3K82
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![BU of 3k82 by Molmil](/molmil-images/mine/3k82) | Crystal Structure of the third PDZ domain of PSD-95 | Descriptor: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Disks large homolog 4, GLYCEROL, ... | Authors: | Camara-Artigas, A, Gavira, J.A. | Deposit date: | 2009-10-13 | Release date: | 2010-04-07 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (1.4 Å) | Cite: | Novel conformational aspects of the third PDZ domain of the neuronal post-synaptic density-95 protein revealed from two 1.4A X-ray structures J.Struct.Biol., 170, 2010
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2O4L
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![BU of 2o4l by Molmil](/molmil-images/mine/2o4l) | Crystal Structure of HIV-1 Protease (Q7K, I50V) in Complex with Tipranavir | Descriptor: | CHLORIDE ION, GLYCEROL, N-(3-{(1R)-1-[(6R)-4-HYDROXY-2-OXO-6-PHENETHYL-6-PROPYL-5,6-DIHYDRO-2H-PYRAN-3-YL]PROPYL}PHENYL)-5-(TRIFLUOROMETHYL)-2-PYRIDINESULFONAMIDE, ... | Authors: | Armstrong, A.A, Muzammil, S, Jakalian, A, Bonneau, P.R, Schmelmer, V, Freire, E, Amzel, L.M. | Deposit date: | 2006-12-04 | Release date: | 2006-12-12 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.33 Å) | Cite: | Unique thermodynamic response of tipranavir to human immunodeficiency virus type 1 protease drug resistance mutations. J.Virol., 81, 2007
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2OFA
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![BU of 2ofa by Molmil](/molmil-images/mine/2ofa) | Crystal structure of apo AVR4 (R112L,C122S) | Descriptor: | Avidin-related protein 4/5, FORMIC ACID | Authors: | Livnah, O, Hayouka, R, Eisenberg-Domovich, Y. | Deposit date: | 2007-01-03 | Release date: | 2007-12-25 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Critical importance of loop conformation to avidin-enhanced hydrolysis of an active biotin ester. Acta Crystallogr.,Sect.D, 64, 2008
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6WZU
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![BU of 6wzu by Molmil](/molmil-images/mine/6wzu) | The crystal structure of Papain-Like Protease of SARS CoV-2 , P3221 space group | Descriptor: | CHLORIDE ION, GLYCEROL, Non-structural protein 3, ... | Authors: | Osipiuk, J, Tesar, C, Endres, M, Jedrzejczak, R, Joachimiak, A, Center for Structural Genomics of Infectious Diseases (CSGID) | Deposit date: | 2020-05-14 | Release date: | 2020-05-27 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.79 Å) | Cite: | Structure of papain-like protease from SARS-CoV-2 and its complexes with non-covalent inhibitors. Nat Commun, 12, 2021
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6WRH
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![BU of 6wrh by Molmil](/molmil-images/mine/6wrh) | The crystal structure of Papain-Like Protease of SARS CoV-2 , C111S mutant | Descriptor: | CHLORIDE ION, GLYCEROL, Non-structural protein 3, ... | Authors: | Osipiuk, J, Tesar, C, Jedrzejczak, R, Endres, M, Welk, L, Babnigg, G, Kim, Y, Michalska, K, Joachimiak, A, Center for Structural Genomics of Infectious Diseases (CSGID) | Deposit date: | 2020-04-29 | Release date: | 2020-05-06 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Structure of papain-like protease from SARS-CoV-2 and its complexes with non-covalent inhibitors. Nat Commun, 12, 2021
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7CKO
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![BU of 7cko by Molmil](/molmil-images/mine/7cko) | Cryo-EM structure of the human MCT1/Basigin-2 complex in the presence of anti-cancer drug candidate 7ACC2 in the inward-open conformation | Descriptor: | 7-[methyl-(phenylmethyl)amino]-2-oxidanylidene-chromene-3-carboxylic acid, Basigin, Monocarboxylate transporter 1 | Authors: | Wang, N, Jiang, X, Zhang, S, Zhu, A, Yuan, Y, Lei, J, Yan, C. | Deposit date: | 2020-07-18 | Release date: | 2020-12-23 | Last modified: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (2.95 Å) | Cite: | Structural basis of human monocarboxylate transporter 1 inhibition by anti-cancer drug candidates. Cell, 184, 2021
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6X59
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![BU of 6x59 by Molmil](/molmil-images/mine/6x59) | The mouse cGAS catalytic domain binding to human assembled nucleosome | Descriptor: | Cyclic GMP-AMP synthase, DNA, Histone H2A type 1, ... | Authors: | Pengbiao, X, Pingwei, L, Baoyu, Z. | Deposit date: | 2020-05-25 | Release date: | 2020-09-16 | Last modified: | 2024-05-15 | Method: | ELECTRON MICROSCOPY (2.98 Å) | Cite: | The molecular basis of tight nuclear tethering and inactivation of cGAS. Nature, 587, 2020
