7CX4
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![BU of 7cx4 by Molmil](/molmil-images/mine/7cx4) | Cryo-EM structure of the Evatanepag-bound EP2-Gs complex | Descriptor: | 2-[3-[[(4-~{tert}-butylphenyl)methyl-pyridin-3-ylsulfonyl-amino]methyl]phenoxy]ethanoic acid, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | Authors: | Qu, C, Mao, C, Xiao, P, Shen, Q, Zhong, Y, Yang, F, Shen, D, Tao, X, Zhang, H, Yan, X, Zhao, R, He, J, Guan, Y, Zhang, C, Hou, G, Zhang, P, Yu, X, Guan, Y, Sun, J, Zhang, Y. | Deposit date: | 2020-09-01 | Release date: | 2021-05-05 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | Ligand recognition, unconventional activation, and G protein coupling of the prostaglandin E 2 receptor EP2 subtype. Sci Adv, 7, 2021
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7CX3
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![BU of 7cx3 by Molmil](/molmil-images/mine/7cx3) | Cryo-EM structure of the Taprenepag-bound EP2-Gs complex | Descriptor: | 2-[3-[[(4-pyrazol-1-ylphenyl)methyl-pyridin-3-ylsulfonyl-amino]methyl]phenoxy]ethanoic acid, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | Authors: | Qu, C, Mao, C, Xiao, P, Shen, Q, Zhong, Y, Yang, F, Shen, D, Tao, X, Zhang, H, Yan, X, Zhao, R, He, J, Guan, Y, Zhang, C, Hou, G, Zhang, P, Yu, X, Guan, Y, Sun, J, Zhang, Y. | Deposit date: | 2020-09-01 | Release date: | 2021-05-05 | Method: | ELECTRON MICROSCOPY (2.8 Å) | Cite: | Ligand recognition, unconventional activation, and G protein coupling of the prostaglandin E 2 receptor EP2 subtype. Sci Adv, 7, 2021
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8OZ0
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![BU of 8oz0 by Molmil](/molmil-images/mine/8oz0) | Structure of a human 48S translation initiation complex with eIF4F and eIF4A | Descriptor: | 18S rRNA, 40S ribosomal protein S10, 40S ribosomal protein S11, ... | Authors: | Brito Querido, J, Sokabe, M, Diaz-Lopez, I, Gordiyenko, Y, Fraser, C.S, Ramakrishnan, V. | Deposit date: | 2023-05-06 | Release date: | 2024-02-07 | Last modified: | 2024-04-24 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | The structure of a human translation initiation complex reveals two independent roles for the helicase eIF4A. Nat.Struct.Mol.Biol., 31, 2024
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8P5Q
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7CX2
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![BU of 7cx2 by Molmil](/molmil-images/mine/7cx2) | Cryo-EM structure of the PGE2-bound EP2-Gs complex | Descriptor: | (Z)-7-[(1R,2R,3R)-3-hydroxy-2-[(E,3S)-3-hydroxyoct-1-enyl]-5-oxo-cyclopentyl]hept-5-enoic acid, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | Authors: | Qu, C, Mao, C, Xiao, P, Shen, Q, Zhong, Y, Yang, F, Shen, D, Tao, X, Zhang, H, Yan, X, Zhao, R, He, J, Guan, Y, Zhang, C, Hou, G, Zhang, P, Yu, X, Guan, Y, Sun, J, Zhang, Y. | Deposit date: | 2020-09-01 | Release date: | 2021-05-05 | Method: | ELECTRON MICROSCOPY (2.8 Å) | Cite: | Ligand recognition, unconventional activation, and G protein coupling of the prostaglandin E 2 receptor EP2 subtype. Sci Adv, 7, 2021
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8OZB
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![BU of 8ozb by Molmil](/molmil-images/mine/8ozb) | Crystal structure of Nup35-Nb complex | Descriptor: | Nucleoporin NUP35, Nup35 nanobody | Authors: | Srinivasan, V. | Deposit date: | 2023-05-08 | Release date: | 2024-02-28 | Last modified: | 2024-06-12 | Method: | X-RAY DIFFRACTION (2.09 Å) | Cite: | A checkpoint function for Nup98 in nuclear pore formation suggested by novel inhibitory nanobodies. Embo J., 43, 2024
