8P0M

Crystal structure of TEAD3 in complex with IAG933

Summary for 8P0M

Entry DOI	10.2210/pdb8p0m/pdb
Descriptor	Transcriptional enhancer factor TEF-5, 2-(2-{2-[2-(2-METHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHANOL, MYRISTIC ACID, ... (7 entities in total)
Functional Keywords	inhibitor, complex, transcription
Biological source	Homo sapiens (human) More
Total number of polymer chains	4
Total formula weight	105243.84
Authors	Scheufler, C.,Villard, F.,Chau, S. (deposition date: 2023-05-10, release date: 2024-04-10, Last modification date: 2024-04-17)
Primary citation	Chapeau, E.A.,Sansregret, L.,Galli, G.G.,Chene, P.,Wartmann, M.,Mourikis, T.P.,Jaaks, P.,Baltschukat, S.,Barbosa, I.A.M.,Bauer, D.,Brachmann, S.M.,Delaunay, C.,Estadieu, C.,Faris, J.E.,Furet, P.,Harlfinger, S.,Hueber, A.,Jimenez Nunez, E.,Kodack, D.P.,Mandon, E.,Martin, T.,Mesrouze, Y.,Romanet, V.,Scheufler, C.,Sellner, H.,Stamm, C.,Sterker, D.,Tordella, L.,Hofmann, F.,Soldermann, N.,Schmelzle, T. Direct and selective pharmacological disruption of the YAP-TEAD interface by IAG933 inhibits Hippo-dependent and RAS-MAPK-altered cancers. Nat Cancer, 2024 Cited by PubMed: 38565920 DOI: 10.1038/s43018-024-00754-9 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.961 Å)

Structure validation