6UKJ

Single-Particle Cryo-EM Structure of Plasmodium falciparum Chloroquine Resistance Transporter (PfCRT) 7G8 Isoform

Summary for 6UKJ

Entry DOI	10.2210/pdb6ukj/pdb
EMDB information	20806
Descriptor	Chloroquine resistance transporter, Fab Heavy Chain, Fab Light Chain, ... (4 entities in total)
Functional Keywords	transporter, drug resistance, digestive vacuole of malaria parasite, nanodisc, membrane protein
Biological source	Plasmodium falciparum (isolate 7G8) More
Total number of polymer chains	3
Total formula weight	102654.72
Authors	Kim, J.,Tan, Y.Z.,Wicht, K.J.,Erramilli, S.K.,Dhingra, S.K.,Okombo, J.,Vendome, J.,Hagenah, L.M.,Giacometti, S.I.,Warren, A.L.,Nosol, K.,Roepe, P.D.,Potter, C.S.,Carragher, B.,Kossiakoff, A.A.,Quick, M.,Fidock, D.A.,Mancia, F. (deposition date: 2019-10-05, release date: 2019-12-04, Last modification date: 2020-01-08)
Primary citation	Kim, J.,Tan, Y.Z.,Wicht, K.J.,Erramilli, S.K.,Dhingra, S.K.,Okombo, J.,Vendome, J.,Hagenah, L.M.,Giacometti, S.I.,Warren, A.L.,Nosol, K.,Roepe, P.D.,Potter, C.S.,Carragher, B.,Kossiakoff, A.A.,Quick, M.,Fidock, D.A.,Mancia, F. Structure and drug resistance of the Plasmodium falciparum transporter PfCRT. Nature, 576:315-320, 2019 Cited by PubMed: 31776516 DOI: 10.1038/s41586-019-1795-x PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.3 Å)

Structure validation