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7A3O
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![BU of 7a3o by Molmil](/molmil-images/mine/7a3o) | Crystal structure of dengue 1 virus envelope glycoprotein in complex with the scFv fragment of the broadly neutralizing human antibody EDE1 C10 | Descriptor: | Core protein, GLYCEROL, SULFATE ION, ... | Authors: | Sharma, A, Vaney, M.C, Guardado-Calvo, P, Duquerroy, S, Rouvinski, A, Rey, F.A. | Deposit date: | 2020-08-18 | Release date: | 2021-12-08 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | The epitope arrangement on flavivirus particles contributes to Mab C10's extraordinary neutralization breadth across Zika and dengue viruses. Cell, 184, 2021
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7A3T
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![BU of 7a3t by Molmil](/molmil-images/mine/7a3t) | Crystal structure of dengue 3 virus envelope glycoprotein in complex with the Fab fragment of the broadly neutralizing human antibody EDE1 C8 | Descriptor: | Core protein, EDE1 C8 antibody Fab fragment, GLYCEROL, ... | Authors: | Sharma, A, Vaney, M.C, Guardado-Calvo, P, Duquerroy, S, Rouvinski, A, Rey, F.A. | Deposit date: | 2020-08-18 | Release date: | 2021-12-08 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.65 Å) | Cite: | The epitope arrangement on flavivirus particles contributes to Mab C10's extraordinary neutralization breadth across Zika and dengue viruses. Cell, 184, 2021
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6IBX
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![BU of 6ibx by Molmil](/molmil-images/mine/6ibx) | Human PFKFB3 in complex with a N-Aryl 6-Aminoquinoxaline inhibitor 5 | Descriptor: | 3-[[8-(1-methylindol-6-yl)quinoxalin-6-yl]amino]-~{N}-[(3~{S})-1-methylpiperidin-3-yl]pyridine-4-carboxamide, 6-O-phosphono-beta-D-fructofuranose, 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3, ... | Authors: | Banaszak, K, Pawlik, H, Bialas, A, Fabritius, C.H, Nowak, M. | Deposit date: | 2018-12-01 | Release date: | 2019-01-23 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.11 Å) | Cite: | Synthesis of amide and sulfonamide substituted N-aryl 6-aminoquinoxalines as PFKFB3 inhibitors with improved physicochemical properties. Bioorg. Med. Chem. Lett., 29, 2019
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8ONK
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8P1R
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![BU of 8p1r by Molmil](/molmil-images/mine/8p1r) | Bifidobacterium asteroides alpha-L-fucosidase (TT1819) catalytic mutant. | Descriptor: | 1,2-ETHANEDIOL, Bifidobacterium asteroides alpha-L-fucosidase (TT1819) catalytic mutant, MAGNESIUM ION | Authors: | Owen, C.D, Penner, M, Gascuena, A.N, Wu, H, Hernando, P.J, Monaco, S, Le Gall, G, Gardner, R, Ndeh, D, Urbanowicz, P.A, Spencer, D.I.R, Walsh, M.A, Angulo, J, Juge, N. | Deposit date: | 2023-05-12 | Release date: | 2024-03-27 | Method: | X-RAY DIFFRACTION (1.659 Å) | Cite: | Exploring sequence, structure and function of microbial fucosidases from glycoside hydrolase GH29 family To Be Published
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4WVG
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8OKF
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![BU of 8okf by Molmil](/molmil-images/mine/8okf) | WD repeat containing protein 5 (WDR5)- PER2 peptide | Descriptor: | CHLORIDE ION, Glutathione S-transferase class-mu 26 kDa isozyme,WD repeat domain 5, PENTAETHYLENE GLYCOL, ... | Authors: | Wolf, E, Boergel, A. | Deposit date: | 2023-03-28 | Release date: | 2024-04-10 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | A structural competition involving WDR5 times circadian oscillations To Be Published
