8P0M
Crystal structure of TEAD3 in complex with IAG933
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Transcriptional enhancer factor TEF-5 | polymer | 222 | 25333.8 | 2 | UniProt (Q99594) Pfam (PF17725) | Homo sapiens (human) | DTEF-1,TEA domain family member 3,TEAD-3 |
| 2 | C, D (C, D) | Transcriptional enhancer factor TEF-5 | polymer | 222 | 25543.2 | 2 | Pfam (PF17725) UniProt (by SIFTS) (Q99594) | Homo sapiens | |
| 3 | E, H, M (A, B, D) | 2-(2-{2-[2-(2-METHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHANOL | non-polymer | 252.3 | 3 | Chemie (1PG) | |||
| 4 | F, I (A, B) | MYRISTIC ACID | non-polymer | 228.4 | 2 | Chemie (MYR) | |||
| 5 | G, J, L, O (A, B, C, D) | 4-[(2~{S})-5-chloranyl-6-fluoranyl-2-phenyl-2-[(2~{S})-pyrrolidin-2-yl]-3~{H}-1-benzofuran-4-yl]-5-fluoranyl-6-(2-hydroxyethyloxy)-~{N}-methyl-pyridine-3-carboxamide | non-polymer | 530.0 | 4 | Chemie (WCF) | |||
| 6 | K, N (C, D) | DIMETHYL SULFOXIDE | non-polymer | 78.1 | 2 | Chemie (DMS) | |||
| 7 | P, Q, R, S (A, B, C, D) | water | water | 18.0 | 352 | Chemie (HOH) |
Sequence modifications
A, B: 218 - 435 (UniProt: Q99594)
| PDB | External Database | Details |
|---|---|---|
| Gly 215 | - | expression tag |
| Pro 216 | - | expression tag |
| Gly 217 | - | expression tag |
| Gly 436 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 101754.1 | |
| Non-Polymers* | Number of molecules | 11 |
| Total formula weight | 3489.8 | |
| All* | Total formula weight | 105243.8 |
