6R2W

Crystal structure of the super-active FVIIa variant VYT in complex with tissue factor

Summary for 6R2W

• Entry DOI: 10.2210/pdb6r2w/pdb
• Descriptor: Coagulation factor VII, Tissue factor, alpha-D-xylopyranose-(1-3)-alpha-D-xylopyranose-(1-3)-beta-D-glucopyranose, ... (9 entities in total)
• Functional Keywords: trypsin-fold, protein-protein complex, hydrolase, coagulation factor
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 3
• Total formula weight: 70019.71

Authors

Sorensen, A.B.,Svensson, L.A.,Gandhi, P.S. (deposition date: 2019-03-19, release date: 2019-12-11, Last modification date: 2024-01-24)

• Primary citation: Sorensen, A.B.,Tuneew, I.,Svensson, L.A.,Persson, E.,Ostergaard, H.,Overgaard, M.T.,Olsen, O.H.,Gandhi, P.S.; Beating tissue factor at its own game: Design and properties of a soluble tissue factor-independent coagulation factor VIIa.; J.Biol.Chem., 295:517-528, 2020; PubMed: 31801825; DOI: 10.1074/jbc.RA119.009183

Experimental method

X-RAY DIFFRACTION (1.25 Å)