4AE0
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6R72
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![BU of 6r72 by Molmil](/molmil-images/mine/6r72) | Crystal structure of BmrA-E504A in an outward-facing conformation | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Multidrug exporter ATP-binding cassette | Authors: | Chaptal, V, Zampieri, V, Kilburg, A, Magnard, S, Falson, P. | Deposit date: | 2019-03-28 | Release date: | 2020-05-06 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (3.95 Å) | Cite: | Substrate-bound and substrate-free outward-facing structures of a multidrug ABC exporter. Sci Adv, 8, 2022
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2LF1
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![BU of 2lf1 by Molmil](/molmil-images/mine/2lf1) | Solution structure of L. casei dihydrofolate reductase complexed with NADPH, 30 structures | Descriptor: | Dihydrofolate reductase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | Authors: | Polshakov, V, Feeney, J, Birdsall, B, Kovalevskaya, N. | Deposit date: | 2011-06-28 | Release date: | 2011-12-21 | Last modified: | 2024-05-01 | Method: | SOLUTION NMR | Cite: | NMR structures of apo L. casei dihydrofolate reductase and its complexes with trimethoprim and NADPH: contributions to positive cooperative binding from ligand-induced refolding, conformational changes, and interligand hydrophobic interactions Biochemistry, 50, 2011
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8DS8
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6U7T
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![BU of 6u7t by Molmil](/molmil-images/mine/6u7t) | MutY adenine glycosylase bound to DNA containing a transition state analog (1N) paired with d(8-oxo-G) | Descriptor: | Adenine DNA glycosylase, CALCIUM ION, DNA (5'-D(*AP*AP*GP*AP*CP*(8OG)P*TP*GP*GP*AP*C)-3'), ... | Authors: | O'Shea Murray, V.L, Cao, S, Horvath, M.P, David, S.S. | Deposit date: | 2019-09-03 | Release date: | 2019-10-02 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structural Basis for Finding OG Lesions and Avoiding Undamaged G by the DNA Glycosylase MutY. Acs Chem.Biol., 15, 2020
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6R2W
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![BU of 6r2w by Molmil](/molmil-images/mine/6r2w) | Crystal structure of the super-active FVIIa variant VYT in complex with tissue factor | Descriptor: | CALCIUM ION, Coagulation factor VII, N-acetyl-D-phenylalanyl-N-[(2S,3S)-6-carbamimidamido-1-chloro-2-hydroxyhexan-3-yl]-L-phenylalaninamide, ... | Authors: | Sorensen, A.B, Svensson, L.A, Gandhi, P.S. | Deposit date: | 2019-03-19 | Release date: | 2019-12-11 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.25 Å) | Cite: | Beating tissue factor at its own game: Design and properties of a soluble tissue factor-independent coagulation factor VIIa. J.Biol.Chem., 295, 2020
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6R5K
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6TZK
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![BU of 6tzk by Molmil](/molmil-images/mine/6tzk) | Bacterial cellulose synthase outermembrane channel BcsC with terminal TPR repeat | Descriptor: | (HYDROXYETHYLOXY)TRI(ETHYLOXY)OCTANE, 1,2-Distearoyl-sn-glycerophosphoethanolamine, 3,6,9,12,15,18,21,24-OCTAOXAHEXACOSAN-1-OL, ... | Authors: | Acheson, J.F, Derewenda, Z, Zimmer, J. | Deposit date: | 2019-08-12 | Release date: | 2019-10-23 | Last modified: | 2023-02-15 | Method: | X-RAY DIFFRACTION (1.852 Å) | Cite: | Architecture of the Cellulose Synthase Outer Membrane Channel and Its Association with the Periplasmic TPR Domain. Structure, 27, 2019
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6R6V
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![BU of 6r6v by Molmil](/molmil-images/mine/6r6v) | Structure of recombinant human butyrylcholinesterase in complex with a fluorescent coumarin-based probe | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Cholinesterase, ... | Authors: | Brazzolotto, X, Nachon, F, Knez, D, Gobec, S. | Deposit date: | 2019-03-28 | Release date: | 2020-01-15 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Development of potent reversible selective inhibitors of butyrylcholinesterase as fluorescent probes. J Enzyme Inhib Med Chem, 35, 2020
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2LS4
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6UC3
