6R2W

Crystal structure of the super-active FVIIa variant VYT in complex with tissue factor

Summary for 6R2W

DescriptorCoagulation factor VII, Tissue factor, CALCIUM ION, ... (10 entities in total)
Functional Keywordstrypsin-fold, protein-protein complex, hydrolase, coagulation factor
Biological sourceHomo sapiens (Human)
Total number of polymer chains3
Total molecular weight70055.74
Authors
Sorensen, A.B.,Svensson, L.A.,Gandhi, P.S. (deposition date: 2019-03-19, release date: 2019-12-11, Last modification date: 2020-01-22)
Primary citation
Sorensen, A.B.,Tuneew, I.,Svensson, L.A.,Persson, E.,Ostergaard, H.,Overgaard, M.T.,Olsen, O.H.,Gandhi, P.S.
Beating tissue factor at its own game: Design and properties of a soluble tissue factor-independent coagulation factor VIIa.
J.Biol.Chem., 295:517-528, 2020
PubMed: 31801825 (PDB entries with the same primary citation)
DOI: 10.1074/jbc.RA119.009183
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (1.25 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.19460 0.4% 5.9%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
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