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7CJM
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![BU of 7cjm by Molmil](/molmil-images/mine/7cjm) | SARS CoV-2 PLpro in complex with GRL0617 | Descriptor: | 5-amino-2-methyl-N-[(1R)-1-naphthalen-1-ylethyl]benzamide, Non-structural protein 3, ZINC ION | Authors: | Fu, Z, Huang, H. | Deposit date: | 2020-07-11 | Release date: | 2020-09-02 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | The complex structure of GRL0617 and SARS-CoV-2 PLpro reveals a hot spot for antiviral drug discovery. Nat Commun, 12, 2021
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2PQA
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![BU of 2pqa by Molmil](/molmil-images/mine/2pqa) | Crystal Structure of Full-length Human RPA 14/32 Heterodimer | Descriptor: | Replication protein A 14 kDa subunit, Replication protein A 32 kDa subunit | Authors: | Deng, X, Borgstahl, G.E. | Deposit date: | 2007-05-01 | Release date: | 2007-11-13 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Structure of the full-length human RPA14/32 complex gives insights into the mechanism of DNA binding and complex formation. J.Mol.Biol., 374, 2007
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6VIE
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![BU of 6vie by Molmil](/molmil-images/mine/6vie) | Structure of caspase-1 in complex with gasdermin D | Descriptor: | Caspase-1 subunit p10, Caspase-1 subunit p20, Gasdermin-D | Authors: | Liu, Z, Xiao, T.S. | Deposit date: | 2020-01-13 | Release date: | 2020-07-01 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (3.4 Å) | Cite: | Caspase-1 Engages Full-Length Gasdermin D through Two Distinct Interfaces That Mediate Caspase Recruitment and Substrate Cleavage. Immunity, 53, 2020
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1YIQ
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![BU of 1yiq by Molmil](/molmil-images/mine/1yiq) | Molecular cloning and structural analysis of quinohemoprotein alcohol dehydrogenase ADHIIG from Pseudomonas putida HK5. Compariison to the other quinohemoprotein alcohol dehydrogenase ADHIIB found in the same microorganism. | Descriptor: | CALCIUM ION, HEME C, PYRROLOQUINOLINE QUINONE, ... | Authors: | Toyama, H, Chen, Z.W, Fukumoto, M, Adachi, O, Matsushita, K, Mathews, F.S. | Deposit date: | 2005-01-12 | Release date: | 2005-08-16 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Molecular cloning and structural analysis of quinohemoprotein alcohol dehydrogenase ADH-IIG from Pseudomonas putida HK5 J.Mol.Biol., 352, 2005
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5XV5
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![BU of 5xv5 by Molmil](/molmil-images/mine/5xv5) | Crystal structure of Rib7 mutant S88E from Methanosarcina mazei | Descriptor: | Conserved protein | Authors: | Yeh, T.M, Chen, S.C, Chang, T.H, Huang, M.F, Liaw, S.H. | Deposit date: | 2017-06-26 | Release date: | 2018-07-04 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Evolution of archaeal Rib7 and eubacterial RibG reductases in riboflavin biosynthesis: Substrate specificity and cofactor preference. Biochem. Biophys. Res. Commun., 503, 2018
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1ZEM
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![BU of 1zem by Molmil](/molmil-images/mine/1zem) | |
7CMN
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![BU of 7cmn by Molmil](/molmil-images/mine/7cmn) | |
2O4P
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![BU of 2o4p by Molmil](/molmil-images/mine/2o4p) | Crystal Structure of HIV-1 Protease (Q7K) in Complex with Tipranavir | Descriptor: | GLYCEROL, N-(3-{(1R)-1-[(6R)-4-HYDROXY-2-OXO-6-PHENETHYL-6-PROPYL-5,6-DIHYDRO-2H-PYRAN-3-YL]PROPYL}PHENYL)-5-(TRIFLUOROMETHYL)-2-PYRIDINESULFONAMIDE, protease | Authors: | Kang, L.W, Armstrong, A.A, Muzammil, S, Jakalian, A, Bonneau, P.R, Schmelmer, V, Freire, E, Amzel, L.M. | Deposit date: | 2006-12-04 | Release date: | 2006-12-12 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Unique thermodynamic response of tipranavir to human immunodeficiency virus type 1 protease drug resistance mutations. J.Virol., 81, 2007
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4OW0
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![BU of 4ow0 by Molmil](/molmil-images/mine/4ow0) | |
2OF8
