2O4L

Crystal Structure of HIV-1 Protease (Q7K, I50V) in Complex with Tipranavir

Summary for 2O4L

• Entry DOI: 10.2210/pdb2o4l/pdb
• Descriptor: protease, CHLORIDE ION, N-(3-{(1R)-1-[(6R)-4-HYDROXY-2-OXO-6-PHENETHYL-6-PROPYL-5,6-DIHYDRO-2H-PYRAN-3-YL]PROPYL}PHENYL)-5-(TRIFLUOROMETHYL)-2-PYRIDINESULFONAMIDE, ... (5 entities in total)
• Functional Keywords: protease, viral protein
• Biological source: Human immunodeficiency virus 1
• Cellular location: Gag-Pol polyprotein: Host cell membrane ; Lipid-anchor. Matrix protein p17: Virion membrane; Lipid- anchor . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion . Reverse transcriptase/ribonuclease H: Virion . Integrase: Virion : P03367
• Total number of polymer chains: 2
• Total formula weight: 22439.32

Authors

Armstrong, A.A.,Muzammil, S.,Jakalian, A.,Bonneau, P.R.,Schmelmer, V.,Freire, E.,Amzel, L.M. (deposition date: 2006-12-04, release date: 2006-12-12, Last modification date: 2023-08-30)

• Primary citation: Muzammil, S.,Armstrong, A.A.,Kang, L.W.,Jakalian, A.,Bonneau, P.R.,Schmelmer, V.,Amzel, L.M.,Freire, E.; Unique thermodynamic response of tipranavir to human immunodeficiency virus type 1 protease drug resistance mutations.; J.Virol., 81:5144-5154, 2007; PubMed: 17360759; DOI: 10.1128/JVI.02706-06

Experimental method

X-RAY DIFFRACTION (1.33 Å)