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8PAY
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![BU of 8pay by Molmil](/molmil-images/mine/8pay) | Structure of the E.coli DNA polymerase sliding clamp with a covalently bound peptide 2. | Descriptor: | ACE-GLN-ALC-GLC-LEU-PHE, Beta sliding clamp, GLYCEROL, ... | Authors: | Compain, G, Monsarrat, C, Blagojevic, J, Brillet, K, Dumas, P, Hammann, P, Kuhn, L, Martiel, I, Engilberge, S, Olieric, V, Wolff, P, Burnouf, D, wagner, J, Guichard, G. | Deposit date: | 2023-06-08 | Release date: | 2024-03-13 | Method: | X-RAY DIFFRACTION (1.21 Å) | Cite: | Peptide-Based Covalent Inhibitors Bearing Mild Electrophiles to Target a Conserved His Residue of the Bacterial Sliding Clamp. Jacs Au, 4, 2024
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6Y5F
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![BU of 6y5f by Molmil](/molmil-images/mine/6y5f) | Crystal structure of the envelope glycoprotein prefusion complex of Andes virus - Mutant H953F | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Envelope polyprotein,Envelope polyprotein, PHOSPHATE ION, ... | Authors: | Serris, A, Rey, F.A, Guardado-Calvo, P. | Deposit date: | 2020-02-25 | Release date: | 2020-10-14 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | The Hantavirus Surface Glycoprotein Lattice and Its Fusion Control Mechanism. Cell, 183, 2020
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8P0M
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![BU of 8p0m by Molmil](/molmil-images/mine/8p0m) | Crystal structure of TEAD3 in complex with IAG933 | Descriptor: | 2-(2-{2-[2-(2-METHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHANOL, 4-[(2~{S})-5-chloranyl-6-fluoranyl-2-phenyl-2-[(2~{S})-pyrrolidin-2-yl]-3~{H}-1-benzofuran-4-yl]-5-fluoranyl-6-(2-hydroxyethyloxy)-~{N}-methyl-pyridine-3-carboxamide, DIMETHYL SULFOXIDE, ... | Authors: | Scheufler, C, Villard, F, Chau, S. | Deposit date: | 2023-05-10 | Release date: | 2024-04-10 | Last modified: | 2024-08-07 | Method: | X-RAY DIFFRACTION (1.961 Å) | Cite: | Direct and selective pharmacological disruption of the YAP-TEAD interface by IAG933 inhibits Hippo-dependent and RAS-MAPK-altered cancers. Nat Cancer, 5, 2024
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6Y5M
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![BU of 6y5m by Molmil](/molmil-images/mine/6y5m) | Crystal structure of mouse Autotaxin in complex with compound 1a | Descriptor: | (~{E})-3-[4-chloranyl-2-[(5-methyl-1,2,3,4-tetrazol-2-yl)methyl]phenyl]-1-[(2~{R})-4-[(4-fluorophenyl)methyl]-2-methyl-piperazin-1-yl]prop-2-en-1-one, 2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, ... | Authors: | Faller, M, Zink, F. | Deposit date: | 2020-02-25 | Release date: | 2020-11-18 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.011 Å) | Cite: | Development of autotaxin inhibitors: A series of tetrazole cinnamides. Bioorg.Med.Chem.Lett., 31, 2021
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8OT7
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7Z64
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![BU of 7z64 by Molmil](/molmil-images/mine/7z64) | A GH18 from haloalkaliphilic bacterium unveils environment-dependent variations in the catalytic machinery of chitinases | Descriptor: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Chitinase, ... | Authors: | Madhuprakash, J, Dalhus, B, Rohr, A.K, Bissaro, B, Vaaje-Kolstad, G, Sorlie, M, Eijsink, V.G. | Deposit date: | 2022-03-10 | Release date: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.31 Å) | Cite: | A GH18 from haloalkaliphilic bacterium unveils environment-dependent variations in the catalytic machinery of chitinases To Be Published
