6R81

Multidrug resistance transporter BmrA mutant E504A bound with ATP and Mg solved by Cryo-EM

Summary for 6R81

• Entry DOI: 10.2210/pdb6r81/pdb
• Related: 6R72
• EMDB information: 4749
• Descriptor: Lipid A export ATP-binding/permease protein MsbA, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION (3 entities in total)
• Functional Keywords: membrane protein, abc transporter, multidrug resistance, transport protein
• Biological source: Bacillus subtilis
• Total number of polymer chains: 2
• Total formula weight: 132557.25

Authors

Wiseman, B.,Chaptal, V.,Zampieri, V.,Magnard, S.,Hogbom, M.,Falson, P. (deposition date: 2019-03-30, release date: 2020-05-06, Last modification date: 2022-02-02)

• Primary citation: Chaptal, V.,Zampieri, V.,Wiseman, B.,Orelle, C.,Martin, J.,Nguyen, K.A.,Gobet, A.,Di Cesare, M.,Magnard, S.,Javed, W.,Eid, J.,Kilburg, A.,Peuchmaur, M.,Marcoux, J.,Monticelli, L.,Hogbom, M.,Schoehn, G.,Jault, J.M.,Boumendjel, A.,Falson, P.; Substrate-bound and substrate-free outward-facing structures of a multidrug ABC exporter.; Sci Adv, 8:eabg9215-eabg9215, 2022; PubMed: 35080979; DOI: 10.1126/sciadv.abg9215

Experimental method

ELECTRON MICROSCOPY (3.9 Å)