6UKJ

Single-Particle Cryo-EM Structure of Plasmodium falciparum Chloroquine Resistance Transporter (PfCRT) 7G8 Isoform

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Chloroquine resistance transporter	polymer	464	53074.5	1	UniProt (W7FI62)	Plasmodium falciparum (isolate 7G8)
2	B (H)	Fab Heavy Chain	polymer	241	25737.6	1		Homo sapiens (Human)
3	C (L)	Fab Light Chain	polymer	215	23355.9	1		Homo sapiens (Human)
4	D (A)	CHOLESTEROL HEMISUCCINATE	non-polymer		486.7	1	Chemie (Y01)

Sequence modifications

A: 2 - 424 (UniProt: W7FI62)

PDB	External Database	Details
Met -2	-	initiating methionine
Gly -1	-	expression tag
Arg 0	-	expression tag
Ala 1	-	expression tag
Ala 425	-	expression tag
Ala 426	-	expression tag
Ala 427	-	expression tag
Gly 428	-	expression tag
Gly 429	-	expression tag
Gly 430	-	expression tag
Ser 431	-	expression tag
Gly 432	-	expression tag
Gly 433	-	expression tag
Gly 434	-	expression tag
Ser 435	-	expression tag
Glu 436	-	expression tag
Asn 437	-	expression tag
Leu 438	-	expression tag
Tyr 439	-	expression tag
Phe 440	-	expression tag
Gln 441	-	expression tag
Gly 442	-	expression tag
Ser 443	-	expression tag
His 444	-	expression tag
His 445	-	expression tag
His 446	-	expression tag
His 447	-	expression tag
His 448	-	expression tag
His 449	-	expression tag
His 450	-	expression tag
His 451	-	expression tag
His 452	-	expression tag
His 453	-	expression tag
Trp 454	-	expression tag
Ser 455	-	expression tag
His 456	-	expression tag
Pro 457	-	expression tag
Gln 458	-	expression tag
Phe 459	-	expression tag
Glu 460	-	expression tag
Lys 461	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	102168.0
Non-Polymers*	Number of molecules	1
	Total formula weight	486.7
All*	Total formula weight	102654.7

*Water molecules are not included.