6XSR

Crystal structure of GluA2 AMPA receptor in complex with trans-4-butylcyclohexane carboxylic acid (4-BCCA) inhibitor

Summary for 6XSR

Entry DOI	10.2210/pdb6xsr/pdb
Descriptor	Glutamate receptor 2, 2-acetamido-2-deoxy-beta-D-glucopyranose, trans-4-butylcyclohexane-1-carboxylic acid (3 entities in total)
Functional Keywords	ampa receptor, ion channels, synapse, bcca, transport protein
Biological source	Rattus norvegicus (Rat)
Total number of polymer chains	4
Total formula weight	363862.82
Authors	Yelshanskaya, M.V.,Singh, A.K.,Sobolevsky, A.I. (deposition date: 2020-07-16, release date: 2020-12-30, Last modification date: 2023-10-18)
Primary citation	Yelshanskaya, M.V.,Singh, A.K.,Narangoda, C.,Williams, R.S.B.,Kurnikova, M.G.,Sobolevsky, A.I. Structural basis of AMPA receptor inhibition by trans-4-butylcyclohexane carboxylic acid. Br.J.Pharmacol., 179:3628-3644, 2022 Cited by PubMed: 32959886 DOI: 10.1111/bph.15254 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (4.25 Å)

Structure validation