7A3O

Crystal structure of dengue 1 virus envelope glycoprotein in complex with the scFv fragment of the broadly neutralizing human antibody EDE1 C10

Summary for 7A3O

Entry DOI	10.2210/pdb7a3o/pdb
Related	7A3N 7A3P 7A3Q 7A3R 7A3S 7A3T 7A3U 7CTH
Descriptor	Core protein, Single chain variable fragment (scFv) from antibody EDE1 C10, alpha-L-fucopyranose-(1-6)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (7 entities in total)
Functional Keywords	viral protein, flavivirus, class 2 fusion protein, dengue, antibody
Biological source	Dengue virus 1 More
Total number of polymer chains	3
Total formula weight	79425.11
Authors	Sharma, A.,Vaney, M.C.,Guardado-Calvo, P.,Duquerroy, S.,Rouvinski, A.,Rey, F.A. (deposition date: 2020-08-18, release date: 2021-12-08, Last modification date: 2024-01-31)
Primary citation	Sharma, A.,Zhang, X.,Dejnirattisai, W.,Dai, X.,Gong, D.,Wongwiwat, W.,Duquerroy, S.,Rouvinski, A.,Vaney, M.C.,Guardado-Calvo, P.,Haouz, A.,England, P.,Sun, R.,Zhou, Z.H.,Mongkolsapaya, J.,Screaton, G.R.,Rey, F.A. The epitope arrangement on flavivirus particles contributes to Mab C10's extraordinary neutralization breadth across Zika and dengue viruses. Cell, 184:6052-6066.e18, 2021 Cited by PubMed: 34852239 DOI: 10.1016/j.cell.2021.11.010 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.8 Å)

Structure validation