR1D ligand binding domain complex with NMDA
Descriptor: N-methyl-D-aspartic acid, RE06730p,CG3822
Authors:Dharkar, P, Mayer, M.L.
Deposit date:2015-10-28
Release date:2016-11-09
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (1.281 Å)
Cite:Novel Functional Properties of Drosophila CNS Glutamate Receptors.
Neuron, 92, 2016

221716

PDB entries from 2024-06-26

PDB statisticsPDBj update infoContact PDBjnumon