7A3O

Crystal structure of dengue 1 virus envelope glycoprotein in complex with the scFv fragment of the broadly neutralizing human antibody EDE1 C10

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Core protein	polymer	432	47077.3	1	UniProt (Q9II02) Pfam (PF00869) Pfam (PF02832) In PDB	Dengue virus 1	Envelope protein E,Flavivirin protease NS2B regulatory subunit,Flavivirin protease NS3 catalytic subunit,Genome polyprotein,Matrix protein,Non-structural protein 1,Non-structural protein 2A,Non-structural protein 2B,Non-structural protein 3,Non-structural protein 4A,Non-structural protein 4B,Peptide 2k,Peptide pr,Protein prM,RNA-directed RNA polymerase NS5,Serine protease NS3,Serine protease subunit NS2B,Small envelope protein M
2	H	Single chain variable fragment (scFv) from antibody EDE1 C10	polymer	144	15679.2	1		Homo sapiens (Human)
3	L	Single chain variable fragment (scFv) from antibody EDE1 C10	polymer	154	15632.8	1		Homo sapiens (Human)
4	B	alpha-L-fucopyranose-(1-6)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		367.3	1	In PDB GlyTouCan (G86851RC)
5	A	GLYCEROL	non-polymer		92.1	1	Chemie (GOL)
6	A, L	SULFATE ION	non-polymer		96.1	6	Chemie (SO4)
7		water	water		18.0	4	Chemie (HOH)

Sequence modifications

A: 1 - 395 (UniProt: Q9II02)

PDB	External Database	Details
Ala 396	-	expression tag
Ala 397	-	expression tag
Asp 398	-	expression tag
Asp 399	-	expression tag
Asp 400	-	expression tag
Asp 401	-	expression tag
Lys 402	-	expression tag
Ala 403	-	expression tag
Gly 404	-	expression tag
Trp 405	-	expression tag
Ser 406	-	expression tag
His 407	-	expression tag
Pro 408	-	expression tag
Gln 409	-	expression tag
Phe 410	-	expression tag
Glu 411	-	expression tag
Lys 412	-	expression tag
Gly 413	-	expression tag
Gly 414	-	expression tag
Gly 415	-	expression tag
Ser 416	-	expression tag
Gly 417	-	expression tag
Gly 418	-	expression tag
Gly 419	-	expression tag
Ser 420	-	expression tag
Gly 421	-	expression tag
Gly 422	-	expression tag
Gly 423	-	expression tag
Ser 424	-	expression tag
Trp 425	-	expression tag
Ser 426	-	expression tag
His 427	-	expression tag
Pro 428	-	expression tag
Gln 429	-	expression tag
Phe 430	-	expression tag
Glu 431	-	expression tag
Lys 432	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	78389.3
Branched	Number of molecules	1
	Total formula weight	367.3
Non-Polymers*	Number of molecules	7
	Total formula weight	668.5
All*	Total formula weight	79425.1

*Water molecules are not included.