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5HVH
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![BU of 5hvh by Molmil](/molmil-images/mine/5hvh) | Crystal Structure of Thrombin-activatable Fibrinolysis Inhibitor in Complex with two Inhibitory Nanobodies | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Carboxypeptidase B2, ... | Authors: | Zhou, X, Weeks, S.D, Strelkov, S.V, Declerck, P.J. | Deposit date: | 2016-01-28 | Release date: | 2016-06-22 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Elucidation of the molecular mechanisms of two nanobodies that inhibit thrombin-activatable fibrinolysis inhibitor activation and activated thrombin-activatable fibrinolysis inhibitor activity. J.Thromb.Haemost., 14, 2016
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6Y9M
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![BU of 6y9m by Molmil](/molmil-images/mine/6y9m) | Crystal structure of TSWV glycoprotein N ectodomain (sGn) | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Glycoprotein, PHOSPHATE ION, ... | Authors: | Dessau, M, Bahat, Y. | Deposit date: | 2020-03-10 | Release date: | 2020-09-30 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (3.4 Å) | Cite: | Crystal structure of tomato spotted wilt virus G N reveals a dimer complex formation and evolutionary link to animal-infecting viruses Proc.Natl.Acad.Sci.USA, 117, 2020
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8OZ7
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8P2V
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![BU of 8p2v by Molmil](/molmil-images/mine/8p2v) | Neisseria meningitidis Type IV pilus SB-GATDH variant | Descriptor: | (2~{R})-~{N}-[(2~{R},3~{S},4~{S},5~{R},6~{R})-5-acetamido-2-methyl-4,6-bis(oxidanyl)oxan-3-yl]-2,3-bis(oxidanyl)propanamide, Neisseria meningitidis PilE variant SB-GATDH, SN-GLYCEROL-3-PHOSPHATE | Authors: | Fernandez-Martinez, D, Dumenil, G. | Deposit date: | 2023-05-16 | Release date: | 2024-04-03 | Method: | ELECTRON MICROSCOPY (2.99 Å) | Cite: | Cryo-EM structures of type IV pili complexed with nanobodies reveal immune escape mechanisms. Nat Commun, 15, 2024
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7NI3
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![BU of 7ni3 by Molmil](/molmil-images/mine/7ni3) | CRYSTAL STRUCTURE OF NATIVE HUMAN MYELOPEROXIDASE IN COMPLEX WITH CPD 3 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-sulfanylidene-3-[(2R)-tetrahydro-2-furanylmethyl]-1,2,3,7-tetrahydro-6H-purin-6-one, CALCIUM ION, ... | Authors: | Sjogren, T, Inghardt, T. | Deposit date: | 2021-02-11 | Release date: | 2022-02-23 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Discovery of AZD4831, a Mechanism-Based Irreversible Inhibitor of Myeloperoxidase, As a Potential Treatment for Heart Failure with Preserved Ejection Fraction. J.Med.Chem., 65, 2022
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8P6G
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![BU of 8p6g by Molmil](/molmil-images/mine/8p6g) | Crystal structure of the improved version of the Genetically Encoded Green Calcium Indicator YTnC2-5 | Descriptor: | DI(HYDROXYETHYL)ETHER, Genetically Encoded Green Calcium Indicator YTnC2-5 based on Troponin C from toadfish | Authors: | Boyko, K.M, Nikolaeva, A.Y, Subach, O.M, Vlaskina, A.V, Agapova, Y.K, Popov, V.O, Subach, F.V. | Deposit date: | 2023-05-26 | Release date: | 2024-04-03 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | YTnC2, an improved genetically encoded green calcium indicator based on toadfish troponin C. Febs Open Bio, 13, 2023
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