2O4L
Crystal Structure of HIV-1 Protease (Q7K, I50V) in Complex with Tipranavir
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | protease | polymer | 99 | 10790.8 | 2 | UniProt (P03367) Pfam (PF00077) UniProt (by SIFTS) (Q1G1C3) | Human immunodeficiency virus 1 | |
| 2 | C, F (A, B) | CHLORIDE ION | non-polymer | 35.5 | 2 | Chemie (CL) | |||
| 3 | D (A) | N-(3-{(1R)-1-[(6R)-4-HYDROXY-2-OXO-6-PHENETHYL-6-PROPYL-5,6-DIHYDRO-2H-PYRAN-3-YL]PROPYL}PHENYL)-5-(TRIFLUOROMETHYL)-2-PYRIDINESULFONAMIDE | non-polymer | 602.7 | 1 | Chemie (TPV) | |||
| 4 | E, G (A, B) | GLYCEROL | non-polymer | 92.1 | 2 | Chemie (GOL) | |||
| 5 | H, I (A, B) | water | water | 18.0 | 380 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 99 (UniProt: P03367)
| PDB | External Database | Details |
|---|---|---|
| Lys 7 | Gln 506 | engineered mutation |
| Val 50 | Ile 549 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 21581.6 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 857.8 | |
| All* | Total formula weight | 22439.3 |