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![BU of 6uc3 by Molmil](/molmil-images/mine/6uc3) | Spectroscopic and structural characterization of a genetically encoded direct sensor for protein-ligand interactions | Descriptor: | BIOTIN, Streptavidin | Authors: | Mills, J.H, Gleason, P.R, Simmons, C.R, Henderson, J.N, Kartchner, B.K. | Deposit date: | 2019-09-13 | Release date: | 2020-09-16 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (1.84 Å) | Cite: | Structural Origins of Altered Spectroscopic Properties upon Ligand Binding in Proteins Containing a Fluorescent Noncanonical Amino Acid. Biochemistry, 60, 2021
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8DWF
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![BU of 8dwf by Molmil](/molmil-images/mine/8dwf) | Glycosylase MutY variant E43S in complex with DNA containing d(8-oxo-G) paired with substrate adenine | Descriptor: | 1,2-ETHANEDIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Adenine DNA glycosylase, ... | Authors: | Russelburg, L.P, Demir, M, David, S.S, Horvath, M.P. | Deposit date: | 2022-08-01 | Release date: | 2023-08-09 | Last modified: | 2024-05-22 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Structural Basis for Base Engagement and Stereochemistry Revealed by Alteration of Catalytic Residue Glu43 in DNA Repair Glycosylase MutY To Be Published
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8DWD
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![BU of 8dwd by Molmil](/molmil-images/mine/8dwd) | Adenine glycosylase MutY variant E43S in complex with DNA containing d(8-oxo-G) paired with an AP site generated by the enzyme acting on purine | Descriptor: | ACETATE ION, Adenine DNA glycosylase, CALCIUM ION, ... | Authors: | Russelburg, L.P, Demir, M, David, S.S, Horvath, M.P. | Deposit date: | 2022-08-01 | Release date: | 2023-08-09 | Last modified: | 2024-05-22 | Method: | X-RAY DIFFRACTION (1.68 Å) | Cite: | Structural Basis for Base Engagement and Stereochemistry Revealed by Alteration of Catalytic Residue Glu43 in DNA Repair Glycosylase MutY To Be Published
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2LOU
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![BU of 2lou by Molmil](/molmil-images/mine/2lou) | AR55 solubilised in DPC micelles | Descriptor: | Apelin receptor | Authors: | Langelaan, D.N, Rainey, J.K. | Deposit date: | 2012-01-27 | Release date: | 2013-01-16 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Structural features of the apelin receptor N-terminal tail and first transmembrane segment implicated in ligand binding and receptor trafficking. Biochim.Biophys.Acta, 1828, 2013
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6R81
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![BU of 6r81 by Molmil](/molmil-images/mine/6r81) | Multidrug resistance transporter BmrA mutant E504A bound with ATP and Mg solved by Cryo-EM | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, Lipid A export ATP-binding/permease protein MsbA, MAGNESIUM ION | Authors: | Wiseman, B, Chaptal, V, Zampieri, V, Magnard, S, Hogbom, M, Falson, P. | Deposit date: | 2019-03-30 | Release date: | 2020-05-06 | Last modified: | 2024-07-10 | Method: | ELECTRON MICROSCOPY (3.9 Å) | Cite: | Substrate-bound and substrate-free outward-facing structures of a multidrug ABC exporter. Sci Adv, 8, 2022
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8DWE
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![BU of 8dwe by Molmil](/molmil-images/mine/8dwe) | Adenine glycosylase MutY variant E43Q in complex with DNA containing d(8-oxo-G) paired with substrate purine | Descriptor: | 1,2-ETHANEDIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Adenine DNA glycosylase, ... | Authors: | Russelburg, L.P, Demir, M, David, S.S, Horvath, M.P. | Deposit date: | 2022-08-01 | Release date: | 2023-08-09 | Last modified: | 2024-05-22 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Structural Basis for Base Engagement and Stereochemistry Revealed by Alteration of Catalytic Residue Glu43 in DNA Repair Glycosylase MutY To Be Published
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6U3G
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6R7X
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![BU of 6r7x by Molmil](/molmil-images/mine/6r7x) | CryoEM structure of calcium-bound human TMEM16K / Anoctamin 10 in detergent (2mM Ca2+, closed form) | Descriptor: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, Anoctamin-10, CALCIUM ION, ... | Authors: | Pike, A.C.W, Bushell, S.R, Shintre, C.A, Tessitore, A, Baronina, A, Chu, A, Mukhopadhyay, S, Shrestha, L, Chalk, R, Burgess-Brown, N.A, Love, J, Huiskonen, J.T, Edwards, A.M, Arrowsmith, C.H, Bountra, C, Carpenter, E.P, Structural Genomics Consortium (SGC) | Deposit date: | 2019-03-29 | Release date: | 2019-05-01 | Last modified: | 2024-05-22 | Method: | ELECTRON MICROSCOPY (3.47 Å) | Cite: | The structural basis of lipid scrambling and inactivation in the endoplasmic reticulum scramblase TMEM16K. Nat Commun, 10, 2019