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![BU of 2of8 by Molmil](/molmil-images/mine/2of8) | Crystal structure of AVR4 (D39A/C122S)-BNA complex | Descriptor: | 5-(2-OXO-HEXAHYDRO-THIENO[3,4-D]IMIDAZOL-6-YL)-PENTANOIC ACID (4-NITRO-PHENYL)-AMIDE, Avidin-related protein 4/5, FORMIC ACID | Authors: | Livnah, O, Hayouka, R, Eisenberg-Domovich, Y. | Deposit date: | 2007-01-03 | Release date: | 2007-12-25 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (1.05 Å) | Cite: | Critical importance of loop conformation to avidin-enhanced hydrolysis of an active biotin ester. Acta Crystallogr.,Sect.D, 64, 2008
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2OFB
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![BU of 2ofb by Molmil](/molmil-images/mine/2ofb) | Crystal structure of AVR4 (R112L/C122S)-BNA complex | Descriptor: | 5-(2-OXO-HEXAHYDRO-THIENO[3,4-D]IMIDAZOL-6-YL)-PENTANOIC ACID (4-NITRO-PHENYL)-AMIDE, Avidin-related protein 4/5, FORMIC ACID | Authors: | Livnah, O, Hayouka, R, Eisenberg-Domovich, Y. | Deposit date: | 2007-01-03 | Release date: | 2007-12-25 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (1.16 Å) | Cite: | Critical importance of loop conformation to avidin-enhanced hydrolysis of an active biotin ester. Acta Crystallogr.,Sect.D, 64, 2008
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4O67
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![BU of 4o67 by Molmil](/molmil-images/mine/4o67) | Human cyclic GMP-AMP synthase (cGAS) in complex with GAMP | Descriptor: | Cyclic GMP-AMP synthase, ZINC ION, cGAMP | Authors: | Zhang, X, Chen, Z, Zhang, X.W, Chen, Z.J. | Deposit date: | 2013-12-20 | Release date: | 2014-02-05 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.444 Å) | Cite: | The Cytosolic DNA Sensor cGAS Forms an Oligomeric Complex with DNA and Undergoes Switch-like Conformational Changes in the Activation Loop. Cell Rep, 6, 2014
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2PIC
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![BU of 2pic by Molmil](/molmil-images/mine/2pic) | |
4O68
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![BU of 4o68 by Molmil](/molmil-images/mine/4o68) | Structure of human cyclic GMP-AMP synthase (cGAS) | Descriptor: | Cyclic GMP-AMP synthase, ZINC ION | Authors: | Zhang, X, Chen, Z, Zhang, X.W, Chen, Z.J. | Deposit date: | 2013-12-20 | Release date: | 2014-02-05 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.436 Å) | Cite: | The Cytosolic DNA Sensor cGAS Forms an Oligomeric Complex with DNA and Undergoes Switch-like Conformational Changes in the Activation Loop. Cell Rep, 6, 2014
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4O69
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![BU of 4o69 by Molmil](/molmil-images/mine/4o69) | Human cyclic GMP-AMP synthase (cGAS) in complex with sulfate ion | Descriptor: | Cyclic GMP-AMP synthase, SULFATE ION, ZINC ION | Authors: | Zhang, X, Chen, Z, Zhang, X.W, Chen, Z.J. | Deposit date: | 2013-12-20 | Release date: | 2014-02-05 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.252 Å) | Cite: | The Cytosolic DNA Sensor cGAS Forms an Oligomeric Complex with DNA and Undergoes Switch-like Conformational Changes in the Activation Loop. Cell Rep, 6, 2014
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4O6A
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![BU of 4o6a by Molmil](/molmil-images/mine/4o6a) | Mouse cyclic GMP-AMP synthase (cGAS) in complex with DNA | Descriptor: | Cyclic GMP-AMP synthase, DNA1, DNA2, ... | Authors: | Zhang, X, Chen, Z, Zhang, X.W, Chen, Z.J. | Deposit date: | 2013-12-20 | Release date: | 2014-02-05 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.859 Å) | Cite: | The Cytosolic DNA Sensor cGAS Forms an Oligomeric Complex with DNA and Undergoes Switch-like Conformational Changes in the Activation Loop. Cell Rep, 6, 2014
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1ZUH
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![BU of 1zuh by Molmil](/molmil-images/mine/1zuh) | |
2PKC
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![BU of 2pkc by Molmil](/molmil-images/mine/2pkc) | CRYSTAL STRUCTURE OF CALCIUM-FREE PROTEINASE K AT 1.5 ANGSTROMS RESOLUTION | Descriptor: | PROTEINASE K, SODIUM ION | Authors: | Mueller, A, Hinrichs, W, Wolf, W.M, Saenger, W. | Deposit date: | 1993-06-04 | Release date: | 1994-01-31 | Last modified: | 2017-11-29 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Crystal structure of calcium-free proteinase K at 1.5-A resolution. J.Biol.Chem., 269, 1994
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