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2L7C
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![BU of 2l7c by Molmil](/molmil-images/mine/2l7c) | Biophysical studies of lipid interacting regions of DGD2 in Arabidopsis thaliana | Descriptor: | Digalactosyldiacylglycerol synthase 2, chloroplastic | Authors: | Szpryngiel, S, Ge, C, Iakovleva, I, Lind, J, Wieslander, A, Maler, L. | Deposit date: | 2010-12-07 | Release date: | 2011-10-19 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | Lipid interacting regions in phosphate stress glycosyltransferase atDGD2 from Arabidopsis thaliana. Biochemistry, 50, 2011
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2LAJ
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![BU of 2laj by Molmil](/molmil-images/mine/2laj) | Third WW domain of human Nedd4L in complex with doubly phosphorylated human smad3 derived peptide | Descriptor: | E3 ubiquitin-protein ligase NEDD4-like, Mothers against decapentaplegic homolog 3 | Authors: | Macias, M.J, Aragon, E, Goerner, N, Zaromytidou, A, Xi, Q, Escobedo, A, Massague, J. | Deposit date: | 2011-03-16 | Release date: | 2011-07-06 | Last modified: | 2023-06-14 | Method: | SOLUTION NMR | Cite: | A Smad action turnover switch operated by WW domain readers of a phosphoserine code. Genes Dev., 25, 2011
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4ATE
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![BU of 4ate by Molmil](/molmil-images/mine/4ate) | High resolution crystal structure of beta-porphyranase A from Zobellia galactanivorans | Descriptor: | BETA-PORPHYRANASE A, CALCIUM ION, CHLORIDE ION, ... | Authors: | Hehemann, J.H, Correc, G, Jam, M, Michel, G, Czjzek, M. | Deposit date: | 2012-05-06 | Release date: | 2012-07-25 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (1.1 Å) | Cite: | Biochemical and Structural Characterization of the Complex Agarolytic Enzyme System from the Marine Bacterium Zobellia Galactanivorans. J.Biol.Chem., 287, 2012
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6UIU
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![BU of 6uiu by Molmil](/molmil-images/mine/6uiu) | Artificial Iron Proteins: Modelling the Active Sites in Non-Heme Dioxygenases | Descriptor: | N-(2-{bis[(pyridin-2-yl)methyl]amino}ethyl)-5-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanamide, Streptavidin | Authors: | Miller, K.R, Paretsky, J.D, Follmer, A.H, Heinisch, T, Mittra, K, Gul, S, Kim, I.-S, Fuller, F.D, Batyuk, A, Sutherlin, K.D, Brewster, A.S, Bhowmick, A, Sauter, N.K, Kern, J, Yano, J, Green, M.T, Ward, T.R, Borovik, A.S. | Deposit date: | 2019-10-01 | Release date: | 2020-05-06 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.35 Å) | Cite: | Artificial Iron Proteins: Modeling the Active Sites in Non-Heme Dioxygenases. Inorg.Chem., 59, 2020
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4B9B
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![BU of 4b9b by Molmil](/molmil-images/mine/4b9b) | The structure of the omega aminotransferase from Pseudomonas aeruginosa | Descriptor: | BETA-ALANINE-PYRUVATE TRANSAMINASE, CALCIUM ION, CHLORIDE ION, ... | Authors: | Sayer, C, Isupov, M.N, Westlake, A, Littlechild, J.A. | Deposit date: | 2012-09-03 | Release date: | 2013-03-27 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (1.64 Å) | Cite: | Structural Studies with Pseudomonas and Chromobacterium [Omega]-Aminotransferases Provide Insights Into Their Differing Substrate Specificity. Acta Crystallogr.,Sect.D, 69, 2013
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6UKJ
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![BU of 6ukj by Molmil](/molmil-images/mine/6ukj) | Single-Particle Cryo-EM Structure of Plasmodium falciparum Chloroquine Resistance Transporter (PfCRT) 7G8 Isoform | Descriptor: | CHOLESTEROL HEMISUCCINATE, Chloroquine resistance transporter, Fab Heavy Chain, ... | Authors: | Kim, J, Tan, Y.Z, Wicht, K.J, Erramilli, S.K, Dhingra, S.K, Okombo, J, Vendome, J, Hagenah, L.M, Giacometti, S.I, Warren, A.L, Nosol, K, Roepe, P.D, Potter, C.S, Carragher, B, Kossiakoff, A.A, Quick, M, Fidock, D.A, Mancia, F. | Deposit date: | 2019-10-05 | Release date: | 2019-12-04 | Last modified: | 2020-01-08 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Structure and drug resistance of the Plasmodium falciparum transporter PfCRT. Nature, 576, 2019
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2